Marshall Edwards, Inc., to Present at the 26th Annual JPMorgan Healthcare Conference.

Jan 9, 2008

(Washington, DC January 9, 2008) Marshall Edwards Inc (NASDAQ:MSHL) will present at the 26th Annual JPMorgan Healthcare Conference in San Francisco on Thursday January 10, 2008 at 12:30 p.m.
Marshall Edwards, Inc. is developing a drug called phenoxodiol as a therapy for late-stage, chemoresistant ovarian cancer and for prostate and cervical cancers. It is a novel-acting drug that inhibits key pro-survival signaling pathways operating via sphingosine-1-phosphate and Akt. Inhibition of these pathways leads to prevention of phosphorylation of key anti-apoptotic proteins such as XIAP.  Loss of activity of these proteins induces cell death by apoptosis and restores the sensitivity of chemoresistant tumor cells to other chemotherapy drugs.  The putative molecular target for phenoxodiol is a cancer-specific protein, accounting for the highly selective nature of the drug.
This helps explain the findings that phenoxodiol has been shown not to adversely affect normal cells in animal and laboratory testing.
Phenoxodiol has received Fast Track status from the FDA to facilitate development as a therapy for recurrent ovarian and prostate cancers.  Phenoxodiol is an investigational drug and, as such, is not commercially available.  Under U.S. law, a new drug cannot be marketed until it has been investigated in clinical trials and approved by FDA as being safe and effective for the intended use.
Phase III Multinational Trial for Ovarian Cancer Patients Underway
Phenoxodiol in combination with carboplatin is currently being studied in a multinational Phase III clinical trial called the OVATURE (OVArian TUmor REsponse) Trial, following positive findings of previous trials conducted in Australia and at Yale-New Haven Hospital.  The OVATURE trial is taking place at up to 60 clinical sites in the United States, Europe, and Australia. Preliminary results from the trial are expected within 18 months. For more information on the trial, visit
About Marshall Edwards, Inc.
Marshall Edwards, Inc. has licensed rights from Novogen Limited (ASX: NRT  NASDAQ: NVGN) to bring three oncology drugs -- phenoxodiol, NV-196 and NV-143 -- to market globally. Marshall Edwards, Inc. is majority owned by Novogen, an Australian biotechnology company that is specializing in the development of therapeutics based on regulation of the sphingomyelin pathway.  Novogen, based in Sydney, Australia, is developing a range of therapeutics across the fields of oncology, cardiovascular disease and inflammatory diseases.  More information on phenoxodiol and on the Novogen group of companies can be found at and
Under U.S. law, a new drug cannot be marketed until it has been investigated in clinical trials and approved by the FDA as being safe and effective for the intended use. Statements included in this press release that are not historical in nature are "forward-looking statements" within the meaning of the "safe harbor" provisions of the Private Securities Litigation Reform Act of 1995. You should be aware that our actual results could differ materially from those contained in the forward-looking statements, which are based on management's current expectations and are subject to a number of risks and uncertainties, including, but not limited to, our failure to successfully commercialize our product candidates; costs and delays in the development and/or FDA approval, or the failure to obtain such approval, of our product candidates; uncertainties in clinical trial results; our inability to maintain or enter into, and the risks resulting from our dependence upon, collaboration or contractual arrangements necessary for the development, manufacture, commercialization, marketing, sales and distribution of any products; competitive factors; our inability to protect our patents or proprietary rights and obtain necessary rights to third party patents and intellectual property to operate our business; our inability to operate our business without infringing the patents and proprietary rights of others; general economic conditions; the failure of any products to gain market acceptance; our inability to obtain any additional required financing; technological changes; government regulation; changes in industry practice; and one-time events. We do not intend to update any of these factors or to publicly announce the results of any revisions to these forward-looking statements.