MARSHALL EDWARDS, INC.
 
(Name of Issuer)

Common Stock
 

(Title of Class of Securities)

572322402
 
(CUSIP Number)

12/31/2010
 
(Date of Event Which Requires Filing of this Statement)

[X]

Rule 13d-1(b)

[ ]

Rule 13d-1(c)

[ ]

Rule 13d-1(d)

CUSIP No. 572322402

1.

Names of Reporting Persons:
 
OppenheimerFunds, Inc.

IRS No. 13-252717

2.

Check the Appropriate Box if a Member of a Group (See Instructions): Joint filing

3.

SEC Use Only

4.

Citizenship or Place of Organization:
Colorado

Number of Shares Beneficially Owned by Each Reporting Person With:

5.

Sole Voting Power:

0

6.

Shared Voting Power:

761,281

7.

Sole Dispositive Power:

0

8.

Shared Dispositive Power:

761,281

9.

Aggregate Amount Beneficially Owned by Each Reporting Person:

761,281 (beneficial ownership disclaimed pursuant to Rule 13d-4 of the Exchange Act of 1934)

10.

Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)
[ ]

11.

Percent of Class Represented by Amount in Row (9):

10.33%

12.

Type of Reporting Person (See Instructions):

IA

CUSIP No. 572322402

1.

Names of Reporting Persons:

IRS Identification No: 13-3867060

Oppenheimer International Growth Fund

2.

Check the Appropriate Box if a Member of a Group (See Instructions): Joint filing

3.

SEC Use Only

4.

Citizenship or Place of Organization:

Massachusetts

Number of Shares Beneficially Owned by Each Reporting Person With:

5.

Sole Voting Power:

461,029

6.

Shared Voting Power:

0

7.

Sole Dispositive Power:

0

8.

Shared Dispositive Power:

461,029

9.

Aggregate Amount Beneficially Owned by Each Reporting Person:

461,029 (beneficial ownership disclaimed pursuant to Rule 13d-4 of the Exchange Act of 1934)

10.

Check if the Aggregate Amount in Row (9) Excludes Certain Shares (See Instructions)
[ ]

11.

Percent of Class Represented by Amount in Row (9):

6.25%

12.

Type of Reporting Person (See Instructions):

IV

Item:

1(a)

Name of Issuer:

MARSHALL EDWARDS INC.

1(b)

Address of Issuer's Principal Executive Offices:

11975 El Camino Real

Suite 101

San Diego, CA 92130

2(a)

Name of Person Filing:

(a) OppenheimerFunds, Inc.

(b) Oppenheimer International Growth Fund

2(b)

Address of Principal Business Office or, if none, Residence:

(a) Two World Financial Center

225 Liberty Street

New York, NY 10281

(b) 6803 S. Tucson Way
Centennial, CO 80112

2(c)

Citizenship:

(a) Colorado

(b) Massachusetts

2(d)

Title of Class of Securities:
Common Stock

2(e)

CUSIP Number:

572322402

3

OppenheimerFunds, Inc. is an investment adviser in accordance with Rule 13d-1(b)(1)(ii)(E). Oppenheimer International Growth Fund is an investment company registered under section 8 of the Investment Company Act of 1940.

4(a)

Amount beneficially owned:

(i) 761,281 (beneficial ownership disclaimed pursuant to Rule 13d-4 of the Exchange Act of 1934) (includes ownership reported in 4(b)(ii) below)

(ii461,029

4(b)

Percent of class:

(i) 10.33% (includes ownership reported in 4(b)(ii) below)

(ii) 6.25%

4(c)

(i)

(ii)

(iii)

(iv)

Number of shares as to which the person has:

Sole power to vote or to direct the vote:

(a) 0

(b) 0

Shared power to vote or to direct the vote:

(a) 761,281
(b) 461,029

Sole power to dispose or to direct the disposition of:

(a)      0

(b)     0

Shared power to dispose or to direct the disposition of:

(a) 761,281

(b) 461,029

5.

Ownership of Five Percent or Less of a Class: [ ]

6.

Ownership of More than Five Percent on Behalf of Another Person.:

N/A

7.

Identification and Classification of the Subsidiary Which Acquired the Security Being Reported on By the Parent Holding Company:
N/A

8.

Identification and Classification of Members of the Group:
N/A

9.

Notice of Dissolution of Group:
N/A

10.

Certification:
By signing below I certify that, to the best of my knowledge and belief, the securities referred to above were acquired and are held in the ordinary course of business and were not acquired and are not held for the purpose of or with the effect of changing or influencing the control of the issuer of the securities and were not acquired and are not held in connection with or as a participant in any transaction having that purpose or effect.