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AMENDMENT NO. 2

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Marshall Edwards, Inc.

Delaware		2834		51-0407811
(State or other jurisdiction of incorporation or organization)		(Primary Standard Industrial Classification Code Number)		(I.R.S. employer Identification Number)

Marshall Edwards, Inc.

The Corporation Trust Company

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With copies to:

David R. Seaton Secretary Marshall Edwards, Inc. 140 Wicks Road North Ryde NSW 2113 Australia (011) 61 2 8877 6196		Steven A. Navarro, Esq. Stephanie M. Gulkin, Esq. Morgan, Lewis & Bockius LLP 101 Park Avenue New York, New York 10178 (212) 309-6000		Robert B. Murphy, Esq. Raymond A. Miller, Esq. Pepper Hamilton LLP 600 Fourteenth Street, N.W. Washington, D.C. 20005-2004 (202) 220-1200

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     Approximate date of commencement of proposed sale to the public: As soon as practicable after this Registration Statement is declared effective.

      If any of the securities being registered on this Form are to be offered on a delayed or continuous basis pursuant to Rule 415 under the Securities Act of 1933, check the following box:     x

      If this Form is filed to register additional securities for an offering pursuant to Rule 462(b) under the Securities Act, please check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering.     o

      If this Form is a post-effective amendment filed pursuant to Rule 462(c) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering.     o

      If this Form is a post-effective amendment filed pursuant to Rule 462(d) under the Securities Act, check the following box and list the Securities Act registration statement number of the earlier effective registration statement for the same offering.     o

      If delivery of the prospectus is expected to be made pursuant to Rule 434, please check the following box.     o

      The Registrant hereby amends this Registration Statement on such date or dates as may be necessary to delay its effective date until the Registrant shall file a further amendment which specifically states that this Registration Statement shall thereafter become effective in accordance with Section 8(a) of the Securities Act or until the Registration Statement shall become effective on such date as the Commission, acting pursuant to said Section 8(a), may determine.

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The information contained in this prospectus is not complete and may be changed. We may not sell these securities until the registration statement filed with the Securities and Exchange Commission is effective. This prospectus is not an offer to sell these securities and we are not soliciting an offer to buy these securities in Australia or in any state or other jurisdiction where the offer or sale is not permitted.

SUBJECT TO COMPLETION, DATED NOVEMBER 26, 2003

PROSPECTUS

Marshall Edwards, Inc.

2,000,000 Common Stock Units

         This is our initial public offering in the United States. This prospectus covers the sale of up to an aggregate of 2,000,000 common stock units. Each common stock unit consists of:

•	one share of our common stock; and
•	one warrant to purchase a share of our common stock at an exercise price equal to 120% of the initial public offering price.

         The estimated initial public offering price for the common stock units is between $4.50 and $6.50 per unit.

         As part of this offering, we are offering up to an aggregate of 1,500,000 common stock units at the initial public offering price to U.S. holders of ordinary shares and American Depositary Receipts of Novogen Limited, our parent company, who owned their shares or receipts as of the close of business on October 20, 2003, and to our U.S. stockholders who owned their shares as of the close of business on October 20, 2003. See the section entitled “Plan of Distribution — Directed Share Subscription Program.”

         Upon completion of this offering, Novogen will own approximately 89.7% of our outstanding common stock.

         We have applied to list our common stock and warrants on the Nasdaq National Market under the symbols “MSHL and “MSHLW,” respectively. Our common stock is listed on the Alternative Investment Market of the London Stock Exchange plc under the symbol “MSH.” We will apply to list the shares of common stock being offered hereby on the Alternative Investment Market. The last reported sale price on the Alternative Investment Market on November 24, 2003 was £5.63 per share, or approximately $9.59 per share based on the noon buying rate for sterling of £1.00 = $1.7051 on that date.

         There will be no trading market for the common stock units. The shares of common stock and warrants comprising the units will separate immediately upon completion of this offering and prior to any trading of the common stock and warrants.

           Investment in the common stock units involves a high degree of risk. See “Risk Factors” beginning on page 6.

Underwritten Public Offering

Underwriting Discounts

Proceeds to

Public Offering Price

and Commissions

Marshall Edwards, Inc.

Per Common Stock Unit

$

$

$

Total

$

$

$

Directed Share Subscription Program

Proceeds to

Public Offering Price

Selling Fee

Marshall Edwards, Inc.

Per Common Stock Unit

$

$

$

Total

$

$

$

Aggregate Offering Proceeds

$

         We have granted the underwriter an option to purchase up to an additional 300,000 common stock units at the public offering price, solely to cover over-allotments.

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         Neither the Securities and Exchange Commission nor any state securities commission has approved or disapproved of these securities or passed upon the adequacy or accuracy of this prospectus. Any representation to the contrary is a criminal offense.

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Janney Montgomery Scott LLC

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The date of this prospectus is                     , 2003.

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PROSPECTUS SUMMARY
RISK FACTORS
SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS
USE OF PROCEEDS
DETERMINATION OF OFFERING PRICE
PRICE RANGE OF OUR COMMON STOCK
DIVIDEND POLICY
CAPITALIZATION
DILUTION
SELECTED HISTORICAL CONSOLIDATED FINANCIAL DATA
MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS
BUSINESS
MANAGEMENT
BENEFICIAL OWNERSHIP OF COMMON STOCK
CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS
DESCRIPTION OF OUR SECURITIES
SHARES ELIGIBLE FOR FUTURE SALE
PLAN OF DISTRIBUTION
LEGAL MATTERS
EXPERTS
AVAILABLE INFORMATION
ANNEX A
INDEX TO CONSOLIDATED FINANCIAL STATEMENTS
SIGNATURES
UNDERWRITING AGREEMENT
CONSENT OF ERNST & YOUNG LLP
FORM OF LETTER TO ELIGIBLE HOLDERS
FORM OF BROKERS LETTER
FORM OF SUBSCRIPTION AGREEMENT

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TABLE OF CONTENTS

		Page
PROSPECTUS SUMMARY			1
RISK FACTORS			6
SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS			17
USE OF PROCEEDS			18
DETERMINATION OF OFFERING PRICE			19
PRICE RANGE OF OUR COMMON STOCK			19
DIVIDEND POLICY			19
CAPITALIZATION			20
DILUTION			21
SELECTED HISTORICAL CONSOLIDATED FINANCIAL DATA			22
MANAGEMENT’S DISCUSSION AND ANALYSIS OF FINANCIAL CONDITION AND RESULTS OF OPERATIONS			23
BUSINESS			27
MANAGEMENT			42
BENEFICIAL OWNERSHIP OF COMMON STOCK			46
CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS			47
DESCRIPTION OF OUR SECURITIES			54
SHARES ELIGIBLE FOR FUTURE SALE			58
PLAN OF DISTRIBUTION			59
LEGAL MATTERS			62
EXPERTS			62
AVAILABLE INFORMATION			62
ANNEX A — GLOSSARY OF TERMS			A-1
INDEX TO CONSOLIDATED FINANCIAL STATEMENTS			F-1

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RISK FACTORS

      Investors should carefully consider the following risks, as well as the other information contained in this prospectus before investing in our common stock units. If any of the following risks actually materializes, our business could be harmed, the price of our shares of common stock could decline and investors might lose all or part of their investment.

Risks Related to Our Business

	We have a limited operating history, and we are likely to incur operating losses for the foreseeable future.

      Investors should consider our prospects in light of the risks and difficulties frequently encountered by early stage and developmental companies. Although we were incorporated in December 2000, we have only been in operation since May 2002. In May 2002, we raised $10.1 million in a private placement of shares of common stock and warrants. We have incurred net losses since our inception, including net losses of $3,033,000 and $123,000 for the years ended June 30, 2003 and 2002, respectively. For the quarter ended September 30, 2003, we incurred a net loss of $1,114,000. We anticipate that we will incur operating losses and negative cash flow for the foreseeable future. We have not yet commercialized any products and cannot be sure that we will ever be able to do so, or that we may ever become profitable. We expect to expand our clinical trials significantly, which will result in increasing losses, and may continue to incur substantial losses even if we begin to generate revenues from the distribution and sale of phenoxodiol.

	If we are unable to successfully develop and commercialize phenoxodiol or license other viable drug candidates, our ability to sustain future operations will be significantly diminished.

      We are currently developing only one drug, phenoxodiol. We cannot guarantee that phenoxodiol will be successful. Although we have rights to potentially develop other related compounds discovered and developed by Novogen under the terms of our amended and restated license option deed with Novogen, our rights under our amended and restated license agreement with Novogen are limited to the commercialization of phenoxodiol as an anti-cancer agent and these rights specifically exclude phenoxodiol in a topical application. If we are unable to successfully develop and commercialize phenoxodiol or other viable drug candidates, we may be required to cease or reduce our operations.

	If we do not receive regulatory approval for phenoxodiol or such approval is withdrawn, we will not be able to commercialize phenoxodiol.

      We need regulatory approval in order to commercialize phenoxodiol. We may never receive regulatory approval or if we do receive regulatory approval, it will be limited to those disease states and conditions for which phenoxodiol has proven to be safe and effective. Phenoxodiol is currently in Phase II clinical trials in intravenous dosage form to treat late stage ovarian cancer. An IND became effective for phenoxodiol in the United States for the oral dosage form in June 2003. The oral dosage form is also in clinical trials in Australia to treat prostate cancer and SCC. Product approval, if granted, can be withdrawn for failure to comply with regulatory requirements or upon the occurrence of adverse events following commercial introduction. In addition, our ability to market phenoxodiol in overseas countries is contingent upon receiving the required regulatory approvals in those countries. If we cannot commercialize phenoxodiol, we may be required to cease or reduce our operations. While we have not encountered any material delays, difficulties or adverse events in the regulatory process to date, we cannot assure you that such delays or adverse events will not be encountered in the future.

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	Our ability to achieve profitability is dependent on a number of factors, many of which are beyond our control.

      Our ability to achieve profitability is dependent on a number of factors including:

	•	Completing our clinical trial program and receiving regulatory approval. Clinical testing is a prerequisite to the receipt of the regulatory approval necessary to commercialize phenoxodiol. We cannot control the outcome of our testing program or whether we receive regulatory approval. We will not be able to generate sales revenues until we receive regulatory approval;
	•	Establishing strategic partnerships to market and sell phenoxodiol. Our negotiating position with potential strategic partners will be affected by the success of our clinical program. If we are unable to attract partners and negotiate favorable terms, we may have difficulty generating revenues from our commercialization of phenoxodiol;
	•	Maintaining a low cost operation and scalable supply of phenoxodiol capable of meeting the demands of the commercial market. We have contracted with Novogen for the supply of phenoxodiol and Novogen has fully complied with the terms of our amended and restated manufacturing license and supply agreement. Under the terms of the manufacturing license and supply agreement, the supply of phenoxodiol is charged to us on a cost-plus basis. We do not have direct control over the manufacturing costs of phenoxodiol. We cannot control Novogen’s ability to expand its production capabilities to produce the large quantities that may be required by the commercial market. If our costs for the supply of phenoxodiol rise or if Novogen fails to supply sufficient quantities of phenoxodiol, our profitability could be adversely affected; and
	•	Our ability to license from Novogen rights to commercialize new cancer compounds. We may license from Novogen the rights to other cancer compounds under the terms of the license option deed. If development of phenoxodiol is unsuccessful or if we choose to expand to the development of additional compounds, our success may depend on controlling the costs of developing such new compounds and negotiating a favorable license agreement with Novogen. The availability of new compounds to commercialize and the cost to develop these compounds is outside of our direct control.

	We have no direct control over the costs of manufacturing phenoxodiol and increases in these costs would increase the costs of conducting clinical trials and could adversely affect future profitability if these costs increase significantly.

      We do not intend to manufacture phenoxodiol ourselves and we will be relying on third parties for our supplies of phenoxodiol both for clinical trials and for commercial quantities in the future. We have contracted with Novogen to manufacture and supply us with our requirements of phenoxodiol. The cost of manufacturing phenoxodiol is charged to us on a cost-plus markup basis. We have no direct control over the costs of manufacturing phenoxodiol. If the costs of manufacturing phenoxodiol increase or if the cost of the materials used to make phenoxodiol increases, these costs will be passed on to us by Novogen making the cost of conducting clinical trials more expensive. If, in the future, a third party other than Novogen manufactures and supplies us with phenoxodiol, we will not have direct control over those manufacturing costs. Once we are able to commercialize phenoxodiol, increases in manufacturing costs could adversely affect our future profitability if we are unable to pass all of the increased costs along to our customers.

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	Final approval by regulatory authorities of phenoxodiol for commercial use may be delayed, limited or prevented, any of which would adversely affect our ability to generate operating revenues.

      Any of the following factors may serve to delay, limit or prevent the final approval by regulatory authorities of phenoxodiol for commercial use:

	•	phenoxodiol is in the early stages of clinical development and we will need to conduct significant clinical testing to prove safety and efficacy before applications for marketing can be filed with the FDA, or with the regulatory authorities of other countries, to approve phenoxodiol for final use;
	•	data obtained from pre-clinical and clinical tests can be interpreted in different ways, which could delay, limit or prevent regulatory approval;
	•	it may take us many years to complete the testing of phenoxodiol or any other drug candidates, and failure can occur at any stage of this process;
	•	negative or inconclusive results or adverse medical events during a clinical trial could cause us to delay or terminate our development efforts;
	•	there is relatively limited scientific understanding of the means by which cells respond to chemical signals that reach them through the bloodstream, which we refer to as multiple signal transduction regulation or MSTR, the class of drug compounds to which phenoxodiol belongs; and
	•	the commercialization of phenoxodiol may be delayed if the FDA or another regulatory authority requires us to expand the size and/or scope of the clinical trials.

      While we have not encountered any material delays or adverse events from the factors described above to date, we cannot assure you that such delays or adverse events will not be encountered in the future.

	We may not be able to establish the strategic partnerships necessary to market and distribute phenoxodiol.

      A key part of our business plan is to establish relationships with strategic partners. We must successfully contract with third parties to package, market and distribute phenoxodiol. We have not yet established any strategic partnerships. Potential partners may not wish to enter into agreements with us due to Novogen’s current equity position as our majority stockholder or our contractual relationships with Novogen. Similarly, potential partners may be discouraged by our limited operating history. Additionally, our relative attractiveness to potential partners and consequently, our ability to negotiate acceptable terms in any partnership agreement will be affected by the results of our clinical program. For example, if phenoxodiol is shown to have high efficacy against a broad range of cancers, we may generate greater interest from potential partners than if phenoxodiol was demonstrated to be less effective or applicable to a narrower range of cancers. There is no assurance that we will be able to negotiate commercially acceptable licensing or other agreements for the future exploitation of phenoxodiol, including the continued clinical development, manufacture or marketing of phenoxodiol. If we are unable to successfully contract for these services, or if arrangements for these services are terminated, we may have to delay our commercialization program for phenoxodiol, which will adversely affect our ability to generate operating revenues.

	We may not be able to secure and maintain suitable research institutions to conduct our clinical trials.

      We rely on suitable research institutions, of which there are many, to conduct our clinical trials. While we have not previously experienced problems with third parties upon whom we rely for research or clinical trials, our reliance upon research institutions, including hospitals and cancer clinics, provides us with less control over the timing and cost of clinical trials and the ability to recruit patients than if we had conducted the trials on our own. Further, there is a greater likelihood that disputes may arise with these research institutions over the ownership of intellectual property discovered during the clinical trials. If we are unable to retain suitable research institutions on acceptable terms, or if any resulting agreement is terminated and we are unable to quickly replace the applicable research institution with another qualified

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	Any failure in our clinical trials could impair the commercial prospects for phenoxodiol.

      Clinical trials have a high risk of failure. A number of companies in the pharmaceutical industry, including biotechnology companies, have suffered significant setbacks in advanced clinical trials, even after achieving promising results in earlier trials. While we have not had any material delays in our clinical testing program, if we experience delays in the testing or approval process or need to perform more or larger clinical trials than originally planned, our commercial prospects for phenoxodiol or any other drug candidates may be impaired and we may be required to cease or reduce our operations.

	We will need to raise additional funds to complete Phase III clinical trials and commercialize phenoxodiol, and the actual amount of funds we will need will be determined by a number of factors, some of which are beyond our control.

      Based on our current plans, we believe that the net proceeds of this offering will provide sufficient funds to:

      • complete the current Phase Ib/IIa and Phase II clinical trials;

	•	commence Phase II clinical trials of phenoxodiol as a monotherapy in earlier stage cancers; and
	•	commence Phase II clinical trials of phenoxodiol in combinational therapy with other anti-cancer drugs for late stage chemo-resistant tumors.

      We will require additional funds, however, to further the evaluation of phenoxodiol beyond these current objectives, including the completion of any Phase III clinical trials for phenoxodiol, and to pursue the commercialization of phenoxodiol.

      The actual amount of funds that we will need will be determined by many factors, some of which are beyond our control. As a result, we may need additional funds sooner than we currently anticipate. These factors include:

	•	the progress of research activities;
	•	the number and scope of research programs;
	•	the progress of pre-clinical and clinical development activities;
	•	the progress of the development efforts of Novogen or any other parties with whom we enter into research and development agreements;
	•	our ability to establish and maintain current and new research and development and licensing arrangements;
	•	our ability to achieve milestones under licensing arrangements;
	•	the costs involved in enforcing or defending patent claims and other intellectual property rights; and
	•	the costs and timing of regulatory approvals.

      If our capital resources are insufficient to meet future capital requirements, we will have to raise additional funds. If we are unable to obtain additional funds on favorable terms we may be required to cease or reduce our operations. Also, if we raise more funds by selling additional shares of our common stock or securities convertible into or exercisable for shares of our common stock, your ownership interests may be diluted.

	Our commercial opportunity will be reduced or eliminated if competitors develop and market products that are more effective, have fewer side effects or are less expensive than phenoxodiol.

      The development of phenoxodiol and other drug candidates is highly competitive. A number of other companies have products or drug candidates in various stages of pre-clinical or clinical development to treat prostate cancer, ovarian cancer, SCC and other cancers that are the current focus of phenoxodiol.

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      Iressa, a signal transduction inhibitor manufactured by AstraZeneca, is a potential competing treatment that has recently been granted FDA approval for use in the treatment of advanced stage non-small cell lung cancer in patients who have already received specific chemotherapy. Other potential competition might arise from the development of drugs with a related chemical heritage to phenoxodiol. Genistein and flavopiridol^TM are two chemicals with an underlying flavonoid chemical structure with known anti-cancer activity which are undergoing clinical development as anti-cancer agents. Our understanding is that genistein is in Phase II clinical studies, while we believe flavopiridol^TM, under development by Aventis, is in Phase III clinical testing.

      Our competitors include pharmaceutical companies and biotechnology companies, as well as universities and public and private research institutions. In addition, companies active in different but related fields represent substantial competition for us. Many of our competitors, including Aventis and AstraZeneca, have significantly greater capital resources, larger research and development staffs and facilities and greater experience in drug development, regulation, manufacturing and marketing than us. These organizations also compete with Novogen, our services provider, to recruit qualified personnel, and with us to attract partners for joint ventures and to license technologies that are competitive with ours. As a result, our competitors may be able to more easily develop technologies and products that would render our technologies or our drug candidates obsolete or non-competitive.

	We depend on a number of key personnel whose services are provided by Novogen under our amended and restated services agreement. If we are not able to procure these services in the future, the strategic direction of the clinical development program would be disrupted, causing a delay in phenoxodiol’s commercialization.

      We currently rely on Dr. Graham Kelly, our Chairman and phenoxodiol Program Director, Professor Alan Husband, Novogen Research Director, and Mr. Chris Naughton, our President and CEO, to provide the strategic direction for the clinical development of phenoxodiol. If we are unable to secure the ongoing services of these key personnel, the commercialization program for phenoxodiol will be disrupted and will cause delays in obtaining marketing approval. Novogen has entered into employment agreements and maintains key man life insurance policies for each of these persons.

	Our right to develop and exploit phenoxodiol is subject to the terms and conditions of agreements we have entered into with Novogen and under these agreements our rights may be terminated under certain circumstances, some of which may be beyond our control.

      We have licensed the intellectual property in the phenoxodiol technology from Novogen. All forms of administering phenoxodiol for the treatment of cancer are licensed to us, excluding topical applications. If we fail to meet our obligations under our license agreement, the manufacturing license and supply agreement or the services agreement with Novogen, any or all of these agreements may be terminated by Novogen and we could lose our rights to develop phenoxodiol. See “Certain Relationships and Related Transactions” for a description of our principal obligations under our agreements with Novogen. As of the date of this prospectus, we have no reason to believe that we will be unable to satisfy our obligations under these agreements. In addition, each of these agreements may be terminated immediately by Novogen in the event that we undergo a change of control without the consent of Novogen. A “change of control” means a change in control of more than half the voting rights attaching to the shares of our subsidiary, a change in control of more than half of the issued shares of our subsidiary (not counting any share which carries no right to participate beyond a specified amount in the distribution of either profit or capital) or a change in control of the composition of the board of directors of our subsidiary. Each of these agreements may also be terminated if we become the subject of certain bankruptcy proceedings or cease for any reason to be able to lawfully carry out all the transactions required by each respective agreement.

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	Our license rights are fundamental to our business and therefore a loss of these rights will likely cause us to cease operations.

      The rights granted to us under the license agreement, the manufacturing license and supply agreement and the license option deed with Novogen are fundamental to our business.

      The license agreement grants us the right to make, have made, market, distribute, sell, hire or otherwise dispose of phenoxodiol products in the field of prevention, treatment or cure of cancer in humans by pharmaceuticals delivered in all forms except topical applications. Our business purpose is to develop and commercialize cancer drugs including phenoxodiol, which we would be unable to pursue without the rights granted to us under the license agreement.

      Under the manufacturing license and supply agreement, we have granted to Novogen an exclusive sub-license to manufacture and supply phenoxodiol to us in its primary manufactured form and Novogen has agreed to manufacture for us our required quantities of phenoxodiol. This agreement enables us to protect the licensed intellectual property rights used in the manufacturing process while securing the services of a manufacturing partner, in Novogen, which through its equity position in us, shares a common interest in the production of phenoxodiol.

      The license option deed grants us an exclusive first right to accept and exclusive last right to match any proposed dealing by Novogen with its intellectual property rights with a third party relating to certain compounds (other than phenoxodiol) developed by Novogen and its affiliates which have applications in the field of prevention, treatment or cure of cancer in humans. The license option deed is important to our business because it allows us to maintain control over the sale by Novogen of complementary as well as potentially competitive intellectual property rights to third party competitors.

      Any loss of the rights under any of these agreements will likely cause us to cease operations.

	The success of phenoxodiol is largely dependent on Novogen’s ability to obtain and maintain patent protection and preserve trade secrets, which cannot be guaranteed.

      Patent protection and trade secret protection are important to our business and our future will depend, in part, on our ability and the ability of Novogen to maintain trade secret protection, obtain patents and operate without infringing the proprietary rights of others both in the United States and abroad. Litigation or other legal proceedings may be necessary to defend against claims of infringement, to enforce our patents, or to protect our trade secrets or the trade secrets of Novogen. Such litigation could result in substantial costs and diversion of our management’s attention. Novogen has not been involved in any opposition, re-examination, trade secret dispute, infringement litigation or any other litigation or legal proceedings pertaining to the licensed patent rights.

      The patent positions of pharmaceutical and biotechnology companies can be highly uncertain and involve complex legal and factual questions. Novogen has applied for patents in a number of countries with respect to the use of phenoxodiol for the treatment, prevention or cure of cancer. We have licensed both issued patents and pending patent applications from Novogen. Novogen has issued patents in the United States, Australia and Singapore covering the use of phenoxodiol to prevent or treat skin cancer from ultraviolet damage. Novogen also has patents issued in Australia, Hong Kong, New Zealand and the United Kingdom related to phenoxodiol for the treatment of a variety of cancers and has recently received a notice of allowance in the United States that is also related to phenoxodiol for the treatment of a variety of cancers.

      Novogen’s applications may not proceed to grant or may be amended to reduce the scope of protection of any patent granted. The applications and patents may also be opposed or challenged by third parties. Our commercial success will depend, in part, on the ability of Novogen and our ability to obtain and maintain effective patent protection for the technologies underlying phenoxodiol and other compounds, and to successfully defend patent rights in those technologies against third-party challenges. As patent applications in the United States are maintained in secrecy until published or issued and as publication of discoveries in the scientific or patent literature often lag behind the actual discoveries, we cannot be

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	Claims by other companies that we infringe their proprietary technology may result in liability for damages or stop our development and commercialization efforts.

      The pharmaceutical industry is highly competitive and patents have been applied for by, and issued to, other parties relating to products competitive with phenoxodiol. Therefore, phenoxodiol and any other drug candidates may give rise to claims that they infringe the patents or proprietary rights of other parties existing now and in the future. Furthermore, to the extent that we or Novogen or our respective consultants or research collaborators use intellectual property owned by others in work performed for us or Novogen, disputes may also arise as to the rights in such intellectual property or in resulting know-how and inventions. An adverse claim could subject us to significant liabilities to such other parties and/or require disputed rights to be licensed from such other parties.

      We cannot be sure that any license required under any such patents or proprietary rights would be made available on terms acceptable to us, if at all. If we do not obtain such licenses, we may encounter delays in product market introductions, or may find that the development, manufacture or sale of products requiring such licenses may be precluded. We have not conducted any searches or made any independent investigations of the existence of any patents or proprietary rights of other parties.

	We may be subject to substantial costs stemming from our defense against third-party intellectual property infringement claims.

      Third parties may assert that we or Novogen are using their proprietary information without authorization. Third parties may also have or obtain patents and may claim that technologies licensed to or used by us infringe their patents. If we are required to defend patent infringement actions brought by third parties, or if we sue to protect our own patent rights, we may be required to pay substantial litigation costs and managerial attention may be diverted from business operations even if the outcome is not adverse to us. In addition, any legal action that seeks damages or an injunction to stop us from carrying on our commercial activities relating to the affected technologies could subject us to monetary liability and require us or Novogen or any third party licensors to obtain a license to continue to use the affected technologies. We cannot predict whether we or Novogen would prevail in any of these types of actions or that any required license would be made available on commercially acceptable terms or at all.

	In the event that Novogen does not comply with its obligations under a grant from the Australian government under which phenoxodiol was, in part, developed, our rights to use the intellectual property relating to phenoxodiol and developed by Novogen may revert back to the Australian government.

      Novogen developed phenoxodiol, in part, using funds from the Australian government under what is known as the START Program. Under the START Program, Novogen must meet certain project development and commercialization obligations. Novogen has met the project development obligations and has received final payment thereon. Novogen believes it is currently in compliance with its commercialization schedule. Although Novogen believes that it has complied with its obligations under the START Program, if the Australian government disagrees, or if Novogen undergoes a change of control without the prior consent of the Australian Government, the Australian government has a right to demand that intellectual property created during the course of the project funded by the grant be vested back in the Australian government or demand repayment of the funds paid to Novogen under the program. The Australian government may then license the intellectual property rights related to phenoxodiol to other

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	The enforcement of civil liabilities against our officers and directors may be difficult.

      All of our officers and directors are residents of jurisdictions outside the United States. As a result, it may be difficult for you to effect service of process within the United States upon our officers and directors or to enforce judgments obtained against our officers and directors or us in United States courts.

	Our revenue is affected by fluctuations in currency exchange rates.

      Much of our expenditures and potential revenue will be spent or derived outside of the United States. As a result, fluctuations between the United States dollar and the currencies of the countries in which we operate may increase our costs or reduce our potential revenue. At present, we do not engage in hedging transactions to protect against uncertainty in future exchange rates between particular foreign currencies and the U.S. dollar.

	We are authorized to issue a class of blank check preferred stock, which could adversely affect the holders of our common stock.

      Our certificate of incorporation allows us to issue a class of blank check preferred stock with rights potentially senior to those of our common stock without any further vote or action by the holders of our common stock. The issuance of preferred stock could decrease the amount of earnings and assets available for distribution to the holders of our common stock or could adversely affect the rights and powers, including voting rights, of such holders. In certain circumstances, such issuance could have the effect of decreasing the market price of our shares, or making a change in control of us more difficult.

Risks Related to Our Relationship with Novogen

	As our majority stockholder, Novogen will have the ability to determine the outcome of all matters submitted to our stockholders for approval and Novogen’s interests may conflict with our’s or our other stockholders’ interests.

      Upon completion of this offering, Novogen will beneficially own approximately 90% of our outstanding shares of common stock assuming no additional warrants are exercised. As a result, Novogen will have the ability to effectively determine the outcome of all matters submitted to our stockholders for approval, including the election and removal of directors and any merger, consolidation or sale of all or substantially all of our assets.

      Novogen will have the ability to effectively control our management and affairs. Novogen’s interests may not always be the same as that of our other stockholders. In addition, this concentration of ownership may harm the market price of our shares by:

	•	delaying, deferring or preventing a change in control;
	•	impeding a merger, consolidation, takeover or other business combination involving us;
	•	discouraging a potential acquirer from making a tender offer or otherwise attempting to obtain control of us; or
	•	selling us to a third party.

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	A majority of our directors are officers and/or directors of Novogen which may create a conflict of interest.

      Four of our six existing board members, including our Chairman, currently serve as board members of Novogen. Our President and Chief Executive Officer, Christopher Naughton, is the Managing Director of Novogen. Our Chief Financial Officer and Secretary, David Ross Seaton, is the Chief Financial Officer of Novogen. Simultaneous service as a Novogen director or officer can create, or appear to create, a conflict of interest, when such directors or officers are presented with decisions that could have different implications for us and for Novogen.

	Novogen can compete with us.

      We have no contract, arrangement or understanding with Novogen to preclude it from developing a product which may be competitive with phenoxodiol or to use phenoxodiol for any uses other than anti-cancer applications. Novogen has reserved the intellectual property rights and know-how rights relating to topical applications of phenoxodiol even in the field of cancer. There can be no assurance that Novogen or its subsidiaries will not pursue alternative technologies or product candidates either on its own or in collaboration with others, as a means of developing treatments for the conditions targeted by phenoxodiol or any other product candidate which we seek to exploit.

	We are dependent on Novogen for our personnel.

      We have no employees. We rely on Novogen to provide or procure the provision of staff and other financial and administrative services under our services agreement with Novogen. Novogen has fully complied with the terms of our services agreement. To successfully develop phenoxodiol, we will require ongoing access to the personnel who have, to date, been responsible for the development of phenoxodiol. The services agreement does not specify a minimum amount of time that Novogen employees must devote to our operations. If we are unable to secure or if we lose the services of these personnel, the ability to develop phenoxodiol could be materially impaired. Moreover, if our business experiences substantial and rapid growth, we may not be able to secure the services and resources we require from Novogen or from other persons to support that growth.

	We are largely dependent on Novogen for our supply of phenoxodiol and, should Novogen be unable to supply commercial quantities of phenoxodiol, it may be difficult to secure an alternative source.

      We currently intend that phenoxodiol will be supplied to us in its primary manufactured form by Novogen under the manufacturing license and supply agreement. As the manufacturing process for phenoxodiol has not been tested in the quantities needed for commercial sales, we may be unable to receive the necessary quantities in a timely manner. In addition, in order for Novogen to supply commercial quantities of phenoxodiol in due course, it will need to build a new manufacturing plant. To build a new manufacturing plant, Novogen will need to scale up its current pilot plant. If the plant proves difficult to scale up or requires significant redesign, our ability to commercialize phenoxodiol could be delayed. Any larger manufacturing plant built by Novogen will also have to comply with the FDA’s current Good Manufacturing Practices, or cGMPs. Also, significant additional capital will be required to build the plant. Such capital may not be available to Novogen.

      If Novogen materially and persistently fails to supply us with the quantities of phenoxodiol that we require, the manufacturing license and supply agreement permits us, and we would consider, contracting with third party manufacturers for the production of phenoxodiol. Any third party manufacturer would have to satisfy cGMPs and would have to meet our quality assurance standards. In addition, it may be difficult to negotiate acceptable terms with any third party manufacturer.

Risks Related to this Offering

	An active trading market for shares of our common stock or our warrants may not develop following their admission to the Nasdaq National Market.

      Prior to this offering, there has not been a public trading market for our common stock or our warrants in the United States. An active, liquid trading market for our common stock or our warrants may not develop or be maintained following this offering. As a result, you may not be able to sell your shares

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	The trading price of the shares of our common stock and warrants could be highly volatile, your investment could decline in value, and we may incur significant costs from class action litigation.

      The trading price of our common stock and warrants could be highly volatile in response to various factors, many of which are beyond our control, including:

	•	developments concerning phenoxodiol;
	•	announcements of technological innovations by us or our competitors;
	•	new products introduced or announced by us or our competitors;
	•	changes in financial estimates by securities analysts;
	•	actual or anticipated variations in operating results;
	•	expiration or termination of licenses, research contracts or other collaboration agreements;
	•	conditions or trends in the regulatory climate and the biotechnology, pharmaceutical and genomics industries;
	•	changes in the market valuations of similar companies;
	•	the liquidity of any market for our securities;
	•	trading prices of our common stock on the Alternative Investment Market of the London Stock Exchange; and
	•	additional sales by us or Novogen of shares of our common stock.

      In addition, equity markets in general, and the market for biotechnology and life sciences companies in particular, have experienced substantial price and volume fluctuations that have often been unrelated or disproportionate to the operating performance of companies traded in those markets. In addition, changes in economic conditions in the United States, Europe or globally, could impact upon our ability to grow profitably. Adverse economic changes are outside our control and may result in material adverse impacts on our business or our results of operations. These broad market and industry factors may materially affect the market price of our shares of common stock and warrants, regardless of our development and operating performance. In the past, following periods of volatility in the market price of a company’s securities, securities class-action litigation has often been instituted against that company. Such litigation, if instituted against us could cause us to incur substantial costs and divert management’s attention and resources.

	If you are a subscriber in the directed share subscription program, you may be obligated to purchase common stock units even if you are the only subscriber or even if the underwriter does not purchase any units in the underwritten offering.

      The closing of the underwritten offering and the directed share subscription program are not conditioned upon one another. Although we can terminate the directed share subscription program at any time prior to the closing if you subscribe to purchase common stock units under the directed share subscription program, you may be obligated to purchase the units even if you are the only subscriber or even if the underwriter does not purchase any units in the underwritten offering.

     Future sales of our common stock may depress our stock price.

      The market price of our common stock could decline as a result of sales of substantial amounts of our common stock in the public market after this offering, or the perception that these sales could occur. In addition, these factors could make it more difficult for us to raise funds through future equity offerings. There will be 55,191,000 shares of our common stock outstanding immediately after this offering not including the 2,000,000 shares of common stock underlying the warrants offered hereby and 1,355,000

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      All of the shares of our common stock sold in this offering will be freely transferable by persons other than our affiliates without restriction or further registration under the Securities Act. The remaining shares of common stock outstanding will be “restricted securities” as defined in Rule 144 of the Securities Act. These shares may be sold in the future without registration under the Securities Act to the extent permitted by Rule 144 or other exemptions under the Securities Act. See “Shares Eligible for Future Sale.”

	You will experience immediate and substantial dilution as a result of this offering and may experience additional dilution in the future.

      If you purchase common stock units in this offering, you will in effect pay more for your shares of common stock than the amounts paid by existing stockholders for their shares. As a result, you will incur immediate and substantial dilution of $5.24 per share at an assumed initial offering price of $5.50 per unit, the midpoint of the range set forth on the cover page of this prospectus, representing the difference between our pro forma net tangible book value per share at September 30, 2003 after giving effect to this offering and the initial public offering price. In addition, purchasers of our common stock units in this offering will have contributed approximately 50% of the aggregate price paid by all purchasers of our common stock, but will own only approximately 4.9% of the shares outstanding after this offering based on the number of shares of our common stock outstanding as of September 30, 2003. Further, if the holders of the currently outstanding warrants exercise those warrants at prices below the initial public offering price, you will experience further dilution. We may also acquire other companies or technologies or finance strategic alliances by issuing equity, which may result in additional dilution to our stockholders.

	You will not be able to exercise the warrants offered hereby if we do not maintain the effectiveness of the registration statement and a current prospectus.

      If we do not maintain an effective registration statement and a current prospectus or comply with applicable state securities laws, you may not be able to exercise the warrants offered hereby. In order for you to be able to exercise the warrants, the shares underlying the warrants must be covered by an effective registration statement and a current prospectus and be qualified for sale or exempt from qualification under the applicable securities laws of the state in which you reside. Although we cannot assure you that we will actually be able to do so, we will use our best efforts to:

	•	maintain an effective registration statement and a current prospectus covering the shares of our common stock underlying the warrants at all times when the market price of the common stock exceeds the exercise price of the warrants until the expiration of the warrants, and
	•	maintain the registration of such shares under the securities laws of the states, if any, in which we initially qualify the common stock units for sale in this offering.

	There can be no assurance that the trading price of our common stock will exceed the exercise price of the warrants being sold in this offering.

      The warrants will entitle the holders to purchase one share of our common stock at an exercise price equal to 120% of the initial public offering price anytime after issuance until the warrants expire on the third anniversary of their issuance. There can be no assurance that the trading prices of our common stock will exceed the exercise price of the warrants. As a result, your warrants could expire and have no value.

	We will have broad discretion over the use of the net proceeds to us from this offering.

      We will have broad discretion to use the net proceeds to us from this offering, and you will be relying on the judgment of our board of directors and management regarding the application of these proceeds. Although we expect to use a substantial portion of the net proceeds from this offering for general corporate purposes, including potential payments to Novogen under the terms of the license agreement, potential licensing of other cancer compounds developed by Novogen under the license option deed and potential expansion of the clinical trial program for phenoxodiol to include other forms of cancer, we have not allocated these net proceeds for specific purposes.

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SPECIAL NOTE REGARDING FORWARD-LOOKING STATEMENTS

      This prospectus includes forward-looking statements. All statements other than statements of historical facts contained in this prospectus, including statements regarding our future financial position, business strategy and plans and objectives of management for future operations, are forward-looking statements. The words “believe,” “may,” “will,” “estimate,” “continue,” “anticipate,” “intend,” “should,” “plan,” “expect” and similar expressions, as they relate to us, are intended to identify forward-looking statements. We have based these forward-looking statements largely on our current expectations and projections about future events and financial trends that we believe may affect our financial condition, results of operations, business strategy and financial needs. These forward-looking statements are subject to a number of risks, uncertainties and assumptions described in “Risk Factors” and elsewhere in this prospectus, including, among other things:

	•	receipt of regulatory approvals;
	•	successful completion of clinical trials;
	•	continued cooperation and support of Novogen, our parent;
	•	future expenses and financing requirements; and
	•	competition and competitive factors.

      These risks are not exhaustive. Other sections of this prospectus may include additional factors which could adversely impact our business and financial performance. Moreover, we operate in a very competitive and rapidly changing environment. New risk factors emerge from time to time and it is not possible for us to predict all risk factors, nor can we assess the impact of all factors on our business or the extent to which any factor, or combination of factors, may cause actual results to differ materially from those contained in any forward-looking statements.

      You should not rely upon forward-looking statements as predictions of future events. We cannot assure you that the events and circumstances reflected in the forward-looking statements will be achieved or occur. Although we believe that the expectations reflected in the forward-looking statements are reasonable, we cannot guarantee future results, levels of activity, performance or achievements.

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USE OF PROCEEDS

      We expect to receive approximately $9,065,000 million in net proceeds from this offering ($10,616,000 if the underwriter exercises its over-allotment option in full), assuming an initial public offering price of $5.50 per common stock unit, the midpoint of the range set forth on the cover page of this prospectus, after deducting underwriting discounts and commissions, and estimated offering expenses. For purposes of determining the expected net proceeds from this offering, we have assumed that all 2,000,000 common stock units are sold in the underwritten offering. The net proceeds of this offering will be higher to the extent units are sold under the directed share subscription program since the selling fee payable to the dealer manager under the directed share subscription program is lower than the underwriting discounts and commissions.

•	We intend to use approximately $1.1 million to commence Phase II clinical trials of phenoxodiol as a monotherapy in early-stage prostate cancer, SCC of the cervix, vagina and vulva, and possibly other tumors such as breast cancer where diagnosis of early stage disease is available;
•	We intend to use approximately $4.2 million to commence Phase II clinical trials of phenoxodiol in combinational therapy with standard anti-cancer drugs for late-stage, chemo-resistant ovarian cancer, and possibly other tumors such as renal cancer; and
•	We intend to use the remainder for general corporate purposes, including:

•	potential payments to Novogen under the terms of the license agreement,
•	potential licensing of other cancer compounds developed by Novogen under the license option deed and
•	potential expansion of the clinical trial program for phenoxodiol to include other forms of cancer.

	See “Certain Relationships and Related Transactions — The Amended and Restated License Agreement — Fees, Charges and Costs” for a description of our potential payments to Novogen under the license agreement.

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DETERMINATION OF OFFERING PRICE

      Prior to this offering, there has been no trading market for our common stock in the United States. The shares of common stock and warrants comprising the units being offered hereby will separate immediately upon completion of this offering and prior to any trading of the common stock and warrants. There will be no trading market for the common stock units. Our common stock is listed on the Alternative Investment Market of the London Stock Exchange. The initial public offering price will be determined by negotiation between us and the underwriter based on a number of factors, including the historic trading prices of our common stock on the AIM, that may not be indicative of prices that will prevail in the trading market for our common stock in the United States. Other factors that will be considered in our negotiations with the underwriter include the history and the prospects for the industry in which we compete, an assessment of our management, our prospects, the general condition of the securities markets at the time of this offering, the recent market prices of, and the demand for, publicly traded securities of generally comparable companies and certain other factors as are deemed relevant.

      Our common stock has traded on the AIM since May 2002 under the symbol “MSH.” The following table sets forth, for the periods indicated, the high and low closing sale prices for our common stock as reported by the London Stock Exchange. The trading price for our shares of common stock on the AIM are quoted in sterling (£), the lawful currency of the United Kingdom. The following table also shows the high and low closing sales price of our common stock expressed in dollars based upon the average noon buying rate for sterling for the periods indicated.

Quarter Ended		High				Low				High				Low
June 30, 2002			£2.87				£2.35			$	4.11			$	3.36
September 30, 2002			£2.46				£2.35			$	3.81			$	3.64
December 31, 2002			£2.49				£2.46			$	3.84			$	3.79
March 31, 2003			£2.47				£2.28			$	3.96			$	3.65
June 30, 2003			£3.50				£2.35			$	5.66			$	3.80
September 30, 2003			£3.90				£3.33			$	6.28			$	5.36

      The following table sets forth, for the period indicated, the high, low, average and period-end noon buying rate for sterling, expressed in dollars per sterling in New York City as certified for customs purposes by the Federal Reserve Bank of New York.

Quarter Ended		High				Low				Average				Period-End
June 30, 2002		$	1.5285			$	1.4310			$	1.4615			$	1.5245
September 30, 2002		$	1.5800			$	1.5192			$	1.5497			$	1.5700
December 31, 2002		$	1.6095			$	1.5418			$	1.5714			$	1.6095
March 31, 2003		$	1.6482			$	1.5624			$	1.6025			$	1.5790
June 30, 2003		$	1.6840			$	1.5500			$	1.6183			$	1.6529
September 30, 2003		$	1.6718			$	1.5728			$	1.6107			$	1.6620

      On November 24, 2003, the closing sales price of our common stock as reported by the London Stock Exchange was £5.63 per share, or approximately $9.59 per share based on the noon buying rate for sterling of £1.00 = $1.7051 on November 24, 2003. On November 24, 2003, the shares of our common stock were held by approximately 20 holders of record.

      We have never declared or paid any cash dividends on our capital stock. We currently intend to retain future earnings, if any, to finance the operation and expansion of our business. Therefore, we do not anticipate paying any cash dividends on our capital stock in the foreseeable future. In addition, if we were to borrow against any credit facility that we may enter into, we may be prohibited from paying cash dividends.

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CAPITALIZATION

      The following table sets forth our capitalization as of September 30, 2003:

	•	on an actual basis; and
	•	as adjusted to reflect the effect of the sale of a total of 2,000,000 common stock units in this offering at an assumed initial public offering price of $5.50 per unit, the midpoint of the range set forth on the cover of this prospectus, after deducting underwriting discounts and commissions and estimated offering expenses. See “Use of Proceeds” for more information regarding the determination of the expected net proceeds of this offering.

      This table should be read in conjunction with “Management’s Discussion and Analysis of Financial Condition and Results of Operations” and the consolidated financial statements and the notes thereto included elsewhere in this prospectus.

			As of September 30, 2003
			Actual				As Adjusted
			(in thousands)
Short-term debt
	Current portion of long-term debt			—				—
Long-term debt
	Bank borrowings			—				—
Stockholders’ equity: preferred stock, $0.01 par value, 100,000 shares authorized; no shares issued and outstanding				—				—
	Common stock, $0.00000002 par value, 113,00,000 shares authorized, 52,032,000 shares issued and outstanding actual and 54,032,000 shares issued and outstanding as adjusted
	Additional paid-in-capital			9,058				18,123
	Deficit accumulated during development stage			(4,270	)			(4,270	)
Accumulated other comprehensive income				50				50
Total stockholders’ equity				4,838				13,903
Total debt and stockholders’ equity			$	4,838			$	13,903

      This table excludes 1,355,000 shares of our common stock issuable upon exercise of our outstanding warrants and 1,159,000 shares of our common stock which were issued upon the exercise of warrants through November 24, 2003. The outstanding warrants have an exercise price of $4.00 per share and expire on November 30, 2003. This table also excludes 2,000,000 shares of our common stock that may be issued upon exercise of the warrants that are included in the units being offered by this prospectus.

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DILUTION

      If you invest in our common stock units, your interest will be diluted to the extent of the difference between the initial public offering price per share of our common stock units (attributing no value to the warrants that are included in the common stock units) and the pro forma as adjusted net tangible book value per share of our common stock immediately after this offering. Pro forma net tangible book value per share represents the amount of our total tangible assets less total liabilities, divided by the pro forma number of shares of our common stock outstanding. Investors participating in this offering will incur immediate, substantial dilution.

      Our net tangible book value at September 30, 2003, before adjustment for this offering, was approximately $4,838,000, or approximately $0.09 per share. After giving effect to the sale of 2,000,000 common stock units in this offering, at an assumed initial public offering price of $5.50 per unit, the midpoint of the range set forth on the cover page of this prospectus, and after deducting underwriting discounts and commissions and the estimated offering expenses, our as adjusted net tangible book value at September 30, 2003 would have been $13,903,000 or $0.26 per share. This represents an increase in net tangible book value of $0.17 per share to our existing stockholders and an immediate dilution (i.e., the difference between the public offering price per unit, attributing no value to the warrants that are included in the common stock units, and the net tangible book value per share adjusted for this offering) at September 30, 2003 of $5.24 per share to purchasers of the common stock units offered hereby. The following table illustrates this per share dilution:

Assumed initial public offering price per unit							$	5.50				100	%
	Net tangible book value per share at September 30, 2003		$	4,838
	Increase in net tangible book value per share attributable to the new investors			9,065
As adjusted net tangible book value per share after this offering								0.26
Dilution per share to new investors							$	5.24				95.27	%

      The above table excludes the possible exercise of our 1,355,000 outstanding warrants which have an exercise price of $4.00 per share and expire on November 30, 2003. The above table also excludes 1,159,000 shares of our common stock which were issued upon exercise of warrants through November 24, 2003.

      Assuming the underwriter’s over-allotment option is exercised in full, the net tangible book value at September 30, 2003 would have been $15,454,000, or $0.28 per share, the immediate increase in net tangible book value of shares owned by existing stockholders would have been $0.19 per share, and the immediate dilution to purchasers of the common stock units in this offering would have been $5.31 per share.

      The following table summarizes at September 30, 2003, after giving effect to the sale of 2,000,000 common stock units at an assumed initial public offering price of $5.50 per unit, the midpoint of the range set forth on the cover page of this prospectus, the number of shares of common stock purchased from us, the total consideration paid to us for those shares, attributing no value to the warrants that are included in the common stock units, and the consideration given by the existing stockholders and by the new investors assuming approximately 54,032,000 shares of our common stock are outstanding:

			Shares Purchased								Total Consideration								Average
																			Price
			Number				Percent				Amount				Percent				Per Share
			(in thousands)								(in thousands)
Existing stockholders				52,032				96			$	10,128				48			$	0.19
New investors				2,000				4				11,000				52			$	5.50
	Total			54,032				100			$	21,128				100

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SELECTED HISTORICAL CONSOLIDATED FINANCIAL DATA

      The following table shows selected historical financial data for the years ended June 30, 2003 and 2002, for the quarters ended September 30, 2003 and 2002 and for the period from December 1, 2000 (inception) through September 30, 2003. The information has been derived from our audited consolidated financial statements for the years ended June 30, 2003 and 2002 and our unaudited consolidated financial statements as of and for the quarters ended September 30, 2003 and 2002, included in this prospectus.

      The unaudited financial statements include all adjustments, consisting of normal recurring accruals, which we consider necessary for a fair presentation of our financial position and results of operations for those periods.

      The information below should be read in conjunction with “Management’s Discussion and Analysis of Financial Condition and Results of Operations,” “Risk Factors” and the consolidated financial statements and the notes thereto included elsewhere in this prospectus.

																		Period from
																		December 1, 2000
																		(inception)
										Year Ended								through
		Quarter Ended September 30,								June 30,								September 30,
		2003				2002				2003				2002				2003
		(in thousands, except share and per share dat																a) (unaudited)
		(unaudited)
Statement of Operations Data:
Interest and other income		$	21			$	43			$	145			$	7			$	173
Net loss arising during development stage		$	(1,114	)		$	(511	)		$	(3,033	)		$	(123	)		$	(4,270	)
Net loss per common share		$	(0.02	)		$	(0.01	)		$	(0.06	)		$	(0.00	)
Weighted average shares used to calculate loss per share			52,032,000				52,023,000				52,023,247				49,769,581
Common stock outstanding at period end			52,032,000				52,023,000				52,032,000				52,023,000

		September 30,
		2003				2002
		(in thousands)
		(unaudited)
Balance Sheet Data:
Cash and cash equivalents		$	6,375			$	8,575
Total assets			6,567				8,591
Stockholders’ equity			4,838				8,387

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MANAGEMENT’S DISCUSSION AND ANALYSIS OF

      The following discussion and analysis should be read in conjunction with our consolidated financial statements and the notes thereto appearing elsewhere in this prospectus. Our fiscal year ends June 30. We commenced business operations in May 2002, and as a result our financial results for the fiscal year ended June 30, 2003 represent our first full year of operations. Our discussion below also includes our financial results for the quarter ended September 30, 2003.

Results of Operations

      We are a development stage company and our business purpose is the development and commercialization of drugs for the treatment of cancer. We are presently engaged in the clinical development of the anti-cancer drug phenoxodiol, which Novogen has licensed to us. Our main focus during fiscal 2003 and in the first quarter of fiscal 2004 was to undertake human clinical testing of phenoxodiol. We do not employ any staff directly but obtain services from Novogen under a services agreement.

      We recorded a consolidated loss of $3,033,000 and $123,000 for the fiscal years ended June 30, 2003 and 2002, respectively. We recorded a consolidated loss of $1,114,000 and $511,000 for the quarters ended September 30, 2003 and 2002, respectively. We have not generated any revenues from operations since our inception. We have, however, received interest on our cash assets of $173,000 through September 30, 2003.

      Consolidated operating expenses for fiscal 2003 were $3,178,000 versus $129,000 for fiscal 2002. Our major operating expenses in 2003 included $1,060,000 of costs associated with conducting the clinical trials of phenoxodiol and $1,740,000 of costs incurred under the license agreement and the services and manufacturing agreements with Novogen including the costs of the clinical trial drug supplies. All of the $1,060,000 of clinical trial expenses is included under research and development expenses in our financial statements for fiscal 2003. Of the $1,740,000 of expenses, $955,000 is included under research and development expenses, $500,000 is included under license fees expenses and $285,000 is included under selling, general and administrative expenses in our financial statements for fiscal 2003. Our consolidated operating expenses for the quarter ended September 30, 2003 were $1,135,000 versus $554,000 for the quarter ended September 30, 2002. Our expenses increased mainly as a result of increased expenditures on our clinical trial program which increased by $474,000 for the quarter ended September 30, 2003 to $621,000 from $147,000 for the quarter ended September 30, 2002 (including the cost of phenoxodiol supplied to us by Novogen) and the provision for payment of the license fee payable to Novogen under the terms of the license agreement. Of the $1,135,000 of expenses for the quarter ended September 30, 2003, $782,000 is included under research and development expenses versus $334,000 for the quarter ended September 30, 2002, $246,000 is included under license fee expenses versus none for the quarter ended September 30, 2002 and $107,000 is included under selling, general and administrative expenses versus $220,000 for the quarter ended September 30, 2002. The decrease in selling, general and administrative expenses for the quarter ended September 30, 2003 was primarily due to reduced currency losses and a decrease in public relations expenditures. See “Certain Relationships and Related Transactions.”

	Research and Development Expenses

      Research and development expenses consist mainly of our clinical trial expenditures, our payments to Novogen for research support services under the terms of the services agreement and the cost of phenoxodiol used in the clinical trials supplied by Novogen under the terms of the manufacturing license and supply agreement. Research and development expenses amounted to $2,024,000 for the fiscal year ended June 30, 2003, $782,000 for the quarter ended September 30, 2003 and $334,000 for the quarter ended September 30, 2002. Research and development costs incurred since inception through the quarter ended September 30, 2003 amount to $2,875,000.

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      We expense our research and development costs as they are incurred and we expect our research and development costs to increase in the future as we progress the phenoxodiol clinical program.

      We have not documented our historical research and development costs or our clinical trial costs on a project by project basis. In addition, we use the research and development resources supplied by Novogen across several projects. As a result, we cannot state precisely the costs incurred for each of our clinical projects on a project by project basis.

      We expect that a large percentage of our research and development expenses in the future will be incurred in support of our current and future clinical development programs. These expenditures are subject to a number of uncertainties in timing and cost to completion.

      The duration and cost of clinical trials may vary significantly over the life of a project as a result of:

	•	the number of sites included in the trials;
	•	the length of time required to enroll suitable patients;
	•	the number of patients that participate in the trials; and
	•	the efficacy and safety profile of the product.

      Our strategy also includes the option of entering into collaborative arrangements with third parties to participate in the development and commercialization of phenoxodiol. In the event third parties have control over the clinical development process, the completion date would largely be under the control of that third party.

      As a result of these uncertainties, we are unable to determine the duration of or completion costs for our research and development projects or when and to what extent we will receive cash inflows from the commercialization and sale of phenoxodiol.

	Selling, General and Administrative Expenses

      Selling general and administrative expenses consist mainly of expenses associated with accounting and auditing, professional fees, public relations and administration fees paid to Novogen under the terms of the services agreement.

      We intend to continue the clinical development of phenoxodiol and to assess the opportunity to license other cancer drugs developed by Novogen as the opportunities arise.

Liquidity and Capital Resources

      At the end of fiscal year ended June 30, 2003, we had cash resources of $7,244,000 and at the end of the quarter ended September 30, 2003, we had cash resources of $6,375,000. Funds are invested in short-term money market accounts, pending use. The implementation of our business plan is dependent on our ability to maintain adequate cash resources to complete the clinical development program.

      In May 2002, we raised $10,092,000 through a private placement of 2,523,000 shares of common stock in conjunction with the listing of our common stock on the Alternative Investment Market of the London Stock Exchange. Total proceeds of $9,022,000 were received, net of $1,070,000 of transaction costs. The 2,523,000 shares of our common stock, which represent 4.9% of our issued common stock, were issued at $4.00 per share. Each share has an attached warrant exercisable at any time prior to November 30, 2003 with an exercise price of $4.00 per share. These funds were sufficient to progress the clinical development program that Novogen had commenced prior to licensing phenoxodiol to us and to commence new clinical trials. In June 2003, 9,000 warrants were exercised and in November 2003, an aggregate of 1,159,000 warrants were exercised. At present, a total of 1,168,000 warrants have been exercised.

      Based on our current plans, we believe that with the net proceeds of this offering, we will have sufficient funds to complete the current Phase Ib/IIa and Phase II clinical trial program, commence

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      If the Phase III clinical program, which is a multi-center study measuring efficacy in a large number of patients, is undertaken, we will require additional funds to complete the program. We are not able to reasonably estimate at this time either the amount required or when that amount will need to be raised. This will to a large extent be influenced by the number of patients enrolled in the trial, which can only be determined accurately upon completion of Phase II trials. If the Phase II trials are successful, we will seek to raise the funds required to complete Phase III trials or enter into a collaborative arrangement with a major pharmaceutical company.

      We must pay amounts to Novogen under our license agreement with Novogen when certain milestones are met, as follows:

	•	A lump sum license fee of $5,000,000 is payable to Novogen on the date when the cumulative total of all funds received from debt or equity issuances, revenue received from commercialization income, other than sales, and revenue from sales of phenoxodiol products exceeds $25,000,000.
	•	A further lump sum license fee of $5,000,000 is payable to Novogen on the later of November 1, 2003 or on the date when the cumulative total of all funds received from debt or equity issuances, revenue received from commercialization income, other than sales, and revenue from sales of phenoxodiol products exceeds $50,000,000.

      The cumulative total of funds received by us as of the date of this prospectus is $14,764,000. This amount includes $4,636,000 that we received since September 30, 2003 upon the exercise of 1,159,000 of our outstanding warrants. As a result, it is likely that the first lump sum license fee referred to above will become payable to Novogen upon consummation of this offering.

      In addition, we must pay annual license fees to Novogen under the license agreement for the calendar years ended December 31 as follows:

2003		$	1,000,000
2004		$	2,000,000
2005		$	4,000,000
Each calendar year thereafter		$	8,000,000

      Any amounts payable to Novogen under the above annual payments will be reduced for amounts we pay under the first lump sum license fee referred to above. For the fiscal year ended June 30, 2003 and the fiscal quarter ended September 30, 2003, $500,000 and $246,000, respectively, has been included as license fee expense in the consolidated statements of operations. See “Certain Relationships and Related Transactions” for more information about our license agreement with Novogen.

      We do not intend to incur any significant capital expenditures in the foreseeable future.

Critical Accounting Estimates

      The preparation of our consolidated financial statements in conformity with accounting principles generally accepted in the United States requires management to make estimates and assumptions that affect the amounts reported in the financial statements and the accompanying notes. Actual results could differ from those estimates.

      Estimates have been used in determining our expense liability under certain clinical trial contracts where services have been performed but not yet invoiced. The actual costs of those services could differ in amount and timing from the estimates used in completing the financial results.

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      Clinical trial expenses of $1,060,000 have been included in our financial statements for the year ended June 30, 2003, of which $331,000 had been accrued at June 30, 2003. Clinical trial expenses of $411,000 have been included in our financial statements for the quarter ended September 30, 2003, of which $510,000 had been accrued at September 30, 2003. These estimates are based on the number of patients in each trial and the patient treatment cycle.

      Clinical research contracts may vary depending on the clinical trial design and protocol. Generally the costs, and therefor our estimates, associated with clinical trial contracts are based on the number of patients, patient treatment cycles, the type of treatment and the outcome being measured. The length of time before actual amounts can be determined will vary depending on length of the patient cycles and the timing of the invoices by the clinical trial partners.

Recent Accounting Announcements

      Accounting pronouncements issued by the Financial Accounting Standards Board or other authoritative accounting standards groups with future effective dates are either not applicable or not significant to our consolidated financial statements.

Market Risk and Risk Management Practices

      We have established controls at the board level designed to safeguard our interests and ensure integrity in the reporting to stockholders. Our practices are in place to minimize risks that arise through our activities. These include practices that:

	•	ensure that any capital expenditure above a certain level is approved by the board;
	•	ensure that business risks are appropriately managed through an insurance and risk management program;
	•	ensure that safety, health, environmental standards and management’s systems are monitored and reviewed to achieve high standards of compliance and performance; and
	•	ensure implementation of board approved operating plans and budgets and board monitoring of progress against these budgets, including the establishment and monitoring of key performance indicators.

Impact of Inflation

      Although inflation has slowed in recent years it is still a factor that may affect our financial performance. We do not earn sales revenue and for the foreseeable future we will not be able to increase the price of goods sold to offset inflationary effects. Costs incurred in conducting clinical trials are affected by inflation as are other inputs. There is a risk that costs will increase over time due to inflation increasing the cost to us.

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BUSINESS

      We are a developmental stage pharmaceutical company and our business purpose is the development and commercialization of drugs for the treatment of cancer. We are presently engaged in the clinical development and commercialization of a drug candidate called phenoxodiol, which we believe may have broad application against a wide range of cancers. Phenoxodiol appears to target a number of key components involved in cancer cell survival and proliferation based on the emerging field of signal transduction regulation, with little or no effect on normal cells. We have attached as Annex A, a glossary of technical and scientific terms that we use in this prospectus.

      Novogen Limited, an Australian company publicly traded on the Nasdaq National Market, owns approximately 93.1% of our outstanding common stock and, after this offering, will own approximately 89.7% of our common stock. We were incorporated as a separate subsidiary of Novogen to focus on the development and commercialization of drugs for the treatment of cancer and were not incorporated primarily as a finance vehicle. In contrast, Novogen has a broader business focus which, in addition to the business conducted by us, includes a consumer health division that focuses on the development of a range of non-prescription products for the health needs of both men and women and a pharmaceutical division which focuses on the development of prescription drugs. We were established by Novogen to advance Novogen’s research on one specific degenerative disease, cancer. We believe that Novogen’s corporate structure, with us functioning as a corporate entity separate from Novogen’s other lines of business, has provided us with:

	•	Greater strategic focus on the development of phenoxodiol and other cancer drugs with dedicated financial resources;
	•	Direct access to the capital markets and investors who focus on the development of cancer drugs and the ability to raise debt or equity should additional funding be required in the future; and
	•	The ability to offer equity interests, co-development rights and other arrangements to strategic partners who focus on the treatment and prevention of cancer market.

Scientific Overview

      Phenoxodiol belongs to a class of drugs that we refer to as Multiple Signal Transduction Regulators (MSTRs).

      Signal transduction refers to the means by which cells respond to chemical signals that come from within the cell itself, from neighboring cells, and from elsewhere in the body. These signals regulate such vital functions as the growth and survival of the cell. We believe that malfunctions in key components of the signal transduction process (whereby a series of chemical signals within a cell leads to the expression of a particular function) are fundamental to degenerative diseases such as cancer, where cells respond abnormally to normal levels of signals, typically by over-responding to them with increased cell growth and survival.

      We believe that identifying malfunctions in the signal transduction process and then designing drugs to block or correct them has become a basis for the development of the next generation of anti-cancer drugs. These drugs have become known as signal transduction inhibitors. These drugs are being designed to target a specific signaling pathway which typically is over-active in a tumor cell, and by blocking its progression, so to prevent or reduce the ability of the tumor cell to divide or to survive. We believe that signal transduction inhibitors, while displaying anti-tumor activity against a small number of different types of cancer, generally have failed to provide more than modest prolongation of survival of cancer patients. We believe this is because most human cancers involve errors of multiple signaling pathways, and inhibition of a single pathway by any one drug alone cannot reasonably be expected to provide more than a temporary halt to cancer progression.

      Based on our clinical studies, we believe phenoxodiol increases the potency of signal transduction inhibitors by targeting multiple signaling pathways, and in particular, those pathways vital to the survival of most, if not all, human cancer cells. In the term MSTR, “multiple” refers to the fact that more than one

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      We believe that phenoxodiol targets a number of key components involved in cancer cell survival and proliferation of signal transduction processes. For example, phenoxodiol appears to target enzymes called kinases that catalyze phosphorylation of acceptor molecules. These kinases appear to be involved in signaling related to cell survival and cell growth (e.g. sphingosine kinase, a kinase believed to be important to both cell survival and cell growth). Inhibition of these targets results in increased cancer cell death and cancer cell cytostasis (the inhibition of cell growth or division).

      This disrupting effect of phenoxodiol is restricted to tumor cells, with non-tumor cells remaining unaffected. A potential explanation for this selective anti-tumor effect was provided by a recent discovery of a research team at Purdue University. The research team discovered that phenoxodiol targets a particular member of the ECTO-NOX family of proteins. This family of proteins regulates fundamental biological processes at the cell surface that are vital to the survival and growth of all living matter. One of these proteins, known as constitutive NADH oxidase (CNOX) is a fundamental source of hydrogen ions for all living cells. The Purdue University studies have now shown that all forms of human cancer express a variant form of CNOX, known as tNOX. The presence of tNOX disrupts the normal pattern of behavior of the cell, contributing to the unregulated cell growth and survival that characterizes tumor cells. This makes tNOX the first pan-cancer expressed protein, identifying it as a potentially important new target for anti-cancer drug development. Phenoxodiol appears to specifically block the action of tNOX, with the resulting inhibition of H+ influx into the cell, leading to extensive disruption to signaling pathways and to eventual apoptosis, which is the process of programmed cell death by which a cell dies naturally. Phenoxodiol has no effect on CNOX, providing an explanation of how phenoxodiol can be so selective in its action, with its cytotoxic effects being limited to cancer cells.

      Laboratory studies at Yale University also have revealed that the killing effect of phenoxodiol of cancer cells occurs through the caspase enzyme pathway, and that key triggers of this proteolytic pathway are the up-regulation of production in the cancer cell of pro-apoptotic factors such as Bax and the increased degradation of anti-apoptotic factors such as c-FLIP and XIAP. The latter effect facilitates death of cancer cells via either the Fas or TRAIL death receptor mechanisms, each of which is a signaling molecule that when activated causes cell death. Some aspects of this function were published recently in the Nature journal, Oncogene.

      Recent laboratory studies conducted by Novogen and Yale University have revealed that phenoxodiol interacts well with a number of standard anti-cancer drugs such as cisplatin, gemcitabine and taxanes. In one aspect of this effect, phenoxodiol appears to restore sensitivity to these drugs in cells such as ovarian cells that have acquired resistance to such drugs. In another aspect, pretreatment of tumor cells with phenoxodiol considerably increases the sensitivity of virgin tumor cells to the cytotoxic effects of standard chemotoxic drugs. Both of these effects are achieved without increasing the toxicity of the standard chemotoxic drugs to non-tumor cells.

Market Opportunity

      The American Cancer Society, or ACS, has reported that, in the year 2003, approximately 1,344,100 new cancer cases are expected to be diagnosed in the United States and that since 1990, approximately 17 million new cancer cases have been diagnosed. The ACS has also reported that 556,500 people in the United States are expected to die from cancer this year.

      The primary focus in the development of phenoxodiol is currently in connection with ovarian cancer, squamous cell carcinoma, or SCC of the cervix, vagina, vulva and skin, and prostate cancer. Subject to further successful clinical research and development, we believe that phenoxodiol may have potential uses in other forms of human cancers as well as in combinational therapy with other anti-cancer drugs.

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      The cancers for which phenoxodiol is intended to be used are relatively common. The ACS has estimated that in 2003 there will be 220,900 new cases of prostate cancer and 28,900 people will die as a result of this cancer in the United States. The ACS has also estimated that in 2003 there will be 25,400 new cases of ovarian cancer diagnosed and 14,300 will die as a result of this cancer in the United States. For SCC of the cervix, vagina and vulva, the ACS estimates that in the year 2003, there will be 18,200 new cases diagnosed and that there will be 5,700 deaths caused by these cancers in the United States. The ACS estimates that 2,200 deaths will occur in the United States as a result of cutaneous SCC.

      The treatment of prostate cancer depends on age, stage of the cancer, and other medical conditions of the patient. Current treatment options include surgery, radiation, hormonal therapy or chemotherapy (or a combination of these treatments) depending on the stage of the disease. Survival rates also depend on the stage of the disease. However, there is a low survival rate associated with advanced disease.

      Treatment options for ovarian cancer include surgery, radiation therapy and chemotherapy. Treatment in advanced cases is associated with low survival rates.

      SCC is a common type of cancer found in the skin and mucous membranes of the body. Cancers of the cervix, vagina and vulva are mostly of the SCC type and are recognized for their poor response to standard chemotherapy. Surgery remains the treatment of choice for these cancers and treatment in advanced cases is associated with low survival rates. Cutaneous SCC is a relatively common form of skin cancer. It is most common in sun-exposed areas and if left untreated can invade locally, requiring extensive surgery.

Overall Clinical Development Strategy

      Based on the clinical and pre-clinical work conducted on phenoxodiol, we believe that based on its mode of action, phenoxodiol has the potential ultimately to become a treatment option for a wide range of human cancers, and to be employed at various stages of cancer development ranging from early-stage cancer through to late-stage cancer.

      The immediate priority, is to focus on those therapeutic indications that will expedite drug marketing approval of phenoxodiol by regulatory bodies. To this end, we will continue our work in late-stage chemo-resistant cancers including completing our current intravenous monotherapy ovarian cancer clinical trial currently underway at Yale University. Pending the outcome of this trial we intend to expend our intravenous program to include combinational therapy using phenoxodiol in combination with standard chemotherapy drugs in cancers which have become chemo-resistant. In chemo-resistant cancers we hope to show that phenoxodiol will provide in humans what it has demonstrated in the laboratory and in animal models, that is, the restoration of chemo-sensitivity to standard chemotoxic agents. In this way, phenoxodiol will be used to “condition” the tumor cells to the more destructive effects of drugs such as cisplatin, gemcitabine and taxanes, with the combined effects of all drugs providing a potent force able to attack well-established and extensive cancer disease. In the next stage of our clinical development program for phenoxodiol in the area of chemo-resistant cancers, it is possible that other forms of cancer (such as renal carcinoma, head and neck cancer), generally regarded as unresponsive to standard drugs, will be added to this program in due course in order to maximize the opportunity for treating chemo-resistant cancers.

      A secondary priority is to develop phenoxodiol for use in earlier-stage cancers. This is the basis of the planned clinical program involving oral phenoxodiol in SCC of the cervix, vagina, vulva, including our planned adjuvant trial at Yale University, and skin, and prostate cancer. These are all forms of cancer for which early diagnosis is commonly available, and for which a non-invasive, non-surgical drug option might be an attractive therapeutic option. In this strategy, phenoxodiol is being studied in the first instance as an oral monotherapy in the expectation that phenoxodiol alone will provide an adequate anti-cancer effect.

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Specific Objectives

      Our current objectives are to:

	•	complete the Phase Ib/IIa and Phase II clinical programs currently being undertaken for phenoxodiol as a monotherapy;
	•	commence a Phase II study in patients with late-stage, chemo-resistant ovarian cancer that will use phenoxodiol in combination with standard anti-cancer drugs; and
	•	commence Phase II studies for phenoxodiol as a monotherapy, targeting early-stage cancer of the cervix, vagina and vulva, and prostate cancer.

      We anticipate that with the proceeds of this offering we will have sufficient funds for these activities. The success and timing of the clinical trials could vary significantly from current estimates. A delay in any one phase of trials is likely to delay following phases. Our long-term objectives will be to:

	•	commence Phase III clinical trials for phenoxodiol as both a monotherapy for early-stage cancers and for use in combinational therapy for later-stage cancers;
	•	seek to develop relationships with strategic partners for the development, marketing and distribution of phenoxodiol as a treatment for those cancer indications for which regulatory approval is obtained;
	•	potentially expand the uses of phenoxodiol to treat other cancers; and
	•	pursue appropriate opportunities to develop and commercialize other anti-cancer compounds.

      We will require additional funding in order to undertake our long-term objectives.

History of Phenoxodiol Development

      In 1995, phenoxodiol was identified as a potential intermediate in the metabolism of daidzein, a naturally occurring isoflavone. Isoflavones are a family of structurally related molecules found in foods such as legumes, red clover, lentils and chickpeas. To date, phenoxodiol has not appeared to have been isolated or identified in mammals.

      Novogen scientists first synthesized phenoxodiol in 1997 as part of a program of drug discovery based on the structure of naturally occurring isoflavones. When screened for anti-cancer action against human cancer cells in vitro (in the laboratory), phenoxodiol was found to be cytostatic and cytotoxic against a wide range of human cancer cells, but without toxicity against non-tumor cells. In vivo (in animals) studies in laboratory animals subsequently showed that phenoxodiol administered either orally or systemically was adequately bioavailable (absorbed into the body in useful form) and significantly retarded tumor development, in particular in athymic mice bearing xenografts of human prostate cancer. Such anti-cancer effects in animals were achieved without evidence of toxicity, and thus phenoxodiol was selected for development as a human anti-cancer drug.

      Subsequent pre-clinical studies identified a range of molecular targets of phenoxodiol within human cancer cells, prompting us to classify the drug as a Multiple Signal Transduction Regulator.

      The broad anti-cancer action of phenoxodiol against an extensive library of different human cancer cell lines (prostate, breast, ovarian, lung and cervical cancer, mesothelioma, melanoma, glioma and rhabdomyosarcoma), suggested potential clinical application against a wide range of types of human cancer. Further pre-clinical studies showed that phenoxodiol has a number of indirect anti-cancer effects (a potent ability as an anti-androgen, which is a process that reduces the biological impact of male sex hormones like testosterone, and an ability to induce apoptosis of hyperplastic prostate smooth muscle cells, the main type of stromal cells found in the prostate gland) that suggested prostate cancer as a particularly suitable clinical target, leading to this form of cancer being identified early as a prime potential clinical target for the drug. However, with a view to allowing further time to identify the most sensitive types of cancer to phenoxodiol, the strategy adopted was to conduct Phase I studies in patients with a wide

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      Phase Ia pharmacokinetic studies, which monitor the behavior of a drug within the body, conducted in cancer patients in May 2000 showed that phenoxodiol behaved similarly to steroidal hormones and was prone to conjugation (glucuronide and sulfates) within the body. These conjugated forms are the means by which a water-insoluble drug such as phenoxodiol is transported within the body. Conversion of these drugs to the active form requires deconjugation by relevant enzymes within end tissues to yield the bioactive (unconjugated) drug form. Bioequivalence studies showed that phenoxodiol is considerably more prone to conjugation when administered orally (greater than 99%) compared to intravenously (approximately 85%). Therefore, in the absence of definitive data on the rates of expression of deconjugating enzymes by different tumor types, it was decided to commence clinical studies with an intravenous dosage form of phenoxodiol because of the certainty of obtaining levels of unconjugated phenoxodiol in the plasma, the liquid component of blood, that were known in the laboratory to be highly cytotoxic to cancer cells.

      A Phase Ib toxicity study was commenced in Australia in November 2000 and finished in March 2002. Twenty-one patients with late-stage solid cancers (any type) were given phenoxodiol by weekly bolus injections, which are intravenous injections delivered quickly (usually over several minutes), for 12 weeks. This was a dose-escalating study, with inter-patient escalation from 1 to 30 mg/kg/dose. No dose-limiting toxicity was reached and no significant toxicities other than some hypersensitivities to the drug vehicle (cyclodextrin) were encountered.

      A second Phase Ib toxicity study commenced in Australia in April 2001 and concluded in 2002. Twenty-one patients with late-stage solid cancers (any type) were given phenoxodiol by continuous intravenous infusion. This was a dose-escalating study, with inter-patient escalation from 1 to 40 mg/kg/day. No dose-limiting toxicity was reached and no significant toxicities were encountered.

      An IND for the intravenous dosage form of phenoxodiol became effective in January 2001, allowing a third Phase Ib toxicity study to commence at The Cleveland Clinic, Ohio, in August 2001. This study concluded in 2002. Nineteen patients with late-stage solid cancers (any type) were given phenoxodiol by continuous intravenous infusion. This was a dose-escalating study, with inter-patient escalation from 0.5 to 64 mg/kg/day. No dose-limiting toxicity was reached and no significant toxicities were encountered.

      Concurrent with the Phase I clinical trial program outlined above, pre-clinical studies continued with a view to better understanding the molecular targets of phenoxodiol and the most appropriate tumor types for therapy. In terms of molecular targets, a number of important actions were identified:

	•	that phenoxodiol has broad inhibitory activity against kinase enzymes, resulting in disruption to a wide range of signaling pathways involved in cell survival and growth;
	•	that phenoxodiol-induced apoptosis occurred via the caspase cascade;
	•	that phenoxodiol-induced apoptosis was initiated as a result of activation of death receptor (Fas, TRAIL) mechanisms and down-regulation of death receptor blockers (c-FLIP, XIAP); and
	•	that a key molecular target is the receptor protein, tNOX, whose inhibition leads to extensive disruption of pro-survival mechanisms.

      A further key pre-clinical finding was that phenoxodiol was particularly effective against ovarian cancer, melanoma and mesothelioma cell lines that were resistant to all standard chemotoxic anti-cancer drugs, pointing to the usefulness of phenoxodiol at least in patients with these cancers who had failed all other forms of chemotherapy.

      The selection of specific tumor types in which to test phenoxodiol in Phase II clinical trials was based on a number of factors. First, the known relevance of certain actions of phenoxodiol (e.g., the targeting of death receptor activity) to the survival of certain cancer cell types; second, pre-clinical experience with the use of phenoxodiol in animals bearing human tumor xenografts; and third, observations of clinical

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      A team of scientists at Yale University School of Medicine commenced a Phase II study in October 2002 of the intravenous dosage form of phenoxodiol in 40 patients with ovarian cancer. We expect that we will receive interim results from this study by the end of this year.

      Novogen decided to pursue the clinical applications in prostate cancer and SCC using the oral dosage form of the drug. This followed the trial use of the oral dosage form in a number of patients who had completed the Phase I trials of the intravenous dosage form of phenoxodiol. The oral dosage form was found capable of prolonging survival in patients with advanced disease despite the presence of phenoxodiol in the blood in an almost completely conjugated form. It appears that certain types of tumors may have the capacity to deconjugate phenoxodiol conjugates to the active drug form. Clinical trials on the oral dosage form of phenoxodiol began in Australia in January 2002. This dosage form currently is being evaluated in Australian hospitals in Phase II clinical trials for the treatment of prostate cancer and SCC.

      An IND for the oral dosage form of phenoxodiol became effective in June 2003, which cleared the way to commence a study in collaboration with Yale University School of Medicine in patients with cancer of the cervix, vulva and vagina. Phenoxodiol will be used on a monotherapy basis in patients following a primary diagnosis of cancer. Phenoxodiol will be administered daily for periods of up to 4 weeks prior to surgery or radiotherapy.

      A Phase Ib/IIa study began in early 2002 on the use of phenoxodiol in patients with hematological tumors, in an attempt to test the usefulness of phenoxodiol in non-solid tumors. However, the apparent sensitivity of certain solid tumors to phenoxodiol and the need to focus resources on those clinical opportunities mean that an application in hematological tumors is unlikely to be taken further.

	Phenoxodiol and Ovarian Cancer

      A team of scientists at Yale University School of Medicine is currently conducting a Phase II clinical study. The study is fully enrolled, using 40 patients with advanced, metastatic ovarian cancer that has become unresponsive to at least two standard chemotherapies (the average number of different drug regimes used previously in these patients is five per patient). Phenoxodiol is being administered as a monotherapy by bolus intravenous injection on two consecutive days per week in rising dosages (one, three, 10 and 20 mg/kg/24-hr) to four groups, each of 10 women, over treatment cycles of 12 weeks. Tumor response is being assessed on the basis of tumor mass, levels of the tumor marker (CA125) in the blood, survival over 12 months, and quality of life.

      This clinical trial is based on laboratory studies at Yale University School of Medicine that showed phenoxodiol to be the most effective drug at killing ovarian cancer cells, including those that are resistant to all standard anti-cancer drugs.

      Following analysis of the data from the current Phase II study, currently projected to be completed by December 2003, a decision will be made concerning the next stage.

      A recent pre-clinical study also extended these findings by showing that phenoxodiol proved highly effective at restoring ovarian cancer cells’ sensitivity to standard anti-cancer drugs such as cisplatin. Cisplatin is a standard drug used in the treatment of ovarian cancer, but patients’ tumors commonly become resistant to this drug after some months. A combination of phenoxodiol and cisplatin proved highly effective in stopping human ovarian cancer growth in animals with doses of phenoxodiol and cisplatin that alone were ineffective. This raises the prospect of obtaining an enhanced clinical response of phenoxodiol by combining it with standard chemotherapies, and the opportunity to conduct a combinational drug trial in ovarian cancer patients is currently under review.

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	Phenoxodiol and Prostate Cancer

      Two Australian hospitals are currently conducting a study testing the effect of oral phenoxodiol therapy in patients with late-stage prostate cancer that has become unresponsive to hormonal therapy. Phenoxodiol is being administered orally three times per day on a daily basis over treatment cycles of 12 weeks. There will be 24 patients in this trial, with patients being allocated to seven different dose levels (from 0.72 to 9.0 mg per 24-hr). The study currently has 18 patients enrolled.

	Phenoxodiol and Cutaneous SCC

      The potential for phenoxodiol in the treatment of cutaneous SCC arose from the observation that in patients being treated for other forms of cancer who coincidentally had aggressive, malignant SCC of the skin, the SCC tumors showed objective responses within several weeks. A Phase II trial is being conducted at an Australian hospital in 30 patients with malignant SCC of the skin. Phenoxodiol is being administered orally, three times daily for a period of three months. We anticipate this study being completed by the third quarter of 2004.

Competition

      The clinical development and commercialization of new anti-cancer drugs is highly competitive. As a developmental stage pharmaceutical company, we compete with pharmaceutical and biotechnology companies, academic and scientific institutions, governmental agencies and public and private research organizations.

      Many pharmaceutical and biotechnology companies have products or drug candidates in various stages of pre-clinical or clinical development to treat prostate cancer, ovarian cancer, SCC and other cancers. Some of these potentially competitive drugs are further advanced in development and may receive FDA or other regulatory approval and may be commercialized earlier than phenoxodiol. Some of these drugs may be directly competitive with phenoxodiol to the extent that they would obviate the need for phenoxodiol. In other cases, however, these drugs or therapies may not be competitive to the extent that they are not mutually exclusive and could be used in conjunction with phenoxodiol.

      Many pharmaceutical and biotechnology companies are developing drugs specifically in the area of signal transduction inhibition. Several such drugs have received marketing approval over the past five years. While much of the activity in this field is based on rational drug design, meaning that the nature of action of such drugs is overwhelmingly focused on individual signaling targets, it would be reasonable to expect that attention will be drawn increasingly to the development of drugs like phenoxodiol that have activity against multiple targets.

      Iressa, a signal transduction inhibitor manufactured by AstraZeneca, is a potential competing treatment and has recently been granted FDA approval for use in the treatment of advanced stage non-small cell lung cancer in patients who have already received specific chemotherapy. Other potential competition might arise from the development of drugs with a related chemical heritage to phenoxodiol. Genistein and flavopiridol^TM are two chemicals with a related chemical heritage of an underlying flavonoid chemical structure which are undergoing clinical development as anti-cancer agents. Our understanding is that genistein is in Phase II clinical studies, while we believe flavopiridol^TM, under development by Aventis, is in Phase III clinical studies.

      Our competitors may develop and commercialize products that are safer, less costly and more efficacious in the treatment of cancers. In addition, we and Novogen, our services provider, face and will continue to face competition from companies, institutions, agencies and organizations, including those in fields unrelated to drug development, to recruit qualified personnel, attract partners for joint ventures and license competitive technologies.

      Many of our competitors have significantly greater capital resources, larger research and development staffs and facilities and greater experience in drug development, regulation, manufacturing and marketing than we do at present. Aventis, which is developing flavopiridol^TM, and AstraZeneca, which has been

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Intellectual Property

      Novogen has been granted patents and has additional patents pending in a number of countries which cover a family of chemically related compounds with potentially broad ranging and complementary anti-cancer effects. Novogen has granted to us an exclusive license with respect to its patent rights and intellectual property know-how to develop, market and distribute one of these compounds, phenoxodiol, as an anti-cancer agent, except in topical form.

      See “Certain Relationships and Related Transactions” for more information regarding our agreements with Novogen.

      We have licensed from Novogen the rights to the Novogen patents and applications as they relate to phenoxodiol as an anti-cancer agent. Excluded from these rights is phenoxodiol in a topical formulation. The patent rights we have licensed from Novogen can be largely classified into two broad groups: patent rights relating to phenoxodiol used as an anti-cancer agent, which we refer to as “product patent rights”, and patent rights relating to the manufacture of phenoxodiol for anti-cancer purposes, which we refer to as “manufacturing patent rights”. The pending and issued Novogen patent rights can be further broken down into four families, three families belonging to the product patent rights and one family belonging to the manufacturing patent rights: The three families in the product patent rights comprise phenoxodiol for the treatment of cancer (16 pending; seven issued); compositions and methods for protecting skin from ultraviolet induced immunosuppression and skin damage including phenoxodiol (10 pending; three issued); therapeutic methods and compositions involving isoflav-3-ene and isoflavan structure including phenoxodiol (PCT pending). The family relating to the manufacturing patent rights relate to the production of isoflavone derivatives including phenoxodiol (17 pending).

      Novogen has recently been granted a U.S. Patent (No. 6,649,648), a product patent, by the United States Patent and Trademark Office (USPTO) relating to the treatment of any cancerous disease with phenoxodiol, including ovarian cancer, breast cancer, prostate cancer and metastatic cancer.

      As patent applications in the United States are sometimes maintained in secrecy until published or issued and as publication of discoveries in the scientific or patent literature often lag behind the actual discoveries, we cannot be certain that Novogen was the first to make the inventions covered by the Novogen patents and applications as they relate to phenoxodiol as an anti-cancer agent referred to above. Moreover, pursuant to the terms of the Uruguay Round Agreements Act, patents filed on or after June 8, 1995 have a term of twenty years from the date of such filing, irrespective of the period of time it may take for such patent to ultimately issue. This may shorten the period of patent protection afforded to phenoxodiol as patent applications in the biopharmaceutical sector often take considerable time to issue. Under the Drug Price Competition and Patent Term Restoration Act of 1984 (the “Patent Act”), a sponsor may obtain marketing exclusivity for a period of time following FDA approval of certain drug applications, regardless of patent status, if the drug is a new chemical entity or if new clinical studies were used to support the marketing application for the drug. Pursuant to the FDA Modernization Act of 1997, the period of exclusivity can be extended if the applicant performs certain studies in pediatric patients. This marketing exclusivity prevents a third party from obtaining FDA approval for an identical or nearly identical drug under an Abbreviated New Drug Application (“ANDA”) or a “505(b)(2)” New Drug Application. The statute also allows a patent owner to obtain an extension of applicable patent terms for a period equal to one-half the period of time elapsed between the filing of an IND and the filing of the corresponding New Drug Application (NDA) plus the period of time between the filing of the NDA and FDA approval, with a five year maximum patent extension. We cannot be certain that Novogen will be able to take advantage of either the patent term extension or marketing exclusivity provisions of this law.

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      In order to protect the confidentiality of our technology, including trade secrets and know-how and other proprietary technical and business information, we require all of our consultants, advisors and collaborators to enter into confidentiality agreements that prohibit the use or disclosure of information that is deemed confidential. The agreements also oblige our consultants, advisors and collaborators to assign to us developments, discoveries and inventions made by such persons in connection with their work with us. We cannot be sure that confidentiality will be maintained or disclosure prevented by these agreements or that our proprietary information or intellectual property will be protected thereby or that others will not independently develop substantially equivalent proprietary information or intellectual property.

      The pharmaceutical industry is highly competitive and patents have been applied for by, and issued to, other parties relating to products competitive with phenoxodiol. Therefore, phenoxodiol and any other drug candidates may give rise to claims that they infringe the patents or proprietary rights of other parties existing now and in the future. An adverse claim could subject us to significant liabilities to such other parties and/or require disputed rights to be licensed from such other parties. We cannot be sure that any license required under any such patents or proprietary rights would be made available on terms acceptable to us, if at all. If we do not obtain such licenses, we may encounter delays in product market introductions, or may find that the development, manufacture or sale of products requiring such licenses may be precluded. We have not conducted any searches or made any independent investigations of the existence of any patents or proprietary rights of other parties.

Relationship with Novogen

      Novogen has been granted patents and has additional patent applications pending in a number of countries pertaining to phenoxodiol’s family of compounds and to phenoxodiol itself and their use in anti-cancer therapeutics. Novogen has granted us an exclusive license under its patent rights and the intellectual property rights in its relevant know-how to develop, market and distribute all forms of administering phenoxodiol for anti-cancer applications, except topical applications.

      Novogen is active in the discovery and development of new drugs based on the emerging field of signal transduction regulation. Signal transduction regulators offer the potential for effective, well-tolerated treatment of common degenerative diseases including cancer and heart disease. Novogen has developed a family of chemically related compounds with potentially broad ranging and complementary anti-cancer effects.

      We have entered into certain key agreements with Novogen. These agreements are discussed briefly below. Investors should also read the detailed summary of these documents set out in “Certain Relationships and Related Transactions.”

      Under the license agreement, Novogen granted us an exclusive world-wide, non-transferable license, under the Novogen patent rights, to conduct clinical trials and commercialize and distribute all forms of administering phenoxodiol except topical applications. The agreement covers uses of phenoxodiol in the field of prevention, treatment or cure of cancer in humans. Our business is currently focussed on advancing the clinical program underway for the development of phenoxodiol.

      Under the manufacturing license and supply agreement, Novogen assumes responsibility for the supply of phenoxodiol in its primary manufactured form for both the research and development program and phenoxodiol’s ultimate commercial use. Novogen has a pilot phenoxodiol manufacturing plant which we believe has sufficient capacity to meet the projected amount of phenoxodiol required to complete the proposed clinical program.

      Under the license option deed, Novogen granted us an exclusive first right to accept and an exclusive last right to match any proposed dealing by Novogen with its intellectual property rights in other synthetic compounds developed by Novogen that have known or potential anti-cancer applications in all forms other than topical applications.

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      Pursuant to the services agreement, Novogen provides services reasonably required by us relating to the development and commercialization of phenoxodiol. We do not currently intend to directly employ any staff and are reliant on Novogen for the provision of resources to conduct our business.

Commercialization

      Commercialization of a drug requires approval from the regulatory body of each country in which the drug is to be marketed. Following the completion of Phase III studies, the data gathered from the clinical trial program must be collated for presentation to the appropriate regulatory authorities in each territory in a form acceptable to each authority, in order to obtain the relevant regulatory approvals to market the drug in that territory. Approval usually is granted for those specific cancer indications for which the clinical data supports efficacy.

      We may choose to seek regulatory approval in our own right in any or all territories. Alternatively, we may seek to establish a strategic partnership with another pharmaceutical company to market phenoxodiol in certain territories, in which case that partner may take responsibility for application for regulatory approval.

      Successful commercialization requires high quality marketing campaigns and distribution arrangements in order to gain market share as fast as possible. Global pharmaceutical companies have large and professional marketing and distribution functions that regularly introduce new drugs throughout the world. For that reason, we are likely to choose to seek a strategic partnership in any or all territories in which phenoxodiol is to be marketed. Our decision to establish a strategic partnership will depend on the success of phenoxodiol during the clinical program, the level of funding required to complete the clinical program to gain marketing approval and whether we can negotiate favorable terms with potential partners.

      Decisions on both the appropriate territories in which regulatory approval will be sought and the nature of commercialization in those territories will be made by the board of directors at the appropriate time and with due regard to maximizing the commercial benefit to us.

      The most significant market for phenoxodiol is the United States market. Before a drug is granted regulatory approval to be marketed and commercialized in the United States, the drug must gain approval to be tested in humans. In the United States, this requires the drug to have an effective IND. See “— Regulation-U.S. Regulatory Requirements.” Phenoxodiol has achieved this status and has commenced clinical trials in the United States.

Research and Development

      The objective of our research and development program is the generation of data sufficient to achieve regulatory approval of phenoxodiol in one or more dosage forms in major markets such as the United States, and/or to allow us to enter into a commercial relationship with another party. The data is generated by our clinical trial programs.

      The key aspects of this program are to provide more complete characterization of the following:

	•	the relevant molecular targets of action of phenoxodiol;
	•	the relative therapeutic indications of different dosage forms of phenoxodiol;
	•	the relative therapeutic benefits and indications of phenoxodiol as a monotherapy or as part of combinational therapy with other chemotoxics; and
	•	the most appropriate cancer targets for phenoxodiol.

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Regulation

	U.S. Regulatory Requirements

      The U.S. Food and Drug Administration, or FDA, and comparable regulatory agencies in foreign countries regulate and impose substantial requirements upon the research, development, pre-clinical and clinical testing, labeling, manufacture, quality control, storage, approval, advertising, promotion, marketing, distribution, and export of pharmaceutical products, including biologics, as well as significant reporting and record-keeping obligations. State governments may also impose obligations in these areas.

      In the United States, pharmaceutical products are regulated by the FDA under the Federal Food, Drug, and Cosmetic Act, or FDCA, and other laws, including in the case of biologics, the Public Health Service Act. We believe, but cannot be certain, that our products will be regulated as biologics and drugs by the FDA. The process required by the FDA before biologics or drugs may be marketed in the United States generally involves the following:

	•	pre-clinical laboratory evaluations, including formulation and stability testing, and animal tests performed under the FDA’s Good Laboratory Practices regulations to assess potential safety and effectiveness;
	•	submission and approval of an IND, including results of pre-clinical tests and protocols for clinical tests, which must become effective before clinical trials may begin in the United States;
	•	obtaining approval of Institutional Review Boards to administer the products to human subjects in clinical trials;
	•	adequate and well-controlled human clinical trials to establish the safety and efficacy of the product for the product’s intended use;
	•	development of manufacturing processes which conform to FDA current Good Manufacturing Practices, or cGMPs, as confirmed by FDA inspection;
	•	submission of pre-clinical and clinical test results, and chemistry, manufacture and control information on the product to the FDA in a New Drug Approval Application, or NDA; and
	•	FDA review and approval of an NDA, prior to any commercial sale or shipment of a product.

      The testing and approval process requires substantial time, effort, and financial resources, and we cannot be certain that any approval will be granted on a timely basis, if at all.

      The results of the pre-clinical tests, together with initial specified manufacturing information, the proposed clinical trial protocol, and information about the participating investigators, are submitted to the FDA as part of an IND, which must become effective before we may begin human clinical trials. Additionally, an independent Institutional Review Board at each clinical trial site proposing to conduct the clinical trials must review and approve each study protocol and oversee conduct of the trial. An IND becomes effective 30 days after receipt by the FDA, unless the FDA, within the 30-day period, raises concerns or questions about the conduct of the trials as outlined in the IND and imposes a clinical hold. If the FDA imposes a clinical hold, the IND sponsor must resolve the FDA’s concerns before clinical trials can begin. Pre-clinical tests and studies can take several years to complete, and there is no guarantee that an IND we submit based on such tests and studies will become effective within any specific time period, if at all.

      Human clinical trials are typically conducted in three sequential phases that may overlap:

	•	Phase I: The drug is initially introduced into healthy human subjects or patients and tested for safety and dosage tolerance. Absorption, metabolism, distribution, and excretion testing is generally performed at this stage.
	•	Phase II: The drug is studied in controlled, exploratory therapeutic trials in a limited number of subjects with the disease or medical condition for which the new drug is intended to be used in

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		order to identify possible adverse effects and safety risks, to determine the preliminary or potential efficacy of the product for specific targeted diseases or medical conditions, and to determine dosage tolerance and the optimal effective dose.
	•	Phase III: When Phase II studies demonstrate that a specific dosage range of the drug is likely to be effective and the drug has an acceptable safety profile, controlled, large-scale therapeutic Phase III trials are undertaken at multiple study sites to demonstrate clinical efficacy and to further test for safety in an expanded patient population.

      We cannot be certain in that we will successfully complete Phase I, Phase II, or Phase III testing of our products within any specific time period, if at all. Furthermore, the FDA, the Institutional Review Board or we may suspend or terminate clinical trials at any time on various grounds, including a finding that the subjects or patients are being exposed to an unacceptable health risk.

      Results of pre-clinical studies and trials, as well as detailed information about the manufacturing process, quality control methods, and product composition, among other things, are submitted to the FDA as part of an NDA seeking approval to market and commercially distribute the product on the basis of a determination that the product is safe and effective for its intended use. NDAs are used for products that are regulated as drugs, such as synthetic chemicals. Before approving an NDA, the FDA will inspect the facilities at which the product is manufactured and will not approve the product unless cGMP compliance is satisfactory. If applicable regulatory criteria are not satisfied, the FDA may deny the NDA or require additional testing or information. As a condition of approval, the FDA also may require post-marketing testing or surveillance to monitor the product’s safety or efficacy. Even after an NDA is approved, the FDA may impose additional obligations or restrictions (such as labeling changes), or even suspend or withdraw a product approval on the basis of data that arise after the product reaches the market, or if compliance with regulatory standards is not maintained. We cannot be certain that any NDA we submit will be approved by the FDA on a timely basis, if at all. Also, any such approval may limit the indicated uses for which the product may be marketed. Any refusal to approve, delay in approval, suspension or withdrawal of approval, or restrictions on indicated uses could have a material adverse impact on our business prospects.

      Each NDA must be accompanied by a user fee, pursuant to the requirements of the Prescription Drug User Fee Act, or PDUFA, and its amendments. According to the FDA’s fee schedule, effective on October 1, 2003 for the fiscal year 2004, the user fee for an application requiring clinical data, such as an NDA, is $573,500. The FDA adjusts the PDUFA user fees on an annual basis. PDUFA also imposes an annual product fee for prescription drugs and biologics ($36,080 for the fiscal year 2004), and an annual establishment fee ($226,800) on facilities used to manufacture prescription drugs and biologics. We are not at the stage of development with our products where we are subject to these fees, but they are significant expenditures that will be incurred in the future and must be paid at the time of application submission to the FDA.

      Satisfaction of FDA requirements typically takes several years. The actual time required varies substantially, based upon the type, complexity, and novelty of the pharmaceutical product, among other things. Government regulation imposes costly and time-consuming requirements and restrictions throughout the product life cycle and may delay product marketing for a considerable period of time, limit product marketing, or prevent marketing altogether. Success in pre-clinical or early stage clinical trials does not assure success in later stage clinical trials. Data obtained from pre-clinical and clinical activities is not always conclusive and may be susceptible to varying interpretations that could delay, limit, or prevent marketing approval. Even if a product receives marketing approval, the approval is limited to specific clinical indications. Further, even after marketing approval is obtained, the discovery of previously unknown problems with a product may result in restrictions on the product or even complete withdrawal of the product from the market.

      After product approval, there are continuing significant regulatory requirements imposed by the FDA, including record-keeping requirements, obligations to report adverse experiences, and restrictions on advertising and promotional activities. Quality control and manufacturing procedures must continue to

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      The FDA’s policies may change, and additional governmental regulations may be enacted that could delay, limit, or prevent regulatory approval of our products or affect our ability to manufacture, market, or distribute our products after approval. Moreover, increased attention to the containment of healthcare costs in the United States and in foreign markets could result in new government regulations that could have a material adverse effect on our business. Our failure to obtain coverage, an adequate level of reimbursement, or acceptable prices for our future products could diminish any revenues we may be able to generate. Our ability to commercialize future products will depend in part on the extent to which coverage and reimbursement for the products will be available from government and health administration authorities, private health insurers, and other third-party payors. European Union and U.S. government and other third-party payors increasingly are attempting to contain healthcare costs by consideration of new laws and regulations limiting both coverage and the level of reimbursement for new drugs. We cannot predict the likelihood, nature or extent of adverse governmental regulation that might arise from future legislative or administrative action, either in the United States or abroad.

      Our activities also may be subject to state laws and regulations that affect our ability to develop and sell our products. We are also subject to numerous federal, state, and local laws relating to such matters as safe working conditions, clinical, laboratory, and manufacturing practices, environmental protection, fire hazard control, and disposal of hazardous or potentially hazardous substances. We may incur significant costs to comply with such laws and regulations now or in the future, and the failure to comply may have a material adverse impact on our business prospects.

	Australian Regulatory Requirements

      The Therapeutic Goods Act 1989, or 1989 Act, sets out the legal requirements for the import, export, manufacture and supply of pharmaceutical products in Australia. The 1989 Act requires that all pharmaceutical products to be imported into, supplied in, or exported from Australia be included in the Australian Register of Therapeutic Goods, or ARTG, unless specifically exempted under the Act.

      In order to ensure that a product can be included in the ARTG, a sponsoring company must make an application to the Therapeutic Goods Administration, or TGA. The application usually consists of a form accompanied by data (based on the European Union requirements) to support the quality, safety and efficacy of the drug. In the case of drugs for important medical conditions the TGA will accept either European or American dossier format in an attempt to expedite the registration process.

      The first phase of evaluation, known as the Application Entry Process, is usually a short period during which an application is assessed on an administrative level to ensure that it complies with the basic guidelines. The TGA must decide within 40 working days whether it will accept the application for evaluation.

      Once an application is accepted for evaluation, aspects of the data provided are allocated to evaluators, who prepare evaluation reports. Following this evaluation, the chemistry and quality control aspects of a product may be referred to a sub-committee of the Australian Drug and Evaluation Committee, or ADEC to review the evaluation reports. The evaluation reports are then sent to the sponsoring company who then has the opportunity to comment on the views expressed within the evaluation report and to submit supplementary data to address any issues raised in the evaluation reports.

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      Once the evaluations are complete, the TGA prepares a summary document on the key issues on which advice will be sought from the ADEC. This summary is sent to the sponsoring company which is able to submit a response to the ADEC dealing with issues raised in the summary and those not previously addressed in the evaluation report. The ADEC provides advice on the quality, risk-benefit, effectiveness and access of the drug and conduct medical and scientific evaluations of the application. The ADEC’s resolutions are provided to the sponsoring company after 5 working days.

      The TGA takes into account the advice of the ADEC in reaching a decision to approve or reject a product. Any approval for registration on the ARTG may have conditions associated with it.

      From the time that the TGA accepts the initial application for evaluation, the TGA must complete the evaluation and make a decision on the registration of the product within 255 working days. The TGA also has a system of priority evaluation for products that meet certain criteria, including where the product is a new chemical entity that it is not otherwise available on the market as an approved product, and is for the treatment of a serious, life-threatening illness for which other therapies are either ineffective or not available.

	European Union Regulatory Requirements

      Outside the United States, our ability to market our products will also be contingent upon receiving marketing authorizations from the appropriate regulatory authorities and compliance with applicable post-approval regulatory requirements. Although the specific requirements and restrictions vary from country to country, as a general matter, foreign regulatory systems include risks similar to those associated with FDA regulation, described above. Under EU regulatory systems, marketing authorizations may be submitted either under a centralized or decentralized procedure. Under the centralized procedure, a single application to the European Medicines Evaluation Agency (EMEA) leads to an approval granted by the European Commission which permits the marketing of the product throughout the EU. We assume that the centralized procedure will apply to our products that are developed by means of a biotechnology process. The decentralized procedure provides for mutual recognition of nationally approved decisions and is used for products that do not qualify under the centralized procedure. Under the decentralized procedure, the holders of a national marketing authorization may submit further applications to the competent authorities of the remaining members states which will then be requested to recognize the original authorization based upon an assessment report prepared by the original authorizing competent authority. The recognition process should take no longer than 90 days, but if one member state makes an objection, which under the legislation can only be based on a possible risk to human health, we have the option to withdraw the application from that country or take the application to arbitration by the Committee for Proprietary Medicinal Products (CPMP) of the EMEA. If a referral for arbitration is made, the procedure is suspended, and in the intervening time, the only EU country in which the product can be marketed will be the country where the original authorization has been granted, even if all the other designated countries are ready to recognize the product. The opinion of the CPMP, which is binding, could support or reject the objection or alternatively could reach a compromise position acceptable to all EU countries concerned. Arbitration can be avoided if the application is withdrawn in the objecting country, but once the application has been referred to arbitration, it cannot be withdrawn. The arbitration procedure may take an additional year before a final decision is reached and may require the delivery of additional data.

      As with FDA approval, we may not be able to secure regulatory approvals in Europe in a timely manner, if at all. Additionally, as in the United States, post-approval regulatory requirements, such as those regarding product manufacture, marketing, or distribution, would apply to any product that is approved in Europe, and failure to comply with such obligations could have a material adverse effect on our ability to successfully commercialize any product.

      There has recently been introduced in Europe new legislation designed to harmonise the regulation of clinical trials across the EU and that legislation is currently being implemented on a country by country basis. In addition, new proposals are under advanced consideration which, if brought into law, will effect substantial and material changes to the regulation of medicinal products in Europe. Accordingly, there is a

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Government Funding

      Novogen received financial support for the phenoxodiol drug program from the Australian government under what is known as the START Program. The START Program is a merit-based program designed to encourage and assist Australian companies to undertake research and development and commercialization through a range of grants and loans. The START Program is administered by the Industry Research and Development, or IR&D Board. The IR&D Board is made up of private sector and academic members with expertise and experience in research and development and commercialization. In 1998, the Australian government agreed to provide A$2.7 million (approximately U.S. $1.8 million) to Novogen enabling it to expedite phenoxodiol into clinical trials, provided that the grant money was matched by an equal expenditure by Novogen. The START grant was awarded after the government’s review of the pertinent research results, the intellectual property driving the program, and the likelihood and potential for commercial success of the drug.

      The terms of the grant require Novogen to obtain the consent of the Australian government to deal with the intellectual property rights which have arisen through the program conducted to date. Novogen has obtained the consent of the Australian government to the grant of the license to us and to the other arrangements between us and Novogen concerning the development and commercialization of phenoxodiol.

      Under the START Program, Novogen must meet certain project development and commercialization obligations. Novogen has met the project development obligations and has received final payment thereon. Novogen believes that it is currently in compliance with its commercialization schedule and that it has fulfilled all of its obligations under the terms of the START Program and expects to continue to do so in the future. For additional information on the consequences to us in the event Novogen fails to comply with its obligations under the START Program, see the “— Intellectual Property” and “Risk Factors” sections of this prospectus.

Employees

      We do not have any employees. Novogen provides us with staff and other financial and administrative services under our services agreement with Novogen.

Facilities

      We do not own or lease any facility. Novogen provides us with space for our corporate headquarters.

Legal Proceedings

      We are not currently a party to any material legal proceedings.

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MANAGEMENT

Directors and Executive Officers

      The following sets forth information for each of our directors and executive officers.

	Dr. Graham Edmund Kelly, PhD, age 58, Chairman, Director

      Dr. Kelly was appointed as our Chairman in April 2001. Dr. Kelly founded Novogen in 1992 and has spent nearly 30 years in medical research involving drug development, immunology, surgery and cancer. Dr. Kelly was a senior research fellow in experimental surgery in the Faculty of Medicine at the University of Sydney from 1972 to 1994. He developed the b-1, 3-glucan and isoflavone intellectual property now owned by the Novogen Group. Dr. Kelly was Executive Chairman of Novogen between 1997 and 2000 and continues to act as project leader for phenoxodiol. Dr. Kelly’s term as one of our directors expires in 2005.

	Christopher Naughton, age 50, President and CEO, Director

      Mr. Naughton has been our President and CEO since our inception in December 2000. He also has been the Managing Director of Novogen since March 1997. Mr. Naughton has degrees in Economics from the Australian National University and in Law from the University of New South Wales. He has completed the Program for Management Development at the Harvard Business School and is admitted to practice as an attorney in New South Wales. After working in merchant banking, he has spent the last 18 years in the pharmaceutical industry including appointments as a Director of Wellcome Australia Limited and in world wide business development with the Wellcome Foundation Limited in the UK. Mr. Naughton’s term as one of our directors expires in 2005.

	Philip Andrew Johnston, age 56, Director

      Mr. Johnston has been one of our directors since April 2001. Mr. Johnston has had more than 25 years’ experience in the pharmaceutical industry. He has been a Non-Executive Director of Novogen since January 1997, and Chairman of Novogen since January 2001. Mr. Johnston spent nine years as an Executive Director of Wellcome Australia Limited from June 1988 to September 1997. He was previously Director of two subsidiary companies of GlaxoWellcome. His responsibilities have encompassed production, distribution, quality assurance and consumer product development and he has been directly involved in the establishment of strategic alliances and joint ventures. Mr. Johnston has completed a number of executive development programs including programs at the University of NSW and the London Business School. Mr. Johnston’s term as one of our directors expires in 2004.

	Professor David Morritz de Kretser, age 64, Director

      Professor de Kretser has been one of our Directors since April 2001. Professor de Kretser has been active in medicine and research for over 30 years, taking on roles including Professor of the Department of Anatomy, Monash University, where he has served as a professor since 1978. Professor de Kretser has been employed by Monash University continuously since 1978. Professor de Kretser has served as the Executive Chair of the Monash Institutes of Health and Associate Dean For Biotechnology Development at Monash University since July 2001 and the Director of the Australian Centre for Excellence in Male Reproductive Health since July 2001. He was the Founding Director of the Monash Institute of Reproduction and Development and remains as the Director of the Centre for Molecular Reproduction and Endocrinology within the institute. He has served on numerous international and national committees dealing with research and has experience on a number of professional editorial boards. He has published over 400 research papers and has been invited to speak at numerous national and international conferences and symposiums on topics such as fertility, andrology and endocrinology. Professor de Kretser’s research

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	Professor Paul John Nestel, age 73, Director

      Professor Nestel has been one of our directors since April 2001. Professor Nestel has been a non-executive Director of Novogen since September 2001. Since January 1995, he has been Senior Principal Research Fellow and Head of the Cardiovascular Nutrition laboratory at the Baker Medial Research Institute, Victoria. Professor Nestel has also been Consultant Physician at the Alfred Hospital, Melbourne since January 1995. He is president of the International Life Sciences Institute (Australasia) and a member of the board of directors of ILSI South East Asia. He was formerly Clinical Professor in Medicine, The Flinders University of South Australia. Professor Nestel is an Officer of the Order of Australia. Professor Nestel’s term as one of our directors expires in 2004.

	Stephen Breckenridge, age 61, Director

      Mr. Breckenridge has been one of our directors since August 2003. Mr. Breckenridge has had over 25 years experience in public practice as a Chartered Accountant in Australia and since 2001, has been Managing Director of Breckenridge Consulting Pty Ltd which provides independent tax and management advice to multi-nationals and SME’s. Until 2001, Mr. Breckenridge was a tax partner for 24 years with KPMG in Sydney where he provided corporate tax advice to a wide cross section of business in Australia and overseas with particular emphasis in more latter years on international transfer pricing. Mr. Breckenridge has also been involved in the pharmaceutical and chemical industries over a long period including serving on several industry association committees and leading industry focus groups within KPMG. Mr. Breckenridge holds a Master of Tax degree from the University of Sydney and is a Fellow of the Institute of Chartered Accountants and the Taxation Institute of Australia. Mr. Breckenridge was appointed to our board of directors on August 1, 2003 and his term as one of our directors expires in 2003.

	David Ross Seaton, age 49, Chief Financial Officer

      Mr. Seaton has been our Chief Financial Officer and Company Secretary since December 2000 and has been the Chief Financial Officer of Novogen since September 1999. He holds a degree in Business Studies as well as a Master of Commerce degree from the University of New South Wales. He has completed management development programs at Northwestern University in Chicago as well as at Duke University and at the London Business School. He has 18 years experience in the pharmaceutical industry. Prior to joining Novogen in 1999 was the Finance Director of GlaxoWellcome Australia Limited from 1995 to 1999.

Corporate Governance

	Board of Directors

      Our board of directors has responsibility for our overall corporate governance and meets regularly throughout the year.

      Four of our six existing board members are also currently directors of Novogen. We are a “controlled corporation” within the meaning given to that term by Nasdaq because Novogen owns more than 50% of our voting power. As a controlled corporation, we are exempt from the requirement that our board be composed of a majority of independent directors.

      The board has established an Audit Committee to oversee our financial matters and a Remuneration Committee to review the performance of executive directors and their remuneration.

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	Audit Committee

      The Audit Committee is responsible for overseeing our financial and accounting activities, including external audits and accounting functions. The Audit Committee meets at least twice each year. The Audit Committee’s responsibilities include the annual appointment of our outside auditors and the review of the scope of audit and non-audit assignments and related fees, the accounting principles we use in financial reporting, internal auditing procedures and the adequacy of our internal control procedures. The members of the Audit Committee are Mr. Breckenridge (chairman), Mr. Johnston and Professor de Kretser, all of whom are independent as defined by applicable Nasdaq and SEC rules. Stephen Breckenridge is an audit committee financial expert as defined by SEC rules.

	Remuneration Committee

      The Remuneration Committee reviews the performance of executive directors and sets their remuneration. The Remuneration Committee also has the power to make recommendations to the full board concerning the allocation of share options to directors and employees. The remuneration and terms of appointment of non-executive directors will be set by our board of directors. The members of the Remuneration Committee are Mr. Johnston, Professor de Kretser and Mr. Breckenridge.

Director and Executive Compensation

	Directors

      Our directors, other than Dr. Kelly and Mr. Naughton, receive directors fees of $A30,000 (approximately US$21,500) per annum from us. Dr. Kelly and Mr. Naughton do not receive any remuneration for performing their duties as our directors.

	Executive Officers

      Our executive officers, Dr. Kelly, Mr. Naughton and Mr. Seaton, are also executive officers of Novogen and do not receive any remuneration directly from us in performing their duties as our executive officers. At the present time, their services are provided to us pursuant to the services agreement with Novogen.

Share Option Plan

      We have adopted a share option plan. As of the date of this prospectus, no options were outstanding under the share option plan and we have no present intention of granting any options under the share option plan. We expect that the board would authorize our remuneration committee to oversee the plan, but no such action has been taken. The following is a summary of the plan.

      The plan provides our directors, employees, employees of our affiliates and certain of our contractors and consultants with the opportunity to participate in our ownership.

      The committee will address participation, the number of options offered and any conditions of exercise. In making these determinations the committee will generally consider the participant’s position and record of service to us and our affiliates and potential contribution to the growth of us and our affiliates. Any other matters tending to indicate the participant’s merit may also be considered.

      Options will be exercisable between two years and five years after grant, unless otherwise determined by the committee appointed by the board. Options granted will be exercisable at a price determined by the committee at the time of issue (and will be subject to adjustment in accordance with the terms of the plan).

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      Other key terms of the plan include:

	•	options will lapse if the participants cease to be engaged by us or our affiliates. The committee will have the discretion to waive this provision;
	•	the terms of the plan also provide for adjustments to the rights of an option holder as a result of a reorganization of our capital or other corporate event. The holder of an option is not permitted to participate in any distributions by us or in any rights or other entitlements issued by us to stockholders in respect of our shares unless the options are exercised prior to the relevant record date; and
	•	all options vest on the occurrence of certain events such as a change of control, as defined in the share option plan.

      The plan also contains standard provisions dealing with matters such as administration of the plan, amendment of the plan and termination or suspension of the plan.

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BENEFICIAL OWNERSHIP OF COMMON STOCK

      None of our directors or executive officers own any shares of our capital stock. The following table sets forth information with respect to the beneficial ownership of our common stock by owners of more than 5% of our common stock as of November 24, 2003. The person named in this table has sole voting and investment power with respect to the shares of common stock shown.

Number of Shares

Percentage of

Beneficially

Shares Beneficially

Percentage of Shares

Name and Address of

Owned Before and

Owned Before this

Beneficially Owned

Beneficial Owner

After this Offering

Offering

After this Offering

Novogen Limited

49,500,000

93.1

%

89.7

%

140 Wicks Road

North Ryde NSW 2113

Australia

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CERTAIN RELATIONSHIPS AND RELATED TRANSACTIONS

      Our agreements with Novogen are each summarized below. Each of these agreements was approved by a majority of our independent directors who did not have an interest in the transaction. We believe that each of our agreements with Novogen are on terms as favorable to us as we could have obtained from unaffiliated third parties. The following description is only a summary of what we believe are the material provisions of the agreements. Copies of the agreements have been filed with the Securities and Exchange Commission as exhibits to the registration statement of which this prospectus forms a part.

The Amended and Restated License Agreement

      Novogen’s subsidiary, Novogen Research Pty Limited, has granted our subsidiary, Marshall Edwards Pty Limited, a world-wide, non-transferable license under its patents and patent applications and in its licensed know-how to conduct clinical trials and commercialize and distribute phenoxodiol products. We and Novogen have each guaranteed the obligations of our respective subsidiaries under this license agreement. See “— Guarantee and Indemnity Agreement.” The license is exclusive until the expiration or lapsing of the last relevant Novogen patents or patent applications in the world, which we expect will be no earlier than August 29, 2017, and thereafter is non-exclusive for the remainder of the term of the agreement. The license grants us the right to make, have made, market, distribute, sell, hire or otherwise dispose of phenoxodiol products in the field (the Field) of prevention, treatment or cure of cancer in humans by pharmaceuticals delivered in all forms except topical applications.

      We are obliged to continue current, and undertake further, clinical trials of phenoxodiol, and are responsible for paying for all materials necessary to conduct clinical trials, must conduct all such trials diligently and professionally, must use reasonable endeavors to design and conduct clinical trials to generate outcomes which are calculated to result in regulatory approval of phenoxodiol products, and must keep proper records of all clinical trials and allow Novogen to inspect those records.

      All intellectual property rights in the medication, trial protocols, results of the clinical trials, case report forms and any other materials used in the conduct of the clinical trials are assigned by us to Novogen and we must not publish the results of clinical trials without the prior written consent of Novogen. Each party must disclose to the other party developments, improvements, enhancements or new know-how in relation to the phenoxodiol product which are made or acquired by either party.

      We may not sub-license, sub-contract, or engage agents without the prior written consent of Novogen. Any proposed sub-contractors and agents must first agree in writing to comply with certain confidentiality obligations and to assign to Novogen all intellectual property rights in the Field created or acquired by them in the course of their engagement.

	Marketing and Commercialization

      We may market and commercialize phenoxodiol products under the license in any manner we think fit, so long as we conduct any marketing and commercialization activities on a commercially reasonable basis in compliance with applicable laws and regulations, comply with reasonable directions given by Novogen, act in a manner which we consider to be most beneficial to the interests of us and Novogen, and otherwise act in good faith to Novogen. All advertising and promotional material must be submitted to Novogen for prior approval.

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	Fees, Charges and Costs

      The following table summarizes our responsibility for fees, charges and costs under the license agreement.

Payee		Fee/Cost		Description
Novogen		License Fees		During the exclusivity period:
				• 2.5% of the net sales of phenoxodiol products (invoice price less trade discounts and returns taken); and
				• 25% of all gross income received by or on behalf of us (or our affiliates other than Novogen) from the assignment, sublicensing or other dealing with our rights under the agreement, which we refer to as commercialization income.
				After the exclusivity period, 1.5% of all net sales of phenoxodiol products on the basis described above.
Novogen		First lump sum license fee		A lump sum license fee of $5 million is payable on the later of November 1, 2002 or the date on which the cumulative total of the funds (debt or equity) received by us or our affiliates other than Novogen and the income derived by us or our affiliates other than Novogen and from sales of phenoxodiol products or commercialization income exceeds $25 million.
Novogen		Second lump sum license Fee		A further lump sum license fee of $5 million is payable on the later of November 1, 2003 or the date on which the cumulative total of the funds (debt or equity) received by us or our affiliates other than Novogen and the income derived by us or our affiliates other than Novogen from sales of phenoxodiol products or commercialization income exceeds $50 million.
Novogen		Annual License Fees		For each calendar year set out below for the duration of the exclusivity period, the annual license fees are:
				• calendar year ending December 31, 2003: $1 million;
				• calendar year ending December 31, 2004: $2 million;
				• calendar year ending December 31, 2005: $4 million; and
				• each calendar year following the year ending December 31, 2005: $8 million,
				less any amount payable to Novogen during that calendar year pursuant to the first lump sum license fee referred to above.
Novogen		Patent Costs		We must reimburse Novogen one half of the costs of filing, prosecution and maintenance of the licensed patent rights.
Novogen		Goods and Service Tax		Any goods and services tax payable on any amounts paid under the agreement.
Various		Withholding Tax		We must pay the amount of any withholding taxes payable in any country and must gross-up any royalties withheld.

      Interest accrues daily on the outstanding balance of all overdue amounts payable to Novogen under the license agreement.

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      Since September 30, 2003, we have received $4,636,000 upon the exercise of 1,159,000 of our outstanding warrants. As a result, it is likely that the first lump sum license fee referred to above will become payable to Novogen upon consummation of this offering.

      For the fiscal year ended June 30, 2003 and the quarter ended September 30, 2003, we have included $500,000 and $246,000, respectively, as a license fee expense in our consolidated statements of operations.

     Termination

      We may terminate the license agreement at any time, by giving three months’ notice to Novogen. We may also terminate the agreement if Novogen commits a breach of any of its material obligations under the agreement, becomes the subject of certain bankruptcy proceedings or is unable to lawfully perform its obligations. Novogen may terminate the agreement if we commit a breach of any of our material obligations under the agreement, become the subject of certain bankruptcy proceedings or are unable to lawfully perform our obligations. Novogen may also terminate the agreement immediately if a change of control, as defined in the license agreement, occurs without the consent of Novogen.

The Amended and Restated Manufacturing License and Supply Agreement

      Our subsidiary, Marshall Edwards Pty Limited has granted to Novogen’s subsidiary, Novogen Laboratories Pty Limited, an exclusive, non-transferable sub-license to manufacture and supply phenoxodiol to us in its primary manufactured form. We and Novogen have each guaranteed the obligations of our respective subsidiaries under this manufacturing license and supply agreement. See “— Guarantee and Indemnity Agreement.” Novogen must not sublicense its rights or engage agents or subcontractors to exercise its rights or perform its obligations under the agreement without our prior written consent.

     Supply of Phenoxodiol

      We provide to Novogen rolling forecasts quarterly of our estimated supply requirements for phenoxodiol, and issue purchase orders for phenoxodiol to Novogen specifying the volume of phenoxodiol required. Novogen must confirm the quantity it is able to supply to fulfill the purchase order within 5 business days of receiving the purchase order. Novogen must then supply the volume of phenoxodiol it agreed to supply, and must otherwise use all reasonable endeavors to fulfill the purchase order. Novogen must manufacture and deliver phenoxodiol to us at a port nominated by us. Title to the phenoxodiol does not pass to us until we have paid the purchase price (as described below) and retention of title arrangements apply. We are not obligated to purchase any minimum amount of phenoxodiol from Novogen.

      We must also provide to Novogen at least one year’s advance written notice of the date on which the phenoxodiol product will be first offered for sale commercially.

      If Novogen materially and persistently fails to supply the amount of phenoxodiol ordered by us by the required date, we may manufacture (or engage a third party, without Novogen’s consent, to manufacture) the amount of the shortfall of phenoxodiol until Novogen demonstrates that it is able to consistently supply phenoxodiol in accordance with our requirements. In this case, Novogen must take all reasonable steps to make available to us or the third party, on commercial terms, the know-how necessary to enable that manufacture to occur.

     Fees and Charges

      The purchase price for phenoxodiol supplied is the total costs to Novogen, plus a mark-up of 50%. The purchase price may be adjusted quarterly by Novogen by reference to the actual costs referred to above for the preceding quarter. If at any time we do not pay any amount due to Novogen, Novogen may

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      For the fiscal year ended June 30, 2003 and the quarter ended September 30, 2003, we have included $165,000 and $207,000, respectively, of expense for the cost of drugs supplied by Novogen in the consolidated statements of operations.

     Manufacturing Developments and Improvements

      Each party must disclose to the other any new developments, improvements and new know-how relating to the manufacture of phenoxodiol which are made or acquired by it during the term of the agreement. All intellectual property rights in developments, improvements and new know-how made or acquired by Novogen are to be assigned to us. We must provide to Novogen such technical information and assistance as Novogen reasonably requests in order to exercise its rights and perform its obligations.

      Each party acknowledges that nothing in the agreement shall have the effect of transferring or assigning to Novogen any right, title or interest in any intellectual property rights in the phenoxodiol products licensed under the agreement.

      Novogen agrees to notify us immediately on becoming aware of any infringement of the intellectual property rights in the licensed products or any claim by a third party that the activities of the parties under the agreement infringe such third party’s intellectual property rights. If required, Novogen agrees to be a party to any proceedings brought by us in relation to any infringement of intellectual property rights in the licensed products and also agrees, at our cost, to provide all reasonable assistance in relation to such proceedings and to execute such documents as we reasonably require.

	Termination

      Either party may terminate the agreement immediately at any time if the other party becomes the subject of certain bankruptcy proceedings, becomes unable to carry out the transactions contemplated by the agreement or breaches its obligations and does not cure such breach within 21 days notice. We may also terminate the agreement immediately if the license agreement expires or is terminated. Novogen may also terminate the agreement immediately if a change of control, as defined in the manufacturing license and supply agreement, occurs without the consent of Novogen.

	Limitation of Liability

      The liability of Novogen for breach of conditions or warranties imposed by statute is limited to the replacement of goods; supply of equivalent goods, repair or replacement value of goods or the resupply or payment for resupply of services.

The Amended and Restated License Option Deed

      Novogen’s subsidiary, Novogen Research Pty Limited, has granted our subsidiary, Marshall Edwards Pty Limited, an exclusive first right to accept and an exclusive last right to match any proposed dealing by Novogen with its intellectual property rights with a third party relating to certain synthetic pharmaceutical compounds (other than phenoxodiol) developed by Novogen or its affiliates.

	Option Compounds

      The rights relate to all synthetic pharmaceutical compounds, known as Option Compounds, delivered or taken in all forms except topical applications (other than phenoxodiol, which is the subject of the

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	Dealings in Option Compounds and Exercise of Rights

      Novogen must not, and must ensure that its affiliates other than us do not, deal, solicit entertain or discuss dealings with any intellectual property rights in the Field or in relation to any Option Compounds without giving us an exclusive first right to accept and an exclusive last right to match any such dealing. If we exercise our first right to accept or last right to match, Novogen must deal with the intellectual properly rights in favor of us on the terms and conditions proposed. We have 15 business days to exercise those rights and, if we fail to do so, Novogen may deal with those intellectual property rights in favor of a third party provided that the terms are no more favorable to that third party than those first offered to us or which we declined to match.

	Protection of Intellectual Property

      Novogen must act in good faith toward us in relation to its obligations under the deed and must ensure that all persons involved in any research or development work in the Field in relation to Option Compounds assign all intellectual property rights relating to the Option Compounds to Novogen. Novogen must also ensure that its affiliates, other than us, do the same. Novogen continues to be solely responsible for the maintenance of any patent rights in the Option Compounds, which it may maintain and enforce at its sole discretion and expense.

	Development Reports

      Novogen must provide to us from time to time and in no event less frequently than every six months development reports relating to the clinical trials and development of Option Compounds, and must notify us immediately of any regulatory approvals granted and assessments made by any government agency.

	Term and Termination

      The term of the deed is sixteen years from the commencement date of the agreement, unless terminated earlier. We may terminate the deed at any time on three month’s notice to Novogen. Either party may terminate the deed immediately at any time if the other party becomes the subject of certain bankruptcy proceedings, becomes unable to carry out the transactions contemplated by the agreement or breaches its obligations and does not cure such breach within 21 days notice.

      Novogen may also terminate the deed immediately if a change of control, as defined in the license option deed, occurs without the consent of Novogen.

The Amended and Restated Services Agreement

      Novogen has agreed to provide a range of services to us, or procure that its subsidiaries provide those services.

      These services include providing general assistance and advice on research and development and commercializing phenoxodiol products and other compounds in which we may acquire intellectual property rights in the future, such as Option Compounds in relation to which we have exercised our rights under the license option deed.

      Novogen’s obligations also include providing, within the agreed budgets described below, our needs with respect to secretarial, marketing, finance, logistics, administrative and managerial support. Novogen also plans, conducts and supervises pre-clinical and clinical trials with phenoxodiol and with other compounds in which we have intellectual property rights. Novogen also provides scientific and technical advice on management of pre-clinical and clinical research programs undertaken by us and manages such

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      Novogen may not sub-contract the provision of any part of the services without our prior written consent.

	Fees for Services

      We pay services fees to Novogen on a monthly basis in accordance with an agreed annual budget. At the beginning of each financial year Novogen prepares a budget estimate for us with respect to the percentage of time spent by Novogen’s employees and consultants in the provision of services to us in the previous financial year and any relevant considerations which are likely to influence the time spent for the following financial year. Each estimate must include the remuneration paid by Novogen to each person expected to provide the services and the percentage of time Novogen expects those persons will spend on our business, the allocated on-costs attributable to each person, a premises rental charge and a charge for asset usage and general overheads. The total estimate is to be the sum of these charges plus a mark-up of 10%. We also pay Novogen’s reasonable out of pocket expenses incurred in providing the services to us. At the end of the fiscal year an adjustment is made to reflect actual costs incurred where they differ from budget.

      For the fiscal year ended June 30, 2003 and the quarter ended September 30, 2003, we have included $1,075,000 and $226,000, respectively, as an expense for services provided by Novogen in the consolidated statements of operations.

	Intellectual Property and Confidentiality

      All intellectual property rights created by Novogen in the performance of the services for or at the request of us are licensed to us. Each party also has obligations to the other party to honor the other’s confidential information.

	Termination

      We may terminate our rights and obligations under the services agreement on three months’ written notice to Novogen. Either we or Novogen may terminate the agreement immediately at any time if the other party becomes the subject of certain bankruptcy proceedings, becomes unable to carry out the transactions contemplated by the agreement, breaches its obligations and does not cure such breach within 21 days notice or if a change of control in the other party occurs. Novogen may also terminate the agreement immediately if a change of control, as defined in the services agreement, occurs without the consent of Novogen.

Guarantee and Indemnity Agreement

      We have guaranteed the payment and performance of the obligations of our subsidiary, Marshall Edwards Pty Limited, to Novogen and its subsidiaries, Novogen Laboratories Pty Limited and Novogen Research Pty Limited, under the license agreement, the manufacturing license and supply agreement and the services agreement. Novogen has guaranteed the performance of the obligations of Novogen Research Pty Limited under the license agreement and the obligations of Novogen Laboratories Pty Limited under the manufacturing license and supply agreement to Marshall Edwards Pty Limited. Each of our and Novogen’s obligations in the guarantee and indemnity agreement are absolute, unconditional and irrevocable.

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	Indemnification

      We and Novogen have each agreed to indemnify the other if either of our respective subsidiaries default in the performance of any obligation under the license agreement, the manufacturing license and supply agreement or the services agreement. The defaulting party must indemnify the other against all losses, liabilities and expenses, including legal expenses on a full indemnity basis, incurred, directly or indirectly, as a result of that default. The party in default must pay the amount of those losses, liabilities and expenses on demand to the non-defaulting party. Furthermore, if Marshall Edwards Pty Limited defaults on its payment obligations, we must pay that money as directed by Novogen.

Termination

      This agreement is a continuing obligation, and remains in full force until all the guaranteed obligations have been irrevocably paid and performed in full.

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DESCRIPTION OF OUR SECURITIES

      The shares of common stock and warrants offered hereby will be sold only in units. Each common stock unit consists of one share of common stock and one warrant to purchase one share of common stock. No common stock units have been issued prior to this offering. There will be no trading market for the common stock units. The shares of common stock and warrants comprising the units will separate immediately upon completion of this offering and prior to any trading of the common stock and warrants.

Description of our Capital Stock

      Our total authorized share capital is 113,100,000 shares consisting of 113,000,000 shares of common stock, $0.00000002 par value per share, and 100,000 shares of preferred stock, $0.01 par value per share. As of the date of this prospectus, 53,191,000 shares of our common stock and no shares of preferred stock are issued and outstanding.

	Common Stock

      The holders of common stock are entitled to one vote per share. In the event of a liquidation, dissolution or winding up of our affairs, holders of the common stock will be entitled to share ratably in all our assets that are remaining after payment of our liabilities and the liquidation preference of any outstanding shares of preferred stock. All outstanding shares of common stock are fully paid and non-assessable. The rights, preferences and privileges of holders of common stock are subject to any series of preferred stock that we have issued or that we may issue in the future. The holders of common stock have no preemptive rights and are not subject to future calls or assessments by us.

	Preferred Stock

      The board has the authority to issue up to 100,000 shares of preferred stock in one or more series and to fix the rights, preferences, privileges and restrictions in respect of that preferred stock, including dividend rights, dividend rates, conversion rights, voting rights, terms of redemption (including sinking fund provisions), redemption prices and liquidation preferences, and the number of shares constituting such series and the designation of any such series, without future vote or action by the stockholders. Therefore, the board without the approval of the stockholders could authorize the issue of preferred stock with voting, conversion and other rights that could affect the voting power, dividend and other rights of the holders of common stock or that could have the effect of delaying, deferring or preventing a change of control. As of the date of this prospectus, we have no plans to issue any preferred stock.

	Transfer Agent

      Our transfer agent is Computershare Investor Services, LLC, Two North La Salle Street, Chicago, Illinois 60602.

Description of our Warrants

	Warrants included in the common stock units

      Each warrant included in the common stock units represents the right to purchase one share of our common stock at an exercise price equal to 120% of the initial public offering price set forth on the cover of this prospectus. The warrants are immediately exercisable and will expire three years after the date they are issued. The expiration date may not be extended without an amendment to the warrant agreement by us and the warrant agent. The number of shares of our common stock to be received upon the exercise of each warrant may be adjusted from time to time upon the occurrence of certain events, including but not limited to the payment of a dividend or other distribution in respect common stock, subdivisions, reclassifications or combinations of our common stock. The securities receivable upon exercise of each

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      We have authorized and reserved for issuance all shares of common stock issuable upon exercise of each warrant.

      Holders of the warrants may only exercise their warrants for the purchase of shares of common stock if a registration statement and current prospectus relating to these shares is then in effect and only if the shares are qualified for sale, or deemed to be exempt from qualification under applicable state securities laws. We are required to use our best efforts to maintain a current prospectus relating to these shares of common stock at all times when the market price of the common stock exceeds the exercise price of the warrants, until the expiration date of the warrants. We cannot assure you that an effective registration statement or current prospectus will be available at the time you desire to exercise your warrants.

      Upon exercise of the warrants included in the units, we will, as soon as reasonably practicable, apply to the Alternative Investment Market of the London Stock Exchange for the admission of the shares of common stock underlying the warrants. Under the rules of the Alternative Investment Market, we must submit an application form in respect of such shares at least three business days before the expected date of admission of the shares of common stock underlying the warrants.

      For the term of the warrants, the holders thereof are given the opportunity to profit from an increase in the per share market price of our common stock, with a resulting dilution in the interest of all other stockholders. So long as the warrants are outstanding, the terms on which we could obtain additional capital may be adversely affected. The holders of the warrants might be expected to exercise them at a time when we would, in all likelihood, be able to obtain additional capital by a new offering of securities on terms more favorable than those provided by the warrants.

	Outstanding Warrants

      As of the date of this prospectus, warrants to purchase an aggregate of 1,355,000 shares of our common stock are outstanding. These warrants were issued in May 2002 and have the same terms and provisions as the warrants included in the units, except that the existing warrants are currently exercisable, have an exercise price of $4.00 per share and expire on November 30, 2003 and, the shares to be issued, upon the exercise of these warrants will be Restricted Securities.

Summary of our Amended and Restated By-Laws and Restated Certificate of Incorporation and certain Provisions of the Delaware General Corporation Law (DGCL)

      The following summary of the terms and provisions of the our certificate of incorporation, by-laws, certain aspects of the DGCL does not purport to be complete. Reference should be made to our certificate of incorporation and our by-laws and to applicable law for the complete description.

	Meetings of Stockholders and Voting

      Our by-laws provide for an annual meeting of stockholders, the date of which is fixed by the board. Meetings of stockholders may be held at such place as may be designated by the board. Stockholders are entitled to inspect our books and records to the extent allowable by Delaware law. Our by-laws provide that a quorum for the transaction of business at any meeting of stockholders is stockholders holding at least one-third of the shares entitled to vote at such meeting. Decisions at stockholder meetings will normally be made by a majority of votes cast except in the case of any resolution that, as a matter of law, requires a special majority. Each stockholder entitled to vote at a meeting of stockholders or to express consent or dissent to each corporate action in writing without a meeting may authorize another person or persons to act for him or her by proxy.

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	Appointment and Removal of Directors

      Our certificate of incorporation and by-laws provide that the number of directors will be set by resolution of the board, but shall be between two and nine. We currently have six directors.

      Under our certificate of incorporation and by-laws, directors are to be appointed at the annual general meeting for a term of three years unless the director is removed, retires or the office is vacated earlier. Our board is divided into three classes with respect to the term of office, with the terms of office of one class expiring each successive year. This classified board provision could discourage a third party from making a tender offer for our shares or attempting to obtain control of our company. It could also delay stockholders who do not agree with the policies of the board of directors from removing a majority of the board of directors for two years.

      A director may resign at any time. The resignation is effective on our receipt of notice. Any or all directors may be removed with or without cause by a resolution of stockholders entitled to vote to elect directors. Vacancies may be filled by resolution of a majority of directors then in office or by a sole remaining director, and any director so appointed shall serve for the remainder of the full term of the class of directors in which the vacancy occurred.

	Blank Check Preferred Stock

      Our certificate of incorporation provides our board of directors with the authority, without any further vote or action by our stockholders, to issue shares of preferred stock with terms and preferences determined by our board. Our board of directors may issue shares of preferred stock on terms calculated to discourage, delay or prevent a change of control of our company or the removal of our management.

	Amendments of the By-Laws

      Our by-laws provide that the power to amend the by-laws will vest in the directors, subject to the reserved power of the stockholders to amend or repeal any by-laws adopted by the board.

	Amendments of the Certificate of Incorporation

      Our certificate of incorporation can be amended, after the approval and recommendation of the amendment by the board of directors, by a majority vote of our stockholders, except for certain matters submitted to the board for which the certificate of incorporation requires a vote of not less than eighty percent (80%) of the outstanding shares eligible to be cast and certain other matters for which Delaware law requires a supermajority vote.

	Indemnification of Directors and Officers

      Our certificate of incorporation provides that we will indemnify our directors and officers to the fullest extent permitted by the DGCL. Section 145 of the DGCL provides that the extent to which a corporation may indemnify its directors and officers depends on the nature of the action giving rise to the indemnification right. In actions not on behalf of the corporation, directors and officers may be indemnified for acts taken in good faith and in a manner reasonably believed to be in or not opposed to the best interests of the corporation. In actions on behalf of the corporation, directors and officers may be indemnified for acts taken in good faith and in a manner reasonably believed to be in or not opposed to the best interests of the corporation, except for acts as to which the director or officer is adjudged liable to the corporation, unless the relevant court determines that indemnification is appropriate despite such liability. Section 145 also permits a corporation to (i) reimburse present or former directors or officers for their defense expenses to the extent they are successful on the merits or otherwise and (ii) advance defense expenses upon receipt of an undertaking to repay the corporation if it is determined that payment of such expenses is unwarranted.

      To supplement the general indemnification right contained in our certificate of incorporation, the by-laws provide for the specific indemnification rights permitted by Section 145 (as described above). The by-

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      In addition to the indemnification rights described above, our certificate of incorporation eliminates any monetary liability of directors to us or our stockholders for breaches of fiduciary duty except for (i) breaches of the duty of loyalty, (ii) acts or omissions in bad faith, (iii) improper dividends or share redemptions and (iv) transactions from which the director derives an improper personal benefit.

	Indemnification of Novogen

      Our certificate of incorporation provides that we will indemnify Novogen to the fullest extent permitted by the DGCL in connection with certain actions brought against Novogen by us, any of our stockholders or any other person.

     Transactions and Corporate Opportunities

      Under our certificate of incorporation, we are subject to certain provisions which serve to define and delineate the respective rights and duties of us, Novogen and some of our directors and officers in situations where:

	•	Novogen invests or engages in business activities that are the same as, or similar to, our business activities,
	•	directors, officers and/or employees of Novogen serve as our directors and/or officers, and
	•	Novogen has interest in a potential transaction or matter in which we have a similar interest in exploiting as a matter of corporate opportunity.

      Pursuant to our certificate of incorporation, Novogen has no duty to refrain from investing or engaging in activities or lines of business similar to ours and neither Novogen nor any of its officers, directors, stockholders, affiliates, subsidiaries or employees will be liable to us or our stockholders for breach of any fiduciary duty by reason of any of these activities. In addition, if Novogen acquires knowledge of a potential transaction or matter which may be a corporate opportunity for both our company and Novogen, then neither Novogen nor any of its officers, directors, stockholders, affiliates, subsidiaries or employees will have a duty to communicate or offer this corporate opportunity to us and will not be liable to us or our stockholders for breach of any fiduciary duty as a stockholder by reason of the fact that Novogen or any other such person pursues or acquires the corporate opportunity for itself, directs the corporate opportunity to another person or does not communicate information regarding the corporate opportunity to us.

      We do not release from potential liability our own officers and directors in instances where a corporate opportunity is offered to the officer and/or director in his or her capacity as an officer and that person:

	•	serves as a director, officer or employee of Novogen while holding the position of a director but not officer of our company; or
	•	serves as an officer or employee of Novogen and serves as one of our officers.

      Further, any of our officers who is also a Novogen director but not a Novogen officer or employee may be potentially liable for exploiting our corporate opportunities whether or not such opportunities were offered to that officer in his or her official capacity.

      By becoming one of our stockholders, you will be deemed to have notice of and consented to these provisions of our certificate of incorporation. Until Novogen ceases to beneficially own common stock representing at least 20% of the voting power of our outstanding capital stock, these provisions may not be amended or repealed.

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SHARES ELIGIBLE FOR FUTURE SALE

      Upon completion of this offering, there will be 55,191,000 shares (55,491,000 shares if the underwriter exercises its over-allotment option in full) of our common stock outstanding not including the 2,000,000 shares of common stock underlying the warrants offered hereby and 1,355,000 shares issuable under previously issued warrants. Of the shares which will be outstanding after the offering:

	•	all 2,000,000 shares (2,300,000 shares if the underwriter exercises its over-allotment option in full) included in the common stock units and sold in this offering will be freely tradeable;
	•	3,691,000 shares will be “restricted securities” held by non-affiliates; and
	•	49,500,000 shares will be held by Novogen.

      The restricted securities described above, of which 2,523,000 were issued in May 2002, and of which 1,168,000 were issued upon exercise of outstanding warrants, will be eligible for sale in the public market 90 days after the date of this prospectus, subject to volume limitations, manner of sale provisions and other requirements of Rule 144, from time to time. We also have outstanding warrants to purchase an aggregate of 1,355,000 shares of our common stock. These warrants have an exercise price of $4.00 per share and expire on November 30, 2003. Any shares of our common stock issued upon exercise of these warrants will also be restricted securities.

      In general, under Rule 144 as currently in effect, a person who has beneficially owned restricted securities for at least one year, including an affiliate, is entitled to sell, within any three-month period, a number of shares that does not exceed the greater of:

	•	one percent of the then outstanding shares of our common stock (approximately 551,910 shares immediately following this offering); or
	•	the average weekly trading volume during the four calendar weeks preceding filing of notice of such sale.

      A person (or persons whose shares are aggregated) who is not deemed to have been an affiliate of ours at any time during the 90 days preceding a sale and who owns shares that were acquired from us or an affiliate of ours for at least two years prior to the proposed sale is entitled to sell such shares pursuant to Rule 144(k) without regard to the volume limitations, manner of sale provisions or other limitations of Rule 144.

      Shares held by Novogen may be sold in the public market, subject to the volume, manner of sale and other limitations of Rule 144, but may not be sold in reliance upon Rule 144(k).

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PLAN OF DISTRIBUTION

      Of the common stock units offered by this prospectus, 500,000 units are being offered by means of an underwritten public offering and 1,500,000 units are being offered by means of a directed share subscription program to U.S. holders of ordinary shares and American Depositary Receipts of Novogen and to our U.S. stockholders. The closing of the directed share subscription program and the underwritten offering are not conditioned upon one another and will occur concurrently.

Underwritten Public Offering

      Subject to the terms and conditions of an underwriting agreement entered into between us and Janney Montgomery Scott LLC, as underwriter, the underwriter has agreed to purchase, and we have agreed to sell to the underwriter, 500,000 common stock units (excluding up to 300,000 units that the underwriter has the option to purchase to cover over-allotments, if any), as well as any common stock units that are not subscribed for as part of the directed share subscription program.

      The underwriting agreement provides that the obligations of the underwriter are subject to various conditions, including approval of certain legal matters by its counsel. The nature of the underwriter’s obligations is that the underwriter is committed to purchase and pay for on a firm commitment basis 500,000 common stock units and any of the 1,500,000 units that are not subscribed for in the directed share subscription program. As a result, in the event the underwriter purchases the 500,000 common stock units to be sold on a firm commitment basis, the underwriter also will be obligated to purchase any and all common stock units not purchased in the directed share subscription program.

      The following table shows the per common stock unit and total underwriting discounts and commissions we will pay to the underwriter. These amounts are shown assuming both no exercise and full exercise of the over-allotment option to purchase additional common stock units as part of the underwritten offering.

		Without				With
		Over-Allotment Exercise				Over-Allotment Exercise
Per Common Stock Unit		$				$
Total		$				$

      The underwriter proposes to offer the common stock units directly to the public at the public offering price listed on the cover page of this prospectus. After this offering, the underwriter may change the offering price to the public.

      We have granted to the underwriter an option to purchase additional common stock units representing up to 15% of the units purchased by the underwriter in the underwritten offering, which may be up to an aggregate of 300,000 additional common stock units, at the public offering price, less underwriting discounts and commissions listed on the cover page of this prospectus, solely to cover over-allotments, if any.

      This offering of common stock units is made for delivery when, as and if accepted by the underwriter and subject to prior sale to withdrawal, cancellation or modification of the offering without notice. The underwriter or we reserve the right to reject any order or subscription for the purchase of units in whole or in part.

      We have agreed to indemnify the underwriter against liabilities, including liabilities to which the underwriter may become subject under any applicable federal or state law or otherwise, and to continue to reimburse payments the underwriter may be required to make with respect to these liabilities.

      In addition, the underwriting agreement also provides that, for a period of 120 days from the date of the underwriting agreement, we will not issue or make a disposition of common stock or any securities convertible into or exercisable or exchangeable for common stock without the prior written consent of the underwriter, other than in connection with the exercise of outstanding options and warrants and the grant of options.

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      In order to facilitate this offering, the underwriter may engage in transactions that stabilize, maintain or otherwise affect this offering. Specifically, the underwriter may over-allot or otherwise create a short position in the shares or warrants for its own account by selling more shares and warrants than we have actually sold to it. The underwriter may elect to cover any short position by purchasing shares or warrants in the open market or by exercising the over-allotment option granted to it. In addition, the underwriter may stabilize or maintain the price of the shares or warrants by bidding for or purchasing shares or warrants in the open market. The effect of these transactions may be to stabilize or maintain the market price at a level above which might otherwise prevail in the open market. Neither we nor the underwriter makes any representation or prediction as to the direction or magnitude of any effect that such transactions may have on the price of our common stock. In addition, neither we nor the underwriter makes any representation that the underwriter will engage in such transactions or that such transactions, once commenced, will not be discontinued without notice.

Directed Share Subscription Program

      Of the 2,000,000 common stock units being offered pursuant to this prospectus, we are offering up to an aggregate of 1,500,000 units at the public offering price to U.S. holders of ordinary shares and American Despositary Receipts of Novogen, who beneficially owned their shares or receipts as of the close of business on October 20, 2003, and to our U.S. stockholders who beneficially owned their shares as of the close of business on October 20, 2003. Janney Montgomery Scott LLC will act as our dealer manager in connection with our directed share subscription program. The common stock units being offered under our directed share subscription program are being offered concurrently with the common stock units to be sold in the underwritten offering.

      Up to an aggregate of 1,500,000 common stock units may be purchased under our directed share subscription program and subscribers are required to purchase in round lot increments of 100 common stock units. There is no maximum, however, on the number of units that any one eligible holder may subscribe for under the directed share subscription program. If there are not enough of our units available to fully satisfy all of the subscription requests, we will allocate the available units among eligible holders in our discretion with every subscriber being allocated at least 100 common stock units.

      Janney Montgomery Scott LLC has agreed to purchase any units allocated to the directed share subscription program to the extent that such units are not purchased by the eligible holders under the directed share subscription program.

      In the event that there are closings under the directed share subscription program and in the underwritten offering, these closings will take place concurrently and are not dependent upon one another. We can terminate the directed share subscription program at any time prior to the closing, but are not obligated to terminate the directed share subscription program in the event the underwritten offering is terminated. As a result, if you subscribe for common stock units under the directed share subscription program, you may be obligated to purchase units even if the underwriter does not purchase any units in the underwritten offering. In addition, unless we terminate the directed share subscription program, you will be obligated to purchase units even if you are the only subscriber in the directed share subscription program.

      The purchase price for the units under the directed share subscription program will be the same price per unit as that offered to the public and set forth on the cover page of this prospectus. Janney Montgomery Scott LLC, as dealer manager, will receive a percentage selling fee, as dealer manager, on all units offered through the directed share subscription program. The selling fee represents compensation for the dealer manager’s role as it relates to due diligence, participation in the drafting of this prospectus and general coordination of the overall offering. The shares sold under the directed share subscription program will not be subject to any lock-up agreements.

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      The following table shows the per common stock unit and total selling fees to be paid by us to the dealer manager. These amounts are shown assuming that the direct share subscription program is fully subscribed.

		Directed Share
		Subscription Program
Per Common Stock Unit		$
Total		$

      The expenses of the directed share subscription program, exclusive of the selling fee to be paid to the dealer manager, are estimated to be $               and are payable by us.

      We estimate that the total expenses of this offering, including both the underwritten public offering and the directed share subscription program, but excluding the underwriting discount and selling fees, will be approximately $                    (or $                    if the underwriter exercises its over-allotment option in full), which includes a $                     non-accountable expense allowance payable to the underwriter for costs and expenses (including price stabilization) associated with this offering.

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LEGAL MATTERS

      The validity of the securities offered hereby will be passed upon for us by Morgan, Lewis & Bockius LLP. Certain legal matters will be passed upon for the underwriter by Pepper Hamilton LLP.

EXPERTS

      The consolidated financial statements of Marshall Edwards, Inc. (a development stage company) at June 30, 2003 and 2002, and for the years then ended and for the period from December 1, 2000 (inception) through June 30, 2003, appearing in this prospectus and registration statement have been audited by Ernst & Young LLP, independent auditors, and the information under the caption “Summary Historical Consolidated Financial Data” for each of the two years in the period ended June 30, 2003 and for the period from December 1, 2000 (inception) through June 30, 2003, appearing in this prospectus and registration statement have been derived from consolidated financial statements audited by Ernst & Young LLP, as set forth in their report thereon appearing elsewhere herein.

      Such consolidated financial statements and summary historical consolidated financial data are included in reliance upon such reports given on the authority of such firm as experts in accounting and auditing.

AVAILABLE INFORMATION

      We have filed with the SEC a registration statement on Form S-1 with respect to the common stock units offered hereby. This prospectus, which constitutes a part of the registration statement, does not contain all of the information set forth in the registration statement or the exhibits and schedules which are part of the registration statement. We do not intend to use any forms of prospectus other than printed prospectuses. For further information with respect to us and our common stock and the attached rights, reference is made to the registration statement and the exhibits and schedules thereto. You may read and copy any document we or Novogen periodically file at the SEC’s public reference room in Washington, D.C. Please call the SEC at 1-800-SEC-0330 for further information on the public reference room. These SEC filings are also available to the public from the SEC’s website at http://www.sec.gov.

      Upon completion of this offering, we will become subject to the information and periodic reporting requirements of the Securities Exchange Act and, in accordance therewith, will file periodic reports, proxy statements and other information with the SEC. Such periodic reports, proxy statements and other information will be available for inspection and copying at the SEC’s public reference rooms and the website of the SEC referred to above.

      We are required by the Alternative Investment Market of the London Stock Exchange to prepare half-yearly reports and annual audited accounts. You may request a copy of these reports, which we will provide to you at no cost, by writing or calling us at our mailing address and telephone number: 140 Wicks Road, North Ryde NSW 2113, Australia, telephone: (011) 61 2 8877 6196.

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GLOSSARY OF TERMS

“Androgens”		male sex hormones, e.g. testosterone
“Anti-androgen”		a process that reduces the biological impact of androgens, either by blocking the production of androgens or by interfering with their function
“Apoptosis”		the process of programmed cell death by which a cell dies naturally
“Bioavailable”		absorbed into the body in a useable form
“Bolus injection”		an intravenous injection delivered quickly (usually over several minutes)
“Cytostatic”		the process by which a cell is prevented from dividing
“Cytotoxic”		having a lethal effect on cells
“Death receptor”		signaling molecule that when activated causes cell death
“in vitro”		in the laboratory
“in vivo”		in animals
“IND”		Investigational New Drug application
“Isoflavonoid ring structure”		a chemical term referring to a simple phenolic ring structure
“Kinases”		enzymes that catalyze phosphorylation of acceptor molecules
“MSTR”		Multiple Signal Transduction Regulator or Multiple Signal Transduction Regulation
“NDA”		New Drug Application
“Pharmacokinetic”		the behavior of a drug within the body, in particular the length of time it remains within the blood and the rate at which it is eliminated from the body
“Phase I”		generally the first trial of a drug in humans which tests for safety and dosage tolerance
“Phase II”		clinical trials which test for efficacy and adverse effects of a drug
“Phase III”		usually a multi-center study measuring efficacy in large numbers of patients
“Plasma”		the liquid component of blood
“Prostate cancer”		cancer of the prostate gland
“Prostate smooth muscle cells”		the main type of stromal cells found in the prostate gland
“Prostate stromal cells”		the principal type of non-glandular cells found in the prostate gland
“Signal transduction process”		a series of chemical signals transmitted within cells that lead to the expression of a particular function by the cell
“Sphingosine kinase”		a kinase believed to respond to important signals related to cell survival and cell growth

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INDEX TO CONSOLIDATED FINANCIAL STATEMENTS

Report of Independent Auditors			F-2
Consolidated Balance Sheets as of September 30, 2003 (unaudited), June 30, 2003 and 2002			F-3
Consolidated Statements of Operations for the quarters ended September 30, 2003 and 2002 (unaudited) and the years ended June 30, 2003 and 2002, and the period from December 1, 2000 (inception) through September 30, 2003 (unaudited)			F-4
Consolidated Statements of Stockholders’ Equity			F-5
Consolidated Statements of Cash Flows for the quarters ended September 30, 2003 and 2002 (unaudited) and the years ended June 30, 2003 and 2002, and the period from December 1, 2000 (inception) through September 30, 2003 (unaudited)			F-6
Notes to Consolidated Financial Statements			F-7

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REPORT OF INDEPENDENT AUDITORS

The Board of Directors

      We have audited the accompanying consolidated balance sheets of Marshall Edwards, Inc. (a development stage company) as of June 30, 2003 and 2002, and the related consolidated statements of operations, shareholders’ equity, and cash flows for the years then ended and for the period from December 1, 2000 (inception) through June 30, 2003. These financial statements are the responsibility of the Company’s management. Our responsibility is to express an opinion on these financial statements based on our audits.

      We conducted our audits in accordance with auditing standards generally accepted in the United States. Those standards require that we plan and perform the audit to obtain reasonable assurance about whether the consolidated financial statements are free of material misstatement. An audit includes examining, on a test basis, evidence supporting the amounts and disclosures in the financial statements. An audit also includes assessing the accounting principles used and significant estimates made by management, as well as evaluating the overall financial statement presentation. We believe that our audits provide a reasonable basis for our opinion.

      In our opinion, the financial statements referred to above present fairly, in all material respects, the consolidated financial position of Marshall Edwards, Inc. at June 30, 2003 and 2002, and the consolidated results of its operations and its cash flows for the years then ended and the period from December 1, 2000 (inception) through June 30, 2003, in conformity with accounting principles generally accepted in the United States.

	Ernst & Young LLP

Stamford, CT

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MARSHALL EDWARDS, INC.

CONSOLIDATED BALANCE SHEETS

				September 30,				June 30,
				2003				2003				2002
				(unaudited)
				(In thousands)
ASSETS
Current assets:
	Cash and cash equivalents			$	6,375			$	7,244			$	9,164
	Prepaid expenses and other current assets				192				42				21
		Total current assets			6,567				7,286				9,185
		Total assets		$	6,567			$	7,286			$	9,185
LIABILITIES AND STOCKHOLDERS’ EQUITY
Current liabilities:
	Accounts payable			$	453			$	433			$	198
	Accrued expenses				372				278				—
	Amounts due to parent company				904				642				88
		Total current liabilities			1,729				1,353				286
Stockholders’ equity:
	Preferred stock, $0.01 par value, authorized 100,000 shares, none outstanding				—				—				—
	Common stock, $0.00000002 par value, 113,000,000 authorized shares; 52,032,000 and 52,023,000 issued and outstanding shares in 2003 in 2002, respectively				—				—				—
	Additional paid-in capital				9,058				9,058				9,022
	Deficit accumulated during development stage				(4,270	)			(3,156	)			(123	)
	Accumulated other comprehensive income				50				31				—
		Total stockholders’ equity			4,838				5,933				8,899
		Total liabilities and stockholders’ equity		$	6,567			$	7,286			$	9,185

See accompanying notes.

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MARSHALL EDWARDS, INC

CONSOLIDATED STATEMENTS OF OPERATIONS

																				Period from
																				December 1, 2000
																				(Inception)
																				through
				Quarter Ended September 30,								Year Ended June 30,								September 30,
																				2003
				2003				2002				2003				2002				(unaudited)
				(unaudited)
				(In thousands, except share and per share data)
Revenues:
	Interest and other income			$	21			$	43			$	145			$	7			$	173
		Total revenues			21				43				145				7				173
Operating expenses:
	Research and development				(782	)			(334	)			(2,024	)			(69	)			(2,875	)
	License fees				(246	)			—				(500	)			—				(746	)
	Selling, general and administrative				(107	)			(220	)			(654	)			(60	)			(821	)
		Total operating expenses			(1,135	)			(554	)			(3,178	)			(129	)			(4,442	)
Loss from operations					(1,114	)			(511	)			(3,033	)			(122	)			(4,269	)
Income tax expense					—				—				—				(1	)			(1	)
Net loss arising during development stage				$	(1,114	)		$	(511	)		$	(3,033	)		$	(123	)		$	(4,270	)
Net loss per common share:
	Basic and diluted			$	(0.02	)		$	(0.01	)		$	(0.06	)		$	(0.00	)
Weighted average common shares outstanding					52,032,000				52,023,000				52,023,247				49,769,581

See accompanying notes.

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MARSHALL EDWARDS, INC.

CONSOLIDATED STATEMENTS OF STOCKHOLDERS’ EQUITY

											Deficit
											Accumulated				Accumulated
											During				Other
			Common				Additional				Development				Comprehensive
			Stock				Paid-in Capital				Stage				Income				Total
			(Shares)
							(In thousands)
Balance at June 30, 2001				49,500,000			$	—			$	—			$	—			$	—
Net loss arising during development stage												(123	)							(123	)
Common stock issued May 22, 2002 (including 2,523,000 warrants)				2,523,000				9,022												9,022
Balance at June 30, 2002				52,023,000				9,022				(123	)			—				8,899
Net loss arising during development stage												(3,033	)							(3,033	)
Foreign currency translation adjustments																31				31
	Comprehensive loss																			(3,002	)
Common stock issued, June 26, 2003				9,000				36												36
Balance at June 30, 2003				52,032,000				9,058				(3,156	)			31				5,933
Net loss arising during development stage (unaudited)												(1,114	)							(1,114	)
Foreign currency translation adjustments (unaudited)																19				19
Comprehensive loss (unaudited)																				(1,095	)
Balance at September 30, 2003 (unaudited)				52,032,000			$	9,058			$	(4,270	)		$	50			$	4,838

See accompanying notes.

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MARSHALL EDWARDS, INC.

CONSOLIDATED STATEMENTS OF CASH FLOWS

				Quarter Ended																Period from
				September 30,								Year Ended June 30,								December 1, 2000
																				(Inception) through
				2003				2002				2003				2002				September 30, 2003
																				(unaudited)
				(unaudited)
				(In thousands)
Operating activities:
	Net loss arising during development stage				(1,114	)			(511	)		$	(3,033	)		$	(123	)		$	(4,270	)
	Adjustments to reconcile net loss to cash (used in) provided by operating activities:
	Changes in operating assets and liabilities:
		Prepaid expenses and other current assets			24				5				(21	)			(21	)			(18	)
		Accounts payable			20				(147	)			381				52				453
		Accrued expenses			56				—				278				—				334
		Amounts due to parent company			262				64				554				88				904
	Net cash (used in) provided by operating activities				(752	)			(589	)			(1,841	)			(4	)			(2,597	)
Financing activities:
	Net proceeds from issuance of Common Stock				—				—				36				9,022				9,058
	Costs in connection with issuance of Common Stock				(174	)			—				—				—				(174	)
	Amounts payable in connection with issuance of Common Stock				38				—				(146	)			146				38
	Net cash (used in) provided by financing activities				(136	)			—				(110	)			9,168				8,922
	Effect of exchange rate changes on cash and cash equivalents				19				—				31				—				50
	Net (decrease) increase in cash and cash equivalents				(869	)			(589	)			(1,920	)			9,164				6,375
	Cash and cash equivalents at beginning of period				7,244				9,164				9,164				—				—
	Cash and cash equivalents at end of period			$	6,375			$	8,575			$	7,244			$	9,164			$	6,375
	Income taxes paid			$	—			$	—			$	—			$	1			$	1

See accompanying notes.

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MARSHALL EDWARDS, INC.

NOTES TO CONSOLIDATED FINANCIAL STATEMENTS

June 30, 2003

(Information pertaining to the three months ended September 30, 2003 and 2002, and the information pertaining to the period from December 1, 2000 (inception) through September 30, 2003 is unaudited)

1.	Organization and Basis of Preparation of Financial Statements

      Marshall Edwards, Inc. (the “Company” or “MEI”) is a development stage company incorporated in December 2000 that commenced operations in May 2002 coinciding with its listing on the London Stock Exchange’s Alternative Investment Market (AIM). In connection with its listing, 2,523,000 shares of Common Stock and 2,523,000 warrants, exercisable prior to November 30, 2003 at an exercise price of $4.00 per share (9,000 exercised on June 26, 2003), were issued in May 2002 at $4.00 per share. Total proceeds of $9,022,000 were received net of $1,070,000 of transaction costs. Following the listing, Novogen Limited, an Australian pharmaceutical company listed on both the Australian Stock Exchange and NASDAQ, retained 95.1% of the Company’s Common Stock. The costs of organizing MEI were paid by Novogen and were minimal.

      The Company, including its Australian subsidiary, Marshall Edwards Pty. Limited (“MEPL”) (together, the “MEI Group”) is a pharmaceutical company with a primary focus on the development and commercialization of drugs for the treatment of cancer. The Company is presently engaged in the clinical development and commercialization of a drug candidate called phenoxodiol. The Company plans to develop phenoxodiol for use in a wide range of human cancers. The Company operates primarily in Australia and the United States.

      Novogen Limited and its subsidiary companies, other than MEI Group (“Novogen”), has granted to the MEI Group an exclusive license under its patent applications and the intellectual property rights in the relevant know-how to develop, market and distribute all forms of administering phenoxodiol for anti-cancer uses except topical applications. In addition, the MEI Group has the option of an exclusive first right and an exclusive last right to match any proposal dealing with third parties by Novogen Research Pty Ltd for the intellectual property rights and development of synthetic pharmaceutical compounds delivered or taken in all forms except topical applications (other than phenoxodiol, which is the subject of a license agreement between the Company and Novogen), developed by or on behalf of Novogen or its affiliates, which have known applications in the field of prevention, treatment or cure of cancer in humans.

      The MEI Group’s initial business focus is to continue the clinical program currently underway for the development and commercialization of phenoxodiol.

2.	Accounting Policies

	Revenue Recognition

	Interest

      The only revenue earned to date is interest on cash and cash equivalents.

	Principles of Consolidation

      The consolidated financial statements include the accounts of Marshall Edwards, Inc. and its subsidiary, Marshall Edwards Pty. Limited which is a wholly-owned Australian company. Significant intercompany accounts and transactions have been eliminated in consolidation.

	Estimates

      The preparation of the consolidated financial statements in conformity with accounting principles generally accepted in the United States requires management to make estimates and assumptions that affect the amounts reported in the consolidated financial statements and the accompanying notes. Actual results could differ from those estimates.

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NOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued)

	Cash Equivalents

      The Company considers all highly liquid investments with a maturity of three months or less when purchased to be cash equivalents.

	Income Taxes

      Income taxes have been provided for using the liability method in accordance with FASB Statement No. 109, “Accounting for Income Taxes.” Under this method, deferred tax assets and liabilities are recognized and measured using enacted tax rates in effect for the year in which the differences are expected to be recognized. Valuation allowances are established against the recorded deferred income tax assets to the extent that management believes that it is more likely than not that a portion of the deferred income tax assets are not realizable.

	Fair Value of Financial Instruments

      The carrying amounts of the Company’s financial instruments, including cash and cash equivalents, and accounts payable approximate fair value.

	Foreign Currency Translation

      The financial statements of MEPL have been translated into U.S. dollars in accordance with FASB Statement No. 52, “Foreign Currency Translation.” Assets and liabilities are translated into U.S. dollars using the exchange rates in effect at the balance sheet date. Income statement amounts have been translated using the average exchange rate for the year. Accumulated other comprehensive loss includes the cumulative translation adjustments. Realized gains and losses from foreign currency transactions are reflected in the consolidated statements of operations and were not significant for all periods presented.

	Research and Development Expenses

      Research and development expenses relate primarily to the cost of conducting human clinical trials of phenoxodiol. Research and development costs are charged to expense as incurred. Research and development expenses consist mainly of clinical trial expenditures, payments to Novogen for research and support services under the terms of the amended and restated services agreement and the cost of phenoxodiol used in the clinical trials supplied by Novogen under the terms of the amended and restated manufacturing license and supply agreement.

	License Fees

      Costs incurred related to the acquisition or licensing of products that have not yet received regulatory approval to be marketed, or that are not commercially viable and ready for use or have no alternative future use, are charged to earnings in the period incurred.

	Stock-Based Compensation

      The Company’s share option plan provides for the grant of options to employees of the Company and its affiliates. To date no options have been granted under the plan.

	Basic and Diluted Loss Per Share

      Basic and diluted earnings or loss per share is calculated in accordance with FASB Statement No. 128, “Earnings Per Share.” In computing basic earnings or loss per share, the dilutive effect of stock

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NOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued)

options and warrants are excluded, whereas for diluted earnings per share they are included unless the effect is anti-dilutive.

	Comprehensive Loss

      Comprehensive loss is comprised of net loss and other comprehensive loss. Other comprehensive loss includes certain changes in stockholders’ equity that are excluded from net loss is comprised of changes in foreign currency translation adjustments. Comprehensive loss for all periods presented has been reflected in the consolidated statement of stockholders’ equity.

	Recent Accounting Announcements

      Accounting pronouncements issued by the financial accounting standards board or other authoritative accounting standards groups with future effective dates are either not applicable or not significant to the consolidated financial statements.

3.	Income Taxes

      Loss from operations consists of the following:

		Year Ended June 30,
		2003				2002
		(In thousands)
Domestic		$	(186	)		$	(19	)
Foreign			(2,847	)			(103	)
		$	(3,033	)		$	(122	)

      The reconciliation of income tax computed at the U.S. federal statutory tax rate to income tax expense attributable to loss arising during development stage is as follows:

		Year Ended June 30,
		2003								2002
		(In thousands)				%				(In thousands)				%
Tax at U.S. statutory rates		$	(1,062	)			35			$	(43	)			35
Australian tax			—				—				1				—
Valuation allowance			1,062				(35	)			43				(35	)
		$	—				—			$	1				—

F-9

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NOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued)

      Deferred tax liabilities and assets are comprised of the following:

		June 30,
		2003				2002
		(In thousands)
Deferred tax liabilities
Prepayments		$	—			$	4
Total deferred tax liabilities			—				4
Deferred tax assets
Consultant and other accruals			265				6
Total deferred tax assets			265				6
Valuation allowance for deferred tax assets			(265	)			(2	)
Net deferred tax assets and liabilities		$	—			$	—

      Management evaluates the recoverability of the deferred tax asset and the amount of the required valuation allowance. Due to the uncertainty surrounding the realization of the tax deductions in future tax returns, the Company has recorded a valuation allowance against its net deferred tax asset at June 30, 2003 and 2002. At such time as it is determined that it is more likely than not that the deferred tax assets will be realized, the valuation allowance will be reduced.

      There was no benefit from income taxes recorded for the period from December 1, 2000 (inception) to June 30, 2003 due to the Company’s inability to recognize the benefit of net operating losses. The Company had federal net operating loss carryforwards of approximately $205,000 and $14,000 at June 30, 2003 and 2002, respectively. The federal net operating losses will begin to expire in 2022.

      Foreign income tax losses of approximately $2,039,000 and $103,000 at June 30, 2003 and 2002, respectively, may be carried forward indefinitely.

4.     Loss Per Share

      The following table sets forth the components for the computation of basic and diluted net loss per common share:

		Quarter Ended September 30,								Year Ended June 30,
		2003				2002				2003				2002
		(unaudited)
		(In thousands)
Numerator
Net loss arising during development stage		$	(1,114	)		$	(511	)		$	(3,033	)		$	(123	)
Effect of dilutive securities			—				—				—				—
Numerator for diluted earnings per share		$	(1,114	)		$	(511	)		$	(3,033	)		$	(123	)
Denominator
Denominator for basic earnings per share — weighted average common shares outstanding			52,032,000				52,023,000				52,023,247				49,769,581
Effect of dilutive securities			—				—				—				—
Dilutive potential common shares			52,032,000				52,023,000				52,023,247				49,769,581

F-10

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NOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued)

5.     Financial Instruments

      The fair value of financial assets and liabilities approximates their carrying value in the Consolidated Balance Sheets because they are short term and at market rates of interest.

6.     Commitments and Contingencies

      At June 30, 2003, the Company has contracted to conduct research and development expenditures amounting to approximately $1,249,000. At September 30, 2003, the Company had contracted to conduct research and development expenditures amounting to approximately $1,082,000. Such amounts are expected to be incurred within the next year.

      The Company is not currently a party to any material legal proceedings.

      The Company’s certificate of incorporation provides that it will indemnify Novogen in connection with certain actions brought against Novogen by any of the Company’s stockholders or any other person.

7.     Segment Information

      The Company’s focus is to continue the clinical program currently underway for the development and commercialization of phenoxodiol.

		USA								Australia								Eliminations								Total
		June 30,				June 30,				June 30,				June 30,				June 30,				June 30,				June 30,				June 30,
		2003				2002				2003				2002				2003				2002				2003				2002
		(In thousands)
Interest and other income		$	110			$	5			$	35			$	2			$	—			$	—			$	145			$	7
Total revenues		$	110			$	5			$	35			$	2			$	—			$	—			$	145			$	7
Loss from operations		$	(186	)		$	(19	)		$	(2,847	)		$	(103	)		$	—			$	—			$	(3,033	)		$	(122	)
Income tax expense																										$	—			$	(1	)
Net loss arising during development stage																										$	(3,033	)		$	(123	)
Segment assets		$	8,896			$	9,188			$	374			$	1,981			$	(1,984	)		$	(1,984	)		$	7,286			$	9,185
Segment liabilities		$	43			$	185			$	1,310			$	101			$	—			$	—			$	1,353			$	286

		USA								Australia								Eliminations								Total
		Sept 30,				Sept 30,				Sept 30,				Sept 30,				Sept 30,				Sept 30,				Sept 30,				Sept 30,
		2003				2002				2003				2002				2003				2002				2003				2002
		(In thousands)
		(Unaudited)
Interest and other income			16				32				5				11				—				—				21				43
Total revenues			16				32				5				11				—				—				21				43
Loss from operations			6				29				1,108				482				—				—				1,114				511
Income tax expense																							—				—
Net loss arising during development stage																											1,114				511
Segment assets			8,930				8,996				2,921				1,579				(5,284	)			(1,984	)			6,567				8,591
Segment liabilities			82				22				1,647				181				—				—				1,729				203

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NOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued)

8.     Related Party Transactions

     License Agreement

      The license agreement is an agreement under which Novogen grants to MEPL a worldwide non-transferable license to conduct clinical trials and commercialize and distribute all forms of phenoxodiol except topical applications. The agreement covers uses of phenoxodiol in the field of prevention, treatment or cure of cancer in humans. The license is exclusive until the expiration of the last relevant Novogen patent right in the world (expected no earlier than August 29, 2017) and thereafter is nonexclusive. The Company may terminate the agreement with three months notice. Novogen may terminate the agreement if a change of control, as defined in the license agreement, occurs without the consent of Novogen. Amounts payable to Novogen under terms of the license agreement is as follows:

	(1) A lump sum license fee of $5,000,000 is payable to Novogen on the later of November 1, 2002 or on the date when the cumulative total of all funds received from debt or equity issuances and revenue received from commercialization income, other than sales, and sales of phenoxodiol products exceeds $25,000,000.
	(2) A further lump sum license fee of $5,000,000 is payable to Novogen on the later of November 1, 2003 or on the date when the cumulative total of all funds received from debt or equity issuances and revenue received from commercialization income, other than sales, and sales of phenoxodiol products exceeds $50,000,000.

      In addition to the amounts above, the Company must pay Novogen 2.5% of all net sales and 25% of commercialization income. After the exclusivity period of the license, 1.5% of net sales must be paid to Novogen.

      The cumulative total of funds received by the Company is $10,128,000.

      Amounts payable for annual license fees under the license agreement for the calendar years ended December 31 are as follows:

2003		$	1,000,000
2004		$	2,000,000
2005		$	4,000,000
Each calendar year thereafter		$	8,000,000

      Any amounts payable to Novogen under the above annual payments will be reduced for amounts paid under the first lump sum license fee referred to in (1) above. For the year ended June 30, 2003, $500,000 has been included as license fee expense in the consolidated statements of operations.

      Novogen developed phenoxodiol in part using funds from the Australian government under what is known as the START Program. In the event Novogen fails to comply with its obligations under the agreement which governs this grant, or if Novogen undergoes a change of control, the Australian government has a right to demand that intellectual property created during the course of the project funded by the grant be vested back in the Australian government. The Australian government may then license the intellectual property rights related to phenoxodiol to other parties and may demand other intellectual property rights from Novogen. Any such reclamation by the Australian government could preclude the Company’s use of Novogen’s intellectual property in the development and commercialization of phenoxodiol and the Company may have to compete with other companies to whom the Australian government may license the intellectual property.

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NOTES TO CONSOLIDATED FINANCIAL STATEMENTS — (Continued)

     License Option Deed

      The license option deed grants MEPL an exclusive right to accept and an exclusive right to match any proposed third-party dealing by Novogen of its intellectual property rights in other synthetic compounds that have known or potential anti-cancer applications in all forms other than topical applications.

     Services Agreement

      Neither the Company nor MEPL currently intends to directly employ any staff and Novogen will provide or procure services reasonably required by the MEI Group relating to the development and commercialization of phenoxodiol and for other administrative and managerial support. Novogen will provide these services at cost plus a 10% markup. Cost is based on estimates regarding the percentage of time spent by Novogen employees and consultants, a premises rental charge and a charge for asset usage and general overhead. The Company may terminate the agreement with three months notice. Novogen may terminate the agreement under certain circumstances.

     Manufacturing, License and Supply Agreement

      Under the terms of the Manufacturing License and Supply Agreement, Novogen will supply phenoxodiol in its primary manufactured form for the clinical trial development program and phenoxodiol’s ultimate commercial use. Novogen will supply phenoxodiol at cost plus a 50% markup. The Company or Novogen may terminate the agreement under certain circumstances.

      Transactions amounting to $1,740,000 and $79,600 were made under the license agreement, the Services Agreement and the Manufacturing, License and Supply Agreement with Novogen during the years ended June 30, 2003 and 2002, respectively.

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2,000,000 Common Stock Units

Marshall Edwards, Inc.

Janney Montgomery Scott LLC

                    , 2003

      Through and including                     (the 25th day after the date of this prospectus), all dealers that buy, sell, or trade our common stock units or the shares of common stock and warrants that comprise the common stock units, whether or not participating in this offering, may be required to deliver a prospectus. This delivery requirement is in addition to the dealers’ obligation to deliver a prospectus when acting as underwriters and with respect to their unsold allotments or subscriptions.

      You should rely only on the information contained in this prospectus. We have not authorized anyone to provide you with information different from that contained in this prospectus. The information contained in this prospectus is accurate only as of the date of this prospectus, regardless of the time of delivery of this prospectus or of any distribution of the common stock units or the shares of common stock and warrants that comprise the common stock units.

      No document in connection with this offering, including this prospectus, may be issued or passed on in the United Kingdom to, or is directed at, any person, other than: (i) to persons whose ordinary activities involve them in acquiring, holding, managing or disposing of investments (as principal or agent) for the purposes of their businesses and otherwise in circumstances which will not result in an offer to the public in the United Kingdom within the meaning of the Public Offers of Securities Regulations 1995 (as amended) and in circumstances where Section 21(1) of the Financial Services and Markets Act 2000 does not apply by virtue of such person being an investment professional as that term is defined in Article 19 of the Financial Services and Markets Act 2000 (Financial Promotion) Order 2001; or (ii) to persons to whom the document may otherwise lawfully be issued. Nothing in this prospectus should be construed as investment advice to any person. If you are a recipient of this prospectus outside of the scope of the above criteria then you may not act upon the content of this prospectus.

      We are not making this offering described in this prospectus in Australia or in any state or other jurisdiction in which it is unlawful to do so nor are we selling or accepting any offers to purchase any of our common stock units from persons who are residents of such jurisdictions.

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PART II

INFORMATION NOT REQUIRED IN PROSPECTUS

Item 13.     Other Expenses of Issuance and Distribution.

An estimate of expenses follows:
Securities and Exchange Commission registration fee			$	2,660.81
NASD filing fee				3,789.00
Nasdaq National Market listing fee				105,000.00
Printing and engraving expenses				250,000.00
Transfer agent and registrar fees and expenses				7,500.00
Information agent expenses				10,000.00
Legal fees and expenses				750,000.00
Accountants’ fees and expenses				80,000.00
Blue Sky fees and expenses (including legal fees)				25,000.00
Miscellaneous expenses				41,050.19
	Total		$	1,275,000.00

Item 14.	Indemnification of Directors and Officers.

      Our Restated Certificate of Incorporation provides that we will indemnify our directors and officers to the full extent permitted by the DGCL. Section 145 of the DGCL provides that the extent to which a corporation may indemnify its directors and officers depends on the nature of the action giving rise to the indemnification right. In actions not on behalf of the corporation, directors and officers may be indemnified for acts taken in good faith and in a manner reasonably believed to be in or not opposed to the best interests of the corporation. In actions on behalf of the corporation, directors and officers may be indemnified for acts taken in good faith and in a manner reasonably believed to be in or not opposed to the best interests of the corporation, except for acts as to which the director or officer is adjudged liable to the corporation, unless the relevant court determines that indemnification is appropriate despite such liability. Section 145 also permits a corporation to (i) reimburse present or former directors or officers for their defense expenses to the extent they are successful on the merits or otherwise and (ii) advance defense expenses upon receipt of an undertaking to repay the corporation if it is determined that payment of such expenses is unwarranted.

      To supplement the general indemnification right contained in our Restated Certificate of Incorporation, our Amended and Restated By-Laws provide for the specific indemnification rights permitted by Section 145 (as described above). Our Amended and Restated By-Laws also permit us to purchase Directors and Officers insurance, but no director or officer has a right to require this.

      In addition to the indemnification rights described above, our Restated Certificate of Incorporation eliminates any monetary liability of directors to us or our shareholders for breaches of fiduciary duty except for (i) breaches of the duty of loyalty, (ii) acts or omissions in bad faith, (iii) improper dividends or share redemptions and (iv) transactions from which the director derives an improper personal benefit.

Item 15.	Recent Sales of Unregistered Securities.

      On May 22, 2002, we sold 2,523,000 shares of our common stock for an aggregate of $10.1 million. These shares of common stock were listed on the London Stock Exchange’s Alternative Investment Market. These shares of common stock each had an attaching warrant entitling the holder to purchase one additional share of our common stock. These warrants are exercisable prior to November 30, 2003 and have an exercise price of $4.00 per share. These securities were offered and sold by us to Oppenheimer

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      In June 2003, we issued 9,000 shares of our common stock upon the exercise of 9,000 of the warrants that were issued in May 2002. The shares issued upon exercise of the warrants were issued to KBC Peel Hunt Ltd, a non-U.S. person, in a private placement transaction outside the United States. In November 2003, we issued 1,159,000 shares of our common stock upon the exercise of 1,159,000 of the warrants that were issued in May 2002. 875,000 of the shares issued upon exercise of the warrants were issued to Oppenheimer International Growth Funds, 175,000 of the shares issued upon exercise of the warrants were issued to MEI Phase II LP, 100,000 of the shares issued upon exercise of the warrants were issued to Fosters Stockbroking Nominees Pty Ltd and 9,000 of the shares issued upon exercise of the warrants were issued to Winterflood Securities Ltd, each a non-U.S. person, in private placement transactions outside the United States. No general solicitation was made by either us or any person acting on our behalf; the shares issued upon exercise of the warrants are subject to transfer restrictions; and certificates for the shares contain appropriate legends stating that such securities have not been registered under the Securities Act and may not be offered or sold absent registration or pursuant to an exemption therefrom. No underwriters were involved in the foregoing sales of securities. These transactions were exempt from registration pursuant to Section 4(2) of the Securities Act of 1933 or Regulation S promulgated thereunder.

Item 16.	Exhibits and Financial Statement Schedules.

	(a)	Exhibits.

Exhibit
Number				Exhibit
	1			Form of Underwriting Agreement
	3.1*			Restated Certificate of Incorporation.
	3.2*			Amended and Restated Bylaws.
	4.1*			Specimen Common Stock Certificate.
	4.2*			Warrant Agreement.
	4.3*			Specimen Warrant Certificate.
	5*			Opinion of Morgan, Lewis & Bockius LLP.
	10.1*			Amended and Restated License Agreement between Novogen Research Pty Limited and Marshall Edwards Pty Limited.
	10.2*			Amended and Restated Manufacturing License and Supply Agreement between Novogen Laboratories Pty Limited and Marshall Edwards Pty Limited.
	10.3*			Amended and Restated License Option Deed between Novogen Research Pty Limited and Marshall Edwards Pty Limited.
	10.4*			Amended and Restated Services Agreement among Novogen Limited, Marshall Edwards, Inc. and Marshall Edwards Pty Limited.
	10.5*			Guarantee and Indemnity among Marshall Edwards, Inc., Novogen Laboratories Pty Limited, Novogen Research Pty Limited and Novogen Limited.

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Exhibit
Number				Exhibit
	10.6*			Marshall Edwards, Inc. Share Option Plan.
	10.7*			Form of outstanding Warrant issued to Non-US Persons May 2002.
	10.8*			Form of outstanding Warrant issued to US Persons May 2002.
	21*			Subsidiaries of Marshall Edwards, Inc.
	23.1*			Consent of Morgan, Lewis & Bockius LLP (contained in Exhibit 5).
	23.2			Consent of Ernst & Young LLP.
	24*			Power of Attorney (included on signature page).
	99.1			Form of letter from Marshall Edwards, Inc. to eligible holders of its common stock and to eligible holders of ordinary shares and American Depositary Receipts of Novogen Limited, describing the Directed Share Subscription Program.
	99.2*			Form of letter from Janney Montgomery Scott LLC to eligible holders.
	99.3			Form of brokers letter.
	99.4			Form of subscription agreement.

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*	Previously filed.

      (b) Financial Statement Schedules.

      All financial statement schedules have been omitted because either they are not required, are not applicable, or the information is otherwise set forth in the financial statements and notes thereto.

Item 17.	Undertakings.

      (1) The undersigned registrant hereby undertakes:

	(i) To file, during any period in which offers or sales are being made, a post-effective amendment to this registration statement:

	(a) To include any prospectus required by Section 10(a)(3) of the Securities Act of 1933;
	(b) To reflect in the prospectus any facts or events arising after the effective date of the registration statement (or the most recent post-effective amendment thereof) which, individually or in the aggregate, represent a fundamental change in the information set forth in the registration statement. Notwithstanding the foregoing, any increase or decrease in volume of securities offered (if the total dollar value of securities offered would not exceed that which was registered) and any deviation from the low or high end of the estimated maximum offering range may be reflected in the form of prospectus filed with the Commission pursuant to Rule 424(b) if, in the aggregate, the changes in volume and price represent no more than a 20 percent change in the maximum aggregate offering price set forth in the “Calculation of Registration Fee” table in the effective registration statement;
	(c) To include any material information with respect to the plan of distribution not previously disclosed in the registration statement or any material change to such information in the registration statement.

	(ii) That, for the purpose of determining any liability under the Securities Act of 1933, each such post-effective amendment shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.

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	(iii) To remove from registration by means of a post-effective amendment any of the securities being registered which remain unsold at the termination of the offering.
	(iv) To provide to the underwriters at the closing specified in the Underwriting Agreement share and warrant certificates in such denominations and registered in such names as required by the underwriters to permit prompt delivery to each purchaser.
	(v) That for purposes of determining any liability under the Securities Act, the information omitted from the form of prospectus filed as part of this registration statement in reliance on Rule 430A and contained in a form of prospectus filed by the registrant pursuant to Rule 424(b)(1) or (4) or 497(h) under the Securities Act shall be deemed to be part of this registration statement as of the time it is first declared effective.
	(vi) That for the purpose of determining any liability under the Securities Act of 1933, each post-effective amendment that contains a form of prospectus shall be deemed to be a new registration statement relating to the securities offered therein, and the offering of such securities at that time shall be deemed to be the initial bona fide offering thereof.

      (2) Insofar as indemnification for liabilities arising under the Securities Act of 1933 may be permitted to directors, officers and controlling persons of the registrant pursuant to the provisions described under Item 14 above, or otherwise, the registrant has been advised that in the opinion of the Securities and Exchange Commission such indemnification is against public policy as expressed in the Act and is, therefore, unenforceable. In the event that a claim for indemnification against such liabilities (other than the payment by the registrant of expenses incurred or paid by a director, officer or controlling person of the registrant in the successful defense of any action, suit or proceeding) is asserted by such director, officer or controlling person in connection with the securities being registered, the registrant will, unless in the opinion of its counsel the matter has been settled by controlling precedent, submit to a court of appropriate jurisdiction the question whether such indemnification by it is against public policy as expressed in the Act and will be governed by the final adjudication of such issue.

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SIGNATURES

      Pursuant to the requirements of the Securities Act of 1933, the registrant has duly caused this registration statement to be signed on its behalf by the undersigned, thereunto duly authorized, in Sydney, Australia on November 26, 2003.

	MARSHALL EDWARDS, INC.
	(Registrant)

	By:	/s/ CHRISTOPHER NAUGHTON

	Christopher Naughton
	President and Chief Executive Officer

      Pursuant to the requirements of the Securities Act of 1933, this registration statement has been signed below by the following persons, in the capacities and on the dates indicated.

Signature				Title		Date
/s/ CHRISTOPHER NAUGHTON Christopher Naughton				President and Chief Executive Officer, Director (Principal Executive Officer)		November 26, 2003
/s/ DAVID R. SEATON David R. Seaton				Chief Financial Officer and Secretary (Principal Financial Officer and Principal Accounting Officer)		November 26, 2003
* Dr. Graham E. Kelly				Chairman		November 26, 2003
* Philip A. Johnston				Director		November 26, 2003
* David Morritz de Kretser				Director		November 26, 2003
* Paul J. Nestel				Director		November 26, 2003
* Stephen Breckenridge				Director		November 26, 2003
*By:		/s/ DAVID R. SEATON David R. Seaton Attorney-in-fact

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INDEX TO EXHIBITS

Exhibit
Number				Exhibit
	1			Underwriting Agreement.
	3	.1*		Restated Certificate of Incorporation.
	3	.2*		Amended and Restated Bylaws.
	4	.1*		Specimen Common Stock certificate.
	4	.2*		Warrant Agreement.
	4	.3*		Specimen Warrant Certificate.
	5*			Opinion of Morgan, Lewis & Bockius LLP.
	10	.1*		Amended and Restated License Agreement between Novogen Research Pty Limited and Marshall Edwards Pty Limited.
	10	.2*		Amended and Restated Manufacturing License and Supply Agreement between Novogen Laboratories Pty Limited and Marshall Edwards Pty Limited.
	10	.3*		Amended and Restated License Option Deed between Novogen Research Pty Limited and Marshall Edwards Pty Limited.
	10	.4*		Amended and Restated Services Agreement among Novogen Limited, Marshall Edwards, Inc. and Marshall Edwards Pty Limited.
	10	.5*		Guarantee and Indemnity among Marshall Edwards, Inc., Novogen Laboratories Pty Limited, Novogen Research Pty Limited and Novogen Limited.
	10	.6*		Marshall Edwards, Inc. Share Option Plan.
	10	.7*		Form of outstanding Warrant issued to Non-US Persons May 2002.
	10	.8*		Form of outstanding Warrant issued to US Persons May 2002.
	21	*		Subsidiaries of Marshall Edwards, Inc.
	23	.1*		Consent of Morgan, Lewis & Bockius LLP (contained in Exhibit 5).
	23	.2		Consent of Ernst & Young LLP.
	24	*		Power of Attorney (included on signature page).
	99	.1		Form of letter from Marshall Edwards, Inc. to eligible holders of its common stock and ordinary shares and American Depositary Receipts of Novogen Limited describing the Directed Share Subscription Program.
	99	.2*		Form of letter from Janney Montgomery Scott LLC to eligible holders.
	99	.3		Form of brokers letter.
	99	.4		Form of subscription agreement.

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* Previously filed.

[Form of Underwriting Agreement]                                     EXHIBIT 1.0



                                 2,000,000 UNITS

                             MARSHALL EDWARDS, INC.

                                COMMON STOCK AND

                        WARRANTS TO PURCHASE COMMON STOCK

                                 ---------------

                             UNDERWRITING AGREEMENT

                                 ---------------


                                                      Philadelphia, Pennsylvania
                                                      ________ __, 2003

Ladies and Gentlemen:

      Marshall Edwards, Inc., a Delaware corporation ("MEI"), proposes to sell
an aggregate of 2,000,000 units ("Units"), consisting of one share of its common
stock, par value $0.00000002 per share ("Common Stock"), and one warrant
("Warrant") to purchase an additional share of Common Stock, subject to the
terms and conditions stated herein. Of the 2,000,000 Units being offered, (i) up
to 1,500,000 (the "Directed Subscription Units"), are being sold by MEI as part
of a directed subscription program ("Directed Subscription Program"), to the
U.S. holders ("Eligible Holders") of Common Stock or of the Ordinary Shares or
American Depositary Receipts of Novogen Limited, an Australian registered
corporation, and the parent of MEI ("Novogen"), and (ii) 500,000 Units ("Firm
Units") are being sold by MEI to Janney Montgomery Scott LLC ("Underwriter"), as
part of a contemporaneous firm commitment underwritten public offering
("Underwritten Offering"). The Directed Subscription Units shall be offered and
sold to the Eligible Holders and the Firm Units shall be offered and sold to the
public at an offering price of $______ per Unit ("Offering Price"). The
Directed Subscription Program and the Underwritten Offering are not conditioned
upon one another.

      In addition, in the event that the Eligible Holders do not subscribe for
and purchase all of the Directed Subscription Units as part of the Directed
Subscription Program on or before the Closing Date (as defined below)(all such
Units not subscribed for and purchased by the Eligible Holders in the Directed


Subscription Program being referred to herein as "Unsubscribed Units"), MEI
shall issue and sell to the Underwriter, and the Underwriter shall purchase from
MEI the Unsubscribed Units to offer and sell as part of the Underwritten
Offering. The Unsubscribed Units shall be offered and sold to the public as part
of the Underwritten Offering at the Offering Price.


      MEI also proposes to grant to the Underwriter an option to purchase for
its own account additional Units representing up to 15% of the Firm Units and
Unsubscribed Units combined, which may be up to an additional 300,000 Units
("Optional Units"), from MEI to cover over-allotments in the sale of the Firm
Units and any Unsubscribed Units, subject to the terms and conditions stated
herein. If any Optional Units are so purchased, the Optional Units shall be
offered to the public by the Underwriter at the Offering Price and in accordance
with the terms and conditions set forth herein. The Directed Subscription Units,
Firm Units and the Optional Units are referred to collectively herein as the
"Units." The shares of Common Stock comprising part of the Units and those
underlying the Warrants are referred to collectively herein as the "Shares."

      Any preliminary prospectus included in such registration statement or
filed with the Securities and Exchange Commission (the "SEC"), pursuant to Rule
424(a) Securities Act of 1933, as amended (the "Act"), and the rules and
regulations (the "Regulations") of the SEC promulgated thereunder in effect at
all applicable times, is hereinafter called a "Preliminary Prospectus." The
various parts of such registration statement, including all exhibits thereto and
the information contained in the form of a final prospectus filed with the SEC
pursuant to Rule 424(b) of the Regulations in accordance with Section 7(a) of
this Agreement and deemed by virtue of Rule 424 of the Regulations to be part of
the registration statement at the time it was declared effective, each as
amended at the time the registration statement became effective, including the
information (if any) deemed to be part of the registration statement at the time
of effectiveness pursuant to Rule 430A of the Regulations, are hereinafter
collectively called the "Registration Statement." The final prospectus in the
form included in the Registration Statement or first filed with the SEC pursuant
to Rule 424(b) of the Regulations and any amendments or supplements thereto,
including the information (if any) deemed to be part of that prospectus at the
time of effectiveness pursuant to Rule 430A of the Regulations, is hereinafter
called the "Prospectus." If MEI has filed an abbreviated registration statement
to register additional Units pursuant to Rule 462(b) under the Act (the "Rule



                                      -2-

462 Registration Statement"), then any reference herein to the term
"Registration Statement" shall be deemed to include such Rule 462 Registration
Statement.

            MEI and the Underwriter, intending to be legally bound, hereby
confirm their agreement as follows:

            1. REPRESENTATIONS AND WARRANTIES OF MEI. MEI represents and
warrants to, and agrees with, the Underwriter that:


            (a) The Registration Statement has become effective under the Act,
      and the SEC has not issued any stop order suspending the effectiveness of
      the Registration Statement or preventing or suspending the use of the
      Preliminary Prospectus, nor has the SEC instituted or, to the knowledge of
      MEI, threatened to institute proceedings with respect to such an order. No
      stop order suspending the sale of the Units in any jurisdiction designated
      by the Underwriter as provided for in Section 5(f) hereof has been issued,
      and no proceedings for that purpose have been instituted or, to the
      knowledge of MEI, threatened. Each Preliminary Prospectus conformed to all
      the requirements of the Act and the Regulations as of its date in all
      material respects and did not as of its date contain any untrue statement
      of material fact or omit to state a material fact required to be stated
      therein or necessary to make the statements therein, in the light of the
      circumstances under which they were made, not misleading. The Registration
      Statement, on the date on which it was declared effective by the SEC (the
      "Effective Date") and when any post-effective amendment thereof shall
      become effective, and the Prospectus, at the time it is filed with the SEC
      including, if applicable, pursuant to Rule 424(b), and on the Closing Date
      (as defined in Section 4 hereof) and any Option Closing Date (as defined
      in Section 4(b) hereof), conformed and will conform in all material
      respects to all the requirements of the Act and the Regulations, and did
      not and will not, on any of such dates, contain any untrue statement of a
      material fact or omit to state a material fact required to be stated
      therein or necessary to make the statements therein in the case of the
      Prospectus, in the light of the circumstances under which they were made,
      not misleading. The two preceding sentences do not apply to statements in
      or omissions from the



                                      -3-

      Registration Statement or the Prospectus based upon written information
      furnished to MEI by or on behalf of the Underwriter expressly for use
      therein or the omission of any information regarding the Underwriter.

            (b) MEI is a corporation duly organized, validly existing and in
      good standing under the laws of the State of Delaware, and has the
      corporate power and authority to own or lease and operate its properties
      and to conduct its current business as described in the Prospectus, and to
      execute, deliver and perform this Agreement. MEI is duly qualified to do
      business, and is in good standing, in all jurisdictions in which such
      qualification is required, except where the failure to so qualify would
      not have a material adverse effect on the financial condition, results of
      operations, shareholders' equity or business (collectively, the "Business
      Conditions") of MEI.

            (c) There are no legal or governmental proceedings pending or, to
      the knowledge of MEI, threatened to which MEI is a party or to which any
      of the properties of MEI is subject which, if determined adversely to MEI
      would individually or in the aggregate have a material adverse effect on
      the Business Conditions of MEI.

            (d) This Agreement has been duly authorized, executed and delivered
      by MEI and constitutes its legal, valid and binding obligation,
      enforceable against MEI in accordance with its terms, except as
      enforcement may be limited by bankruptcy, insolvency or other similar laws
      affecting the enforcement of creditors' rights generally and subject to
      applicability of general principles of equity and except, as to this
      Agreement, as rights to indemnity and contribution may be limited by
      federal and state securities laws or principles of public policy.

            (e) The execution, delivery and performance of this Agreement and
      the transactions contemplated herein, do not and will not, with or without
      the giving of notice or the lapse of time, or both, (i) conflict with any
      term or provision of MEI's Restated Certificate of Incorporation; (ii)
      result in a breach of, constitute a default under, result in the
      termination or modification of, result in the creation or imposition of
      any lien, security interest, charge or encumbrance upon any of the
      properties of MEI or require any payment by MEI or impose any liability on
      MEI pursuant to, any contract, indenture, mortgage, deed of trust,
      commitment or other agreement or instrument to which MEI is a


                                      -4-

      party or by which any of its properties are bound or affected other than
      this Agreement, except where such breach, default, modification,
      termination, lien, security interest, charge, encumbrance, payment or
      liability could not reasonably be expected to have a material adverse
      effect on the Business Conditions of MEI, taken as a whole; (iii) assuming
      compliance with the rules of the National Association of Securities
      Dealers, Inc. (the "NASD") applicable to the offer and sale of the Units,
      violate any law, rule, regulation, judgment, order or decree of any
      government or governmental agency, instrumentality or court, domestic or
      foreign, having jurisdiction over MEI or any of its properties or
      businesses, except where such violation could not reasonably be expected
      to have a material adverse effect on the Business Conditions of MEI, taken
      as a whole; or (iv) result in a breach, termination or lapse of MEI's
      corporate power and authority to own or lease and operate its properties
      and conduct its business in any material respect, except as disclosed in
      the Prospectus.

            (f) At the date or dates indicated in the Prospectus, MEI had the
      duly authorized and outstanding capitalization set forth in the Prospectus
      under the caption "Capitalization" and will have, as of the issuance of
      the Units on the Closing Date, the as adjusted capitalization set forth
      therein as of the date indicated in the Prospectus assuming the Optional
      Units are not issued on the Closing Date. On the Effective Date, the
      Closing Date and any Option Closing Date, there will be no options or
      warrants or other outstanding rights to purchase, agreements or
      obligations to issue or agreements or other rights to convert or exchange
      any obligation or security into, capital stock of MEI, except as described
      in the Prospectus, or securities convertible into or exchangeable for
      capital stock of MEI, except as described in the Prospectus. The
      information in the Prospectus insofar as it relates to all outstanding
      options and other rights to acquire securities of MEI as of the dates
      referred to in the Prospectus is true and correct in all material
      respects.

            (g) The currently outstanding shares of Common Stock have been duly
      authorized and are validly issued, fully paid and non-assessable, and none
      of such outstanding shares has been issued in violation of any preemptive
      rights of any security holder of MEI. All previous offers and sales of the
      outstanding shares of Common Stock made by or on behalf of MEI, whether
      described in the Registration Statement or


                                      -5-

      otherwise, were made in conformity with applicable federal, state and
      foreign securities laws. The authorized capital stock of MEI, including,
      without limitation, the outstanding shares of Common Stock, the Units
      being issued, and any outstanding options to purchase Common Stock conform
      in all material respects with the descriptions thereof in the Prospectus,
      and such descriptions conform in all material respects with the
      instruments defining the same.

            (h) When the Units have been duly delivered against payment therefor
      as contemplated by this Agreement, the Common Stock delivered as part of
      the Units will be validly issued, fully paid and non-assessable, and the
      holders thereof will not be subject to personal liability solely by reason
      of being such holders. The certificates representing such shares of Common
      Stock are in proper legal form under, and on or before the first time of
      delivery conform in all material respects to the requirements of, the laws
      of the State of Delaware. Neither the filing of the Registration Statement
      nor the offering or sale of Units as contemplated by this Agreement gives
      any security holder of MEI any rights for or relating to the registration
      of any shares of Common Stock or any other capital stock of MEI or any
      rights to convert or have redeemed or otherwise receive anything of value
      with respect to any security of MEI.

             (i) No consent, approval, authorization, order, registration,
      license or permit of, or filing or registration with, any court,
      government, governmental agency, instrumentality or other regulatory body
      or official is required for the valid and legal execution, delivery and
      performance by MEI of this Agreement and the consummation of the
      transactions contemplated hereby or described in the Prospectus, except
      (i) such as may be required for the registration of the Units under the
      Act, the Exchange Act, and for compliance with the applicable state
      securities laws or the bylaws, rules and other pronouncements of the NASD
      or the Alternative Investment Market of the London Stock Exchange, and
      (ii) as disclosed in the Prospectus.

            (j) As of the Effective Date, the class of Common Stock (including
      the Shares) is registered pursuant to Section 12(g) of the Exchange Act
      and has been approved for inclusion and quotation on the Nasdaq SmallCap
      Market of The Nasdaq Stock Market, Inc. ("Nasdaq"). Neither MEI nor, to
      MEI's knowledge, any other person has taken any action designed to cause,
      or likely to result in, the termination of the registration of the Common
      Stock as a class under the


                                      -6-

      Exchange Act. MEI has not received any notification that the SEC nor
      Nasdaq is contemplating terminating such registration or inclusion.

            (k) No relationship, direct or indirect, exists between or among MEI
      on the one hand, and the directors, officers, stockholders, customers or
      suppliers of MEI on the other hand, which is required to be described in
      the Registration Statement or Prospectus which is not so described.

            (l) Each contract or other instrument (however characterized or
      described) to which MEI is a party or by which any of its properties or
      businesses is bound or affected and which is material to the conduct of
      MEI's business has been (i) duly and validly executed by MEI and, (ii) to
      the knowledge of MEI, by the other parties thereto. Each such contract or
      other instrument is in full force and effect and is enforceable in all
      material respects against the parties thereto in accordance with its
      terms, except as enforcement may be limited by bankruptcy, insolvency or
      other similar laws affecting the enforcement of creditors' rights
      generally and subject to applicability of general principles of equity,
      and MEI is not, and to MEI's knowledge, no other party thereto is, in
      default thereunder, except where such default would not have a material
      adverse effect on the Business Conditions of MEI, and no event has
      occurred that, with the lapse of time or the giving of notice, or both,
      would constitute a default under any such contract or other instrument.
      All necessary consents under such contracts or other instruments to the
      disclosure in the Prospectus with respect thereto have been obtained.

            (m) The consolidated financial statements of MEI (including the
      notes thereto) included in the Prospectus and the Registration Statement
      present fairly, in all material respects, the financial position of MEI as
      of the respective dates thereof, and the results of operations and cash
      flows of MEI for the periods indicated therein, all in conformity with
      generally accepted accounting principles, except as disclosed therein. The
      supporting notes included in the Registration Statement fairly state in
      all material respects the information required to be stated therein in
      relation to the financial statements taken as a whole. The financial
      information included in the Prospectus under the captions "Prospectus
      Summary - Summary Historical Consolidated Financial Data," "Selected
      Historical Consolidated Financial Data," "Use of Proceeds" and
      "Capitalization" presents fairly


                                      -7-

      the information shown therein and has been compiled on a basis consistent
      with that of the financial statements included in the Registration
      Statement.


            (n) Since the respective dates as of which information is given in
      the Registration Statement and the Prospectus, except as otherwise stated
      therein, there has not been (i) any material adverse change (including,
      whether or not insured against, any material loss or damage to any
      material assets), or to the knowledge of MEI, a development involving a
      prospective material adverse change, in the Business Conditions of MEI;
      (ii) any material adverse change, loss, reduction, termination or
      non-renewal of any material contract to which MEI is a party; (iii) any
      transaction entered into by MEI not in the ordinary course of its business
      that is material to MEI; (iv) any dividend or distribution of any kind
      declared, paid or made by MEI on its capital stock, except for and to the
      extent described in the Prospectus; (v) any liabilities or obligations,
      direct or indirect, incurred by MEI that are material to MEI other than
      the issuance of shares pursuant to the exercise of options or warrants
      outstanding as of the date hereof or the grant of options under MEI's
      stock option plans; (vi) any change in the capitalization of MEI; or (vii)
      any change in the indebtedness of MEI that is material to MEI. MEI has no
      contingent liabilities or obligations that are material to MEI that are
      required to be disclosed that are not so disclosed in the Registration
      Statement and Prospectus.


            (o) MEI has not distributed, and will not distribute, any offering
      material in connection with the offering and sale of the Units other than
      the Registration Statement, a Preliminary Prospectus, the Prospectus and
      other material, if any, permitted by the Act and the Regulations, subject
      to the prior consent of the Underwriter. Neither MEI nor any of its
      officers, directors or affiliates has (i) taken, nor shall MEI or such
      persons take, directly or indirectly, any action designed to, or that
      might be reasonably expected to, cause or result in stabilization or
      manipulation of the price of the Common Stock, or (ii) since the filing of
      the Registration Statement (A) sold, bid for, purchased or paid anyone any
      compensation for soliciting purchases of, the Common Stock or (B) paid or
      agreed to pay to any person any compensation for soliciting another to
      purchase any other securities of MEI.

            (p) MEI has filed with the appropriate federal, state and local
      governmental agencies, and all required


                                      -8-

      foreign countries and political subdivisions thereof, all material tax
      returns that are required to be filed or have duly obtained extensions of
      time for the filing thereof and have paid all taxes shown on such returns
      or otherwise due and all material assessments received by them to the
      extent that the same have become due, other than those being contested in
      good faith and for which adequate reserves have been provided. MEI has not
      executed or filed with any taxing authority, foreign or domestic, any
      agreement extending the period for assessment or collection of any income
      or other tax and none of them is a party to any pending action or
      proceeding by any foreign or domestic governmental agency for the
      assessment or collection of taxes, and no claims for assessment or
      collection of taxes have been asserted against MEI that might materially
      adversely affect the Business Conditions of MEI.

            (q) To the knowledge of MEI, Ernst & Young LLP ("E&Y"), which has
      given its report on certain financial statements included as part of the
      Registration Statement and Prospectus, is a firm of independent certified
      public accountants as required by the Act and the Regulations with respect
      to MEI.

            (r) MEI is not in violation of, or in default under, any of the
      terms or provisions of (i) its Restated Certificate of Incorporation and
      (ii) except where any such default would not reasonably be expected to
      have a material adverse effect on the Business Conditions of MEI, (A) any
      indenture, mortgage, deed of trust, contract, commitment or other
      agreement or instrument to which it is a party or by which it or any of
      its assets or properties is bound or affected, (B) any law, rule,
      regulation, judgment, order or decree of any government or governmental
      agency, instrumentality or court, domestic or foreign, having jurisdiction
      over it or any of its properties or business, or (C) any license, permit,
      certification, registration, approval, consent or franchise.

            (s) Except as expressly disclosed in the Registration Statement and
      Prospectus, there are no claims, actions, suits, protests, proceedings,
      arbitrations, investigations or inquiries pending before, or, to the
      knowledge of MEI, threatened or contemplated by, any governmental agency,
      instrumentality, court or tribunal, domestic or foreign, or before any
      private arbitration tribunal to which MEI is or may be made a party that
      could reasonably be expected to affect the validity of any of the


                                      -9-

      outstanding shares of Common Stock, or that, if determined adversely to
      MEI would, in any case or in the aggregate, result in any material adverse
      change in the Business Conditions of MEI. There are no outstanding orders,
      judgments or decrees of any court, governmental agency, instrumentality or
      other tribunal enjoining MEI from, or requiring MEI to take or refrain
      from taking, any action, or to which MEI or its properties, assets or
      businesses are bound or subject, except for such orders, judgments or
      decrees which would not have a material adverse effect on the Business
      Conditions of MEI.

            (t) MEI owns, or possesses adequate rights to use, all patents,
      patent applications, trademarks, trademark registrations, applications for
      trademark registration, trade names, service marks, licenses, inventions,
      copyrights, know-how (including any unpatented and/or unpatentable
      proprietary or confidential technology, information, systems, design
      methodologies and devices or procedures developed or derived from or for
      MEI's, business), trade secrets, confidential information, processes and
      formulations and other proprietary information necessary for, used in, or
      proposed to be used in, the conduct of the business of MEI as described in
      the Prospectus and the Registration Statement (collectively, the
      "Intellectual Property"), except where the failure to own or possess or
      otherwise be able to acquire such Intellectual Property would not have a
      material adverse effect on the Business Conditions of MEI. To the
      knowledge of MEI, it has not infringed, is not infringing nor have
      received any notice of conflict with, the asserted rights of others with
      respect to the Intellectual Property that, individually or in the
      aggregate, if the subject of an unfavorable decision, ruling or finding,
      could materially adversely affect the Business Conditions of MEI, and MEI
      knows of no reasonable basis therefor. To the actual knowledge of MEI, no
      other parties have infringed upon or are in conflict with any Intellectual
      Property. Except as described in the Prospectus and Registration
      Statement, MEI is not a party to, or bound by, any agreement pursuant to
      which royalties, honorariums or fees are payable by MEI to any person by
      reason of the ownership or use of any Intellectual Property.

            (u) The executive offices and facilities of MEI (the "Premises"),
      and all operations presently or formerly conducted thereon by MEI, are now
      and, since MEI began to use such Premises, always have been and, to the
      knowledge of MEI prior to when MEI began to use such Premises, always had


                                      -10-

      been, in compliance in all material respects with all statutes,
      ordinances, regulations, rules, standards and requirements of common law
      applicable to the areas in which MEI provides service concerning or
      relating to industrial hygiene and the protection of health and the
      environment (collectively, the "Environmental Laws"), except to the extent
      that any failure in such compliance would not materially adversely affect
      the Business Conditions of MEI. To the knowledge of MEI, there are no
      conditions on, about, beneath or arising from the Premises, in close
      proximity to the Premises or at any other location that might give rise to
      liability or the imposition of a statutory lien under any of the
      Environmental Laws and that would materially adversely affect the Business
      Conditions of MEI, except as described in the Prospectus and Registration
      Statement. Except as expressly disclosed in the Prospectus and
      Registration Statement, or which will not materially adversely affect the
      Business Conditions of MEI (i) MEI has not received written notice or has
      knowledge of any claim, demand, investigation, regulatory action, suit or
      other action instituted or threatened against MEI or any portion of the
      Premises or any parcel in close proximity to the Premises relating to any
      of the Environmental Laws and (ii) MEI has not received any written notice
      of material violation, citation, complaint, order, directive, request for
      information or response thereto, notice letter, demand letter or
      compliance schedule to or from any governmental or regulatory agency
      arising out of or in connection with "hazardous substances" (as defined by
      applicable Environmental Laws) on, about, beneath, arising from or
      generated at the Premises, near the Premises or at any other location.

            (v) MEI maintains a system of internal accounting controls
      sufficient to provide reasonable assurances that: (i) transactions are
      executed in accordance with management's general or specific
      authorization; (ii) transactions are recorded as necessary in order to
      permit preparation of financial statements in accordance with generally
      accepted accounting principles and to maintain accountability for assets;
      (iii) access to assets is permitted only in accordance with management's
      general or specific authorization; and (iv) the recorded accountability
      for assets is compared with existing assets at reasonable intervals and
      appropriate action is taken with respect to any differences.


                                      -11-

            (w) Other than as disclosed in the Prospectus, MEI has not
      established, maintained, contributed to, are required to contribute to,
      are a party to, or are bound by contractual commitments with respect to,
      pension, retirement, or profit-sharing plans, deferred compensation,
      bonus, or other incentive plans, or medical, vision, dental, or other
      health and welfare benefit plans, or life insurance or disability plans,
      or any other employee benefit plans, programs, arrangements, agreements,
      or understandings (the "Plans").

            (x) MEI has not incurred any liability for any finder's fees or
      similar payments in connection with the transactions contemplated herein
      other than as disclosed in the Prospectus and Registration Statement.

            (y) MEI is familiar with the Investment Company Act of 1940, as
      amended (the "1940 Act"), and the rules and regulations thereunder, and
      has in the past conducted, and MEI intends to conduct, its affairs in such
      a manner as to ensure that it will not be an "investment company" or an
      entity "controlled" by an investment company within the meaning of the
      1940 Act and the rules and regulations thereunder.

            (z) MEI has received all permits, licenses, franchises,
      authorizations, registrations, qualifications and approvals (collectively,
      "Permits") of governmental or regulatory authorities as may be required of
      it to own its properties and conduct its businesses in the manner
      described in the Prospectus and Registration Statement, subject to such
      qualifications as may be set forth therein, except to the extent that
      failure to receive such Permits would not have a material adverse effect
      on the Business Conditions of MEI; and MEI has fulfilled and performed all
      of its material obligations with respect to such Permits, and no event has
      occurred which allows or, after notice or lapse of time or both, would
      allow revocation or termination thereof or result in any other material
      impairment of the rights of the holder of any such Permit, subject in each
      case to such qualifications as may be set forth in the Prospectus and
      Registration Statement; and, except as described therein, such Permits
      contain no restrictions that materially affect the ability of MEI to
      conduct its business.

            (aa) No statement, representation, warranty or covenant made by MEI
      in this Agreement or in any certificate or document required by this
      Agreement to be delivered to the Underwriter is, or as of the Closing Date
      or any Option


                                      -12-

      Closing Date will be, inaccurate, untrue or incorrect in any material
      respect.

            (bb) Neither MEI nor to the knowledge of MEI any officer, director,
      employee, partner, agent or other person acting on behalf of MEI has,
      directly or indirectly, given or agreed to give any money, property or
      similar benefit or consideration to any customer or supplier (including
      any employee or agent of any customer or supplier) or official or employee
      of any agency or instrumentality of any government (foreign or domestic)
      or political party or candidate for office (foreign or domestic) or any
      other person who was, is or in the future may be in a position to affect
      the Business Conditions of MEI, or any actual or proposed business
      transaction of MEI that (i) could subject MEI to any liability (including,
      but not limited to, the payment of monetary damages) or penalty in any
      civil, criminal or governmental action or proceeding that would have a
      material adverse effect on the Business Conditions of MEI, or (ii) with
      respect to MEI or any officer or director thereof, violates any law, rule
      or regulation to which MEI is subject in any material respect.

            Any certificate signed by any officer of MEI in such capacity and
delivered to the Underwriter or to counsel for the Underwriter pursuant to this
Agreement shall be deemed a representation and warranty by MEI to the
Underwriter as to the matters covered thereby.


            2. PURCHASE AND SALE OF FIRM UNITS AND UNSUBSCRIBED UNITS. On the
basis of the representations, warranties, covenants and agreements contained
herein, but subject to the terms and conditions set forth herein, MEI shall sell
the Firm Units and all Unsubscribed Units, if any, to the Underwriter at the
Offering Price less the Underwriting Discounts and Commissions shown on the
cover page of the Prospectus, and the Underwriter shall purchase from MEI at the
Offering Price less the Underwriting Discounts and Commissions shown on the
cover page of the Prospectus, the Firm Units and any Unsubscribed Units. The
Underwriter shall offer the Firm Units and Unsubscribed Units to the public as
set forth in the Prospectus.


            3. PAYMENT AND DELIVERY.

            (a) The certificates representing the Common Stock and Warrants
      comprising the Firm Units and Unsubscribed Units, if any, sold in the
      Underwritten Offering shall be issued in such names as the Underwriter may
      request in


                                      -13-


      writing upon at least 24 hours' prior notice to MEI, and shall be
      delivered by or on behalf of MEI to the Underwriter against payment by the
      Underwriter on its behalf of the purchase price therefor by wire transfer
      of immediately available funds to such accounts as MEI shall designate in
      writing (with all costs and expenses incurred by the Underwriter in
      connection with such settlement in immediately available funds, including,
      but not limited to, interest or cost of funds and expenses, to be borne by
      MEI). The closing of the sale and purchase of the Firm Units and
      Unsubscribed Units, if any ("Underwritten Offering Closing"), shall be
      held at the offices of Pepper Hamilton LLP, 3000 Two Logan Square,
      Eighteenth & Arch Streets, Philadelphia, Pennsylvania 19103. Such payment
      and delivery will be made at 10:00 a.m., Philadelphia, Pennsylvania time,
      on the third business day after the date of this Agreement, or at such
      other time on the same or such other date, not later than seven business
      days thereafter as shall be designated in writing by the Underwriter. Such
      time and date are referred to herein as the "Closing Date." MEI shall make
      such certificates available for examination by the Underwriter and counsel
      for the Underwriter not less than one full business day prior to the
      Closing Date.



            (b) The certificates representing the Common Stock and Warrants
      comprising the Directed Subscription Units shall be issued in such names
      as the Underwriter, in its capacity as dealer manager for the Directed
      Subscription Program, may request in writing upon at least 24 hours' prior
      notice to MEI, and shall be delivered by or on behalf of MEI to the
      Underwriter against payment to MEI by the Underwriter, in its capacity as
      dealer manager, of the funds tendered or to be tendered in connection with
      subscriptions to purchase Directed Subscription Units ("Subscription
      Funds"), less a selling fee payable to the Underwriter, in its capacity as
      dealer manager, equal to three percent (3%) of the Subscription Funds, by
      wire transfer of immediately available funds to such accounts as MEI shall
      designate in writing (with all costs and expenses incurred by the
      Underwriter in connection with such settlement in immediately available
      funds, including, but not limited to, interest or cost of funds and
      expenses, to be borne by MEI). In the event that there are closings under
      the Directed Subscription Program and in the Underwritten Offering, such
      closings shall occur concurrently on the Closing Date. In the event the
      Underwritten Offering is terminated for any reason and the Directed
      Subscription Program is not terminated, the closing of the sale and
      purchase of the Directed Subscription Units shall occur on the Closing
      Date. MEI shall make such certificates available for examination by the
      Underwriter and counsel for



                                      -14-

      the Underwriter not less than one full business day prior to the Closing
      Date.

            4. OPTION TO PURCHASE OPTIONAL UNITS.

            (a) For the purposes of covering any over-allotments in connection
      with the distribution and sale of the Firm Units and Unsubscribed Units,
      if any, as contemplated by the Prospectus, subject to the terms and
      conditions herein set forth, the Underwriter is hereby granted an option
      by MEI to purchase all or any part of the Optional Units (the
      "Over-Allotment Option"). The purchase price to be paid for the Optional
      Units shall be the Offering Price less the Underwriting Discounts and
      Commissions shown on the cover page of the Prospectus. The Over-Allotment
      Option granted hereby may be exercised by the Underwriter as to all or any
      part of the Optional Units at any time and from time to time within 30
      days after the date of the Prospectus. The Underwriter shall not be under
      any obligation to purchase any Optional Units prior to an exercise of the
      Over-Allotment Option.

            (b) The Over-Allotment Option granted hereby may be exercised by the
      Underwriter by giving notice to MEI by a letter sent by telex, telegraph,
      telegram or facsimile (such notice to be effective when received),
      addressed as provided in Section 13 hereof, setting forth the number of
      Optional Units to be purchased, the date and time for delivery of and
      payment for the Optional Units and stating that the Optional Units
      referred to therein are to be used for the purpose of covering
      over-allotments in connection with the distribution and sale of the Firm
      Units and Unsubscribed Units, if any. If such notice is given at least two
      full business days prior to the Closing Date, the date set forth therein
      for such delivery and payment shall be not earlier than the Closing Date.
      If such notice is given after two full business days prior to the Closing
      Date, the date set forth therein for such delivery and payment shall be a
      date selected by the Underwriter not later than five full business days
      after the exercise of the Over-allotment Option. The date and time set
      forth in such a notice is referred to herein as an "Option Closing Date,"
      and a closing held pursuant to such a notice is referred to herein as an
      "Option Closing." Upon each exercise of the Over-Allotment Option, and on
      the basis of the representations, warranties, covenants and agreements
      herein contained, and subject to the terms and conditions herein set
      forth, the Underwriter shall become obligated to


                                      -15-

      purchase from MEI the number of Optional Units specified in each notice of
      exercise of the Over-Allotment option.

            (c) The certificates representing the Common Stock and Warrants
      comprising the Optional Units shall be issued in such names as the
      Underwriter may request in writing upon at least 48 hours' prior notice to
      MEI, and shall be delivered by or on behalf of MEI to the Underwriter
      against payment by the Underwriter on its behalf of the purchase price
      therefor by wire transfer of immediately available funds to such accounts
      as MEI shall designate in writing (with all costs and expenses incurred by
      the Underwriter in connection with such settlement in immediately
      available funds, including, but not limited to, interest or cost of funds
      and expenses, to be borne by MEI). The closing of the sale and purchase of
      the Optional Units shall be held at the offices of Pepper Hamilton LLP,
      3000 Two Logan Square, Philadelphia, Eighteenth & Arch Streets,
      Philadelphia, Pennsylvania 19103. Such payment and delivery will be made
      at 10:00 a.m., Philadelphia, Pennsylvania time, on the Option Closing
      Date. MEI shall make such certificates available for examination by the
      Underwriter and counsel for the Underwriter not less than one full
      business day prior to the Option Closing Date.

            5. CERTAIN COVENANTS AND AGREEMENTS OF MEI. MEI covenants and agrees
with the Underwriter as follows:

            (a) If Rule 430A of the Regulations is employed, MEI will timely
      file the Prospectus pursuant to and in compliance with Rule 424(b) of the
      Regulations and will advise the Underwriter of the time and manner of such
      filing.

            (b) MEI will not file with the SEC, the Prospectus, any amendment or
      supplement to the Prospectus or any amendment to the Registration
      Statement, unless the Underwriter has been advised or to which the
      Underwriter shall reasonably object after being so advised (unless MEI is
      advised by counsel that such amendment or supplement is required by law),
      and will use its best efforts to cause any such amendment to the
      Registration Statement to be declared effective as promptly as possible.
      Upon reasonable request of the Underwriter or counsel for the Underwriter,
      MEI will promptly prepare and file with the SEC, in accordance with the
      Regulations, any amendments to the Registration Statement or amendments or
      supplements to the Prospectus that may be necessary or advisable in
      connection with the distribution of the Units by the Underwriter and will
      use its best efforts to cause any such amendment to the Registration
      Statement to be


                                      -16-


      declared effective as promptly as possible. If required, MEI will file any
      amendment or supplement to the Prospectus with the SEC in the manner and
      within the time period required by Rule 424(b) under the Act. MEI will
      advise the Underwriter, promptly after receiving notice thereof, of the
      time when the Registration Statement or any amendment thereof has been
      filed or declared effective or the Prospectus or any amendment or
      supplement thereto has been filed and will provide evidence to the
      Underwriter of each filing or effectiveness.

            (c) MEI will advise the Underwriter immediately, and confirm such
      advice in writing, (i) when any post-effective amendment to the
      Registration Statement is filed with the SEC under Rule 462(c) under the
      Act or otherwise, (ii) any Rule 462(b) Registration Statement is filed,
      (iii) of the receipt of any comments from the SEC concerning the
      Registration Statement, (iv) when any post-effective amendment to the
      Registration Statement becomes effective, or when any supplement to the
      Prospectus or any amended Prospectus has been filed, (v) of any request of
      the SEC for amendment or supplementation of the Registration Statement or
      Prospectus or for additional information, (vi) during the period when the
      Prospectus is required to be delivered under the Act and Regulations, of
      the happening of any event as a result of which the Registration Statement
      or the Prospectus would include an untrue statement of a material fact or
      omit to state a material fact necessary to make the statements therein, in
      the light of the circumstances under which they were made, not misleading,
      (vii) during the period noted in clause (vi) above, of the need to amend
      the Registration Statement or supplement the Prospectus to comply with the
      Act, (viii) of the issuance by the SEC of any stop order suspending the
      effectiveness of the Registration Statement or of any order preventing or
      suspending the use of any Preliminary Prospectus or the Prospectus, and
      (ix) of the suspension of the qualification of any of the Units for
      offering or sale in any jurisdiction set forth on Schedule 5(f) in which
      the Underwriter intends to make such offers or sales, or the initiation or
      threatening of any proceedings for any of such purposes known to MEI. MEI
      will use its best efforts to prevent the issuance of any such stop order
      or of any order preventing or suspending such use, and if any such order
      is issued, to obtain as soon as possible the lifting thereof.

            (d) MEI will deliver to the Underwriter, without charge, from time
      to time during the period when delivery of


                                      -17-

      the Prospectus is required under the Act, such number of copies of the
      Prospectus (as supplemented or amended) as the Underwriter may reasonably
      request. MEI hereby consents to the use of such copies of the Preliminary
      Prospectus and the Prospectus for purposes permitted by the Act, the
      Regulations and the securities laws of the states in which the Units are
      offered by the Underwriter, both in connection with the offering and sale
      of the Units and for such period of time thereafter as the Prospectus is
      required by the Act to be delivered in connection with sales by the
      Underwriter. MEI has furnished or will furnish to the Underwriter at least
      one original signed copy of the Registration Statement as originally filed
      and of all amendments and supplements thereto, whether filed before or
      after the Effective Date, at least one copy of all exhibits filed
      therewith and of all consents and certificates of experts, and will
      deliver to the Underwriter such number of conformed copies of the
      Registration Statement, including financial statements and exhibits, and
      all amendments thereto, as the Underwriter may reasonably request.

            (e) MEI will comply with the Act, the Regulations, the Exchange Act
      and the Exchange Act Regulations so as to permit the continuance of sales
      of and dealings in the Units for as long as may be necessary to complete
      the distribution of the Units as contemplated hereby.

            (f) MEI will furnish such information and pay such filing fees and
      other expenses as may be required, including reasonable legal fees of
      Underwriter's counsel not to exceed $_______, and otherwise cooperate in
      the registration or qualification of the Units, or exemption therefrom,
      for offering and sale by the Underwriter under the securities laws of such
      state jurisdictions set forth on Schedule 5(f) in which the Underwriter
      determines to offer the Units ("Blue Sky"), and will file such consents to
      service of process or other documents necessary or appropriate in order to
      effect such registration or qualification; provided, however, that no such
      qualification shall be required in any jurisdiction where, solely as a
      result thereof, MEI would be subject to taxation or qualification as a
      foreign corporation doing business in such jurisdiction where it is not
      now so qualified or to take any action which would subject it to service
      of process in suits, other than those arising out of the offering or sale
      of the Units, in any jurisdiction where it is not now so subject. MEI
      will, from time to time, prepare and file such statements and reports as
      are or may be required to continue such qualification in effect for so
      long a period as is required under the Blue Sky laws of such jurisdictions
      for such offering and sale. MEI will furnish such information and pay such
      filing fees and other expenses as may be


                                      -18-

      required, and otherwise cooperate in the inclusion of the Common Stock,
      including the Shares, for quotation on the Nasdaq SmallCap Market. MEI
      will, from time to time, prepare and file such statements and reports as
      are or may be required to continue such qualification in effect for a
      period of three years from the Effective Date.


             (g) Subject to Section 5(b) hereof, in case of any event (occurring
      at any time within the period during which, in the opinion of counsel for
      the Underwriter, a prospectus is required to be delivered under the Act or
      the Regulations), as a result of which any Preliminary Prospectus or the
      Prospectus, as then amended or supplemented, would contain, in the opinion
      of counsel for the Underwriter, an untrue statement of a material fact, or
      omit to state any material fact necessary in order to make the statements
      therein, in the light of the circumstances under which they were made, not
      misleading, or, if it is necessary at any time to amend any Preliminary
      Prospectus or the Prospectus to comply with the Act or the Regulations or
      any applicable securities laws, MEI promptly will prepare and file with
      the SEC, and any applicable state securities commission, an amendment,
      supplement or document that will correct such statement or omission or
      effect such compliance and will furnish to the Underwriter such number of
      copies of such amendments, supplements or documents (in form and substance
      satisfactory to the Underwriter and counsel for the Underwriter) as the
      Underwriter may reasonably request. For purposes of this Section 5(g), MEI
      will provide such information to the Underwriter, the Underwriter's
      counsel and counsel to MEI as shall be necessary to enable such persons to
      consult with MEI with respect to the need to amend or supplement the
      Registration Statement, Preliminary Prospectus or Prospectus or file any
      document, and shall furnish to the Underwriter and the Underwriter's
      counsel such further information as each may from time to time reasonably
      request.


            (h) MEI will make generally available to its security holders not
      later than 45 days after the end of the fiscal quarter first occurring
      after the first anniversary of the Effective Date, an earnings statement
      of MEI (which need not be audited unless required by the Act or the
      Regulations) that shall comply with Section 11(a) of the Act and Rule 158



                                      -19-

      thereunder and cover a period of at least 12 consecutive months beginning
      not later than the first day of MEI's fiscal quarter next following the
      Effective Date (or, if later, the effective date of the Rule 462(b)
      Registration Statement).

            (i) For a period of three years from the Effective Date, MEI will
      deliver to the Underwriter upon request from the Underwriter (i) a copy of
      each report or document, including, without limitation, reports on Forms
      8-K, 10-K and 10-Q (or such similar forms as may be designated by the
      SEC), registration statements and any exhibits thereto, filed or furnished
      to the SEC or any securities exchange or Nasdaq, promptly after the date
      each such report or document is so filed or furnished; (ii) as soon as
      practicable, copies of any reports or communications (financial or other)
      of MEI mailed to its security holders; and (iii) every material press
      release in respect of MEI or its affairs that is released by MEI.

            (j) During the course of the distribution of the Units, MEI will not
      and MEI shall cause its officers and directors not to, (i) take, directly
      or indirectly, any action designed to, or that could reasonably be
      expected to, cause or result in stabilization or manipulation of the price
      of the Common Stock or (ii) sell, bid for, purchase or pay anyone any
      compensation for soliciting purchases of, the Units.

            (k) For a period of 120 days after the Effective Date, MEI will not,
      without the prior written consent of the Underwriter, issue or make a
      disposition of any Common Stock or any securities convertible into or
      exercisable or exchangeable for any Common Stock or enter into a
      transaction which would have the same effect or enter into any swap, hedge
      or other arrangement that transfers, in whole or in part, any of the
      economic consequences of ownership of Common Stock, whether any such
      aforementioned transaction is to be settled by delivery of Common Stock or
      such other securities, in cash or otherwise, or publicly disclose the
      intention to issue or make any such disposition or enter into any such
      transaction, swap, hedge or other arrangement, except ((i) the issuance of
      Common Stock upon the exercise of currently outstanding options and
      warrants as described in the Registration Statement and (ii) the grant of
      options to purchase Common Stock under MEI's currently outstanding stock
      option plans and the issuance of Common Stock upon the exercise thereof.


                                      -20-


                           (l) For a period of three years from the Effective
         Date, MEI will use all reasonable efforts to maintain the listing of
         the Common Stock (including the Shares) on the Nasdaq SmallCap Market
         or on a national securities exchange.

                           (m) MEI will use its best efforts to use the net
         proceeds from the sale of the Units to be sold by it hereunder
         substantially in accordance with the description set forth in the
         Prospectus.

                           6.       PAYMENT OF FEES AND EXPENSES.

                                    (a) Whether or not the transactions
         contemplated by this Agreement are consummated and regardless of the
         reason this Agreement is terminated, MEI will pay or cause to be paid,
         and bear or cause to be borne, all costs and expenses incident to the
         performance of the obligations of MEI under this Agreement, including:
         (i) the fees and expenses of the accountants and counsel for MEI
         incurred in the preparation of the Registration Statement and any
         post-effective amendments thereto (including financial statements and
         exhibits), Preliminary Prospectuses and the Prospectus and any
         amendments or supplements thereto; (ii) the fees and expenses of any
         information agent or solicitor engaged in connection with the Directed
         Subscription Program or otherwise, (iii) printing and mailing expenses
         associated with the Registration Statement and any post-effective
         amendments thereto, any Preliminary Prospectus, the Prospectus, this
         Agreement and related documents; (iv) the fees, expenses and other
         costs of, or incident to, securing any review or approvals by or from
         the NASD, including the reasonable fees and expenses of Underwriter's
         counsel in an amount not to exceed $ ________; (v) the filing fees of
         the SEC; (vi) the cost of furnishing to the Underwriter copies of the
         Registration Statement, Preliminary Prospectuses and Prospectuses as
         herein provided; (vii) MEI's travel expenses in connection with
         meetings with the brokerage community and institutional investors;
         (viii) the costs and expenses associated with settlement in same day
         funds (including, but not limited to, interest or cost of funds
         expenses), if desired by MEI; (ix) any fees or costs payable to Nasdaq
         as a result of the offering; (x) the cost of preparing, issuing and
         delivery to the Underwriter of any certificates evidencing the Shares
         and Warrants; (xi) the costs and charges of any transfer agent; (xii)
         the reasonable costs of advertising the offering if requested by MEI;
         (xiii) all taxes, if any, on the issuance, delivery and transfer of the
         Units sold by MEI; and (xiv) all other costs and expenses reasonably
         incident to the performance of MEI's obligations

                                      -21-

         hereunder that are not otherwise specifically provided for in this
         Section 6(a); provided, however, that the Underwriter shall be
         responsible for its out-of-pocket expenses, including those associated
         with meetings with the brokerage community and institutional investors,
         other than MEI's travel expenses, and the fees and expenses of its
         counsel for other than with respect to Blue Sky and NASD matters.

                           (b) MEI shall pay as due any state registration,
         qualification and filing fees and any accountable out-of-pocket
         disbursements in connection with such Blue Sky registration,
         qualification or filing in the states set forth on Schedule 5(f) in
         which the Underwriter determines to offer or sell the Units.


                           (c) If the sale of the Units is completed, in order
         to reimburse the Underwriter for costs and expenses associated with the
         offering, MEI will pay a non-accountable expense allowance of $150,000
         to the Underwriter on the Closing Date.


                  7. CONDITIONS OF UNDERWRITER' OBLIGATIONS. The obligation of
the Underwriter to purchase and pay for the Firm Units and Unsubscribed Units,
if any, that it has agreed to purchase hereunder on the Closing Date, and to
purchase and pay for any Optional Units as to which it exercises its right to
purchase under Section 4 on an Option Closing Date, is subject at the date
hereof, the Closing Date and any Option Closing Date to the continuing accuracy
and fulfillment of the representations and warranties of MEI, to the performance
by MEI of its covenants and obligations hereunder, and to the following
additional conditions:

                           (a) If required by the Regulations, the Prospectus
         shall have been filed with the SEC pursuant to Rule 424(b) of the
         Regulations within the applicable time period prescribed for such
         filing by the Regulations. On or prior to the Closing Date or any
         Option Closing Date, as the case may be, no stop order or other order
         preventing or suspending the effectiveness of the Registration
         Statement or the sale of any of the Units shall have been issued under
         the Act or any state securities law, and no proceedings for that
         purpose shall have been initiated or shall be pending or, to the
         Underwriter's knowledge or the knowledge of MEI, shall be contemplated
         by the SEC or by any authority in any jurisdiction designated by the
         Underwriter pursuant to Section 5(f) hereof. Any request on the part of
         the SEC or any state securities authority for additional information

                                      -22-

         shall have been complied with to the reasonable satisfaction of counsel
         for the Underwriter.

                           (b) All corporate proceedings and other matters
         incident to the authorization, form and validity of this Agreement, the
         Units, Shares and Warrants and the form of the Registration Statement
         and the Prospectus, and all other legal matters relating to this
         Agreement and the transactions contemplated hereby shall be
         satisfactory in all material respects to counsel for the Underwriter.
         MEI shall have furnished to such counsel all documents and information
         that they may have reasonably requested to enable them to pass upon
         such matters. The Underwriter shall have received from the
         Underwriter's counsel, Pepper Hamilton LLP an opinion, dated as of the
         Closing Date and any Option Closing Date, as the case may be, and
         addressed to the Underwriter, which opinion shall be satisfactory in
         all respects to the Underwriter.

                           (c) On the Closing Date and any Option Closing Date,
         there shall have been delivered to the Underwriter signed opinions of
         Morgan, Lewis & Bockius LLP, counsel for MEI, dated as of each such
         date and addressed to the Underwriter to the effect set forth in
         Exhibit A hereto or to such effect as is otherwise reasonably
         satisfactory to the Underwriter.

                           (d) At the Closing Date and any Option Closing Date:
         (i) the Registration Statement and any post-effective amendment thereto
         and the Prospectus and any amendments or supplements thereto shall
         comply as to form to the requirements of the Act and the Regulations in
         all material respects, and neither the Registration Statement nor any
         post-effective amendment thereto nor the Prospectus and any amendments
         or supplements thereto shall contain any untrue statement of a material
         fact or omit to state any material fact required to be stated therein
         or necessary to make the statements therein, and in the case of the
         Prospectus, in the light of the circumstances under which they were
         made, not misleading; (ii) since the respective dates as of which
         information is given in the Registration Statement and any
         post-effective amendment thereto and the Prospectus and any amendments
         or supplements thereto, except as otherwise stated therein, there shall
         have been no material adverse change in the Business Conditions of the
         MEI from that set forth therein, whether or not arising in the ordinary
         course of business; (iii) the respective dates as of which information
         is given in the Registration Statement and the Prospectus or

                                      -23-


         any amendment or supplement thereto, there shall have been no event or
         transaction, contract or agreement entered into by MEI other than in
         the ordinary course of business and as set forth in the Registration
         Statement or Prospectus, that has not been, but would be required to
         be, set forth in the Registration Statement or Prospectus; (iv) since
         the respective dates as of which information is given in the
         Registration Statement and any post-effective amendment thereto and the
         Prospectus and any amendments or supplements thereto, there shall have
         been no material adverse change, loss, reduction, termination or
         non-renewal of any contract to which MEI is a party, that has not been,
         but would be required to be set forth in the Registration Statement or
         Prospectus; and (v) no action, suit or proceeding at law or in equity
         shall be pending or to the knowledge of MEI threatened against MEI that
         would be required to be set forth in the Prospectus, other than as set
         forth therein, and no proceedings shall be pending or to the knowledge
         of MEI threatened against or directly affecting MEI before or by any
         federal, state or other commission, board or administrative agency
         wherein an unfavorable decision, ruling or finding would materially
         adversely affect the Business Conditions of MEI.



                           (e) The Underwriter shall have received at the
         Closing Date and any Option Closing Date certificates of the Chief
         Executive Officer and the Chief Financial Officer of MEI dated as of
         the date of the Closing Date or Option Closing Date, as the case may
         be, and addressed to the Underwriter to the effect that (i) the
         representations and warranties of MEI in this Agreement are true and
         correct in all material respects, as if made at and as of the Closing
         Date or the Option Closing Date, as the case may be, and that MEI has
         complied in all material respects with all the agreements, fulfilled
         all the covenants and satisfied all the conditions on its part to be
         performed, fulfilled or satisfied at or prior to the Closing Date or
         the Option Closing Date, as the case may be, and (ii) the signers of
         the certificate have carefully examined the Registration Statement and
         the Prospectus and any amendments or supplements thereto, and the
         conditions set forth in Section 7(e) hereof have been satisfied.


                           (f) At the time this Agreement is executed and at the
         Closing Date and any Option Closing Date the Underwriter shall have
         received a letter, dated the date of delivery thereof, addressed to the
         Underwriter, in form and substance satisfactory to the Underwriter in
         all respects (including, without limitation, the non-material nature of
         the changes or

                                      -24-

         decreases, if any, referred to in clause (iii) below) from E&Y:

                                    (i) confirming they are independent
                  certified public accountants within the meaning of the Act and
                  the Regulations;

                                    (ii) stating that, in their opinion, the
                  consolidated financial statements, schedules and notes of MEI
                  included in the Registration Statement comply as to form in
                  all material respects with the applicable accounting
                  requirements of the Act and the Regulations;

                                    (iii) stating that, on the basis of
                  specified procedures, which included the procedures specified
                  by the American Institute of Certified Public Accountants for
                  a review of interim financial information, as described in SAS
                  No. 71, Interim Financial Information (with respect to the
                  latest available unaudited consolidated financial statements
                  of the Company), a reading of the latest available unaudited
                  interim consolidated financial statements of MEI (with an
                  indication of the date of the latest available unaudited
                  interim financial statements), a reading of the minutes of the
                  meetings of the stockholders and the Board of Directors of MEI
                  and the Audit and Executive and Compensation Committees of
                  such Boards and inquiries to certain officers and other
                  employees of MEI responsible for operational, financial and
                  accounting matters and other specified procedures and
                  inquiries, nothing has come to their attention that would
                  cause them to believe that, at a specified date not more than
                  five business days prior to the date of such letter, there was
                  any: (A) change in the capital stock other than (1) the
                  issuance of Common Stock upon the exercise of currently
                  outstanding options and warrants as described in the
                  Prospectus, and (2) the grant of options to purchase Common
                  Stock under MEI's currently outstanding stock options plans
                  and the issuance of Common Stock upon the exercise thereof,
                  (B) increase in long-term debt of MEI, which is currently
                  $____________ or (C) any decrease in consolidated net current
                  assets or shareholders equity of MEI as compared with the
                  amounts shown in the June 30, 2003 audited balance sheets of
                  MEI included in the Registration Statement or that for the
                  periods from June 30, 2003 to the date of the latest available
                  unaudited financial statements of MEI, if any, and to a
                  specified date not

                                      -25-

                  more than five days prior to the date of the letter, there
                  were any decreases, as compared to the corresponding periods
                  in the prior year, in operating income or total or per share
                  amounts of net income, except in all instances for changes,
                  decreases or increases that the Registration Statement
                  discloses have occurred or may occur and except for such other
                  changes, decreases or increases which the Underwriter shall in
                  their sole discretion accept;

                                    (iv) stating that they have compared
                  specific dollar amounts (or percentages derived from such
                  dollar amounts), numbers of shares and other numerical data
                  and financial information set forth in the Registration
                  Statement that have been reasonably specified by the
                  Underwriter prior to the date of this Agreement (in each case
                  to the extent that such dollar amounts, percentages and other
                  information is derived from the general accounting records
                  subject to the internal controls of MEI's accounting systems,
                  or has been derived directly from such accounting records by
                  analysis or comparison or has been derived from other records
                  and analyses maintained or prepared by MEI) with the results
                  obtained from the application of readings, inquiries and other
                  appropriate procedures set forth in the letter, and found them
                  to be in agreement. and

                                    (v) stating that, on the basis of specified
                  procedures, which included (A) a review of the unaudited
                  consolidated balance sheet as of September 30, 2003 and the
                  unaudited consolidated statement of income for the quarter
                  ended September 30, 2003, included in the Registration
                  Statement; (B) inquiry of management who have responsibility
                  for financial and accounting matters, that nothing came to
                  their attention as a result of the above procedures, that
                  caused them to believe that the unaudited consolidated
                  financial statements included in the Registration Statement do
                  not comply as to form in all material respects with the
                  applicable accounting requirements of Regulation S-X.

                           (g) The Common Stock, including the Shares, shall
         have been included for quotation on the Nasdaq SmallCap Market.

                           (h) The NASD has confirmed that it has not raised any
         objection with respect to the fairness and reasonableness of the
         underwriting terms and arrangements.


                                      -26-

                           (i) At the Closing Date and any Option Closing Date,
         the Underwriter shall have been furnished such additional documents,
         information and certificates as they shall have reasonably requested.

                  All such opinions, certificates, letters and documents shall
be in compliance with the provisions hereof only if they are reasonably
satisfactory in form and substance to the Underwriter and the Underwriter's
counsel. MEI shall furnish the Underwriter with such conformed copies of such
opinions, certificates, letters and other documents as they shall reasonably
request. If any condition to the Underwriter's obligations hereunder to be
fulfilled prior to or at the Closing Date or any Option Closing Date, as the
case may be, is not fulfilled, the Underwriter may terminate this Agreement with
respect to the Closing Date or such Option Closing Date, as applicable, or, if
they so elect, in its sole discretion waive any such conditions which have not
been fulfilled or extend the time for their fulfillment. Any such termination
shall be without liability of the Underwriter to MEI.

                  8.       INDEMNIFICATION AND CONTRIBUTION.

                           (a) MEI shall indemnify and hold harmless the
         Underwriter, and each person, if any, who controls the Underwriter
         within the meaning of the Act, against any and all loss, liability,
         claim, damage and expense whatsoever, including, but not limited to,
         any and all reasonable expenses incurred in investigating, preparing or
         defending against any litigation, commenced or threatened, or any claim
         whatsoever or in connection with any investigation or inquiry of, or
         action or proceeding that may be brought against, the respective
         indemnified parties, arising out of or based upon any untrue statements
         or alleged untrue statements of material fact contained in any
         Preliminary Prospectus, the Registration Statement or the Prospectus,
         any application or other document filed in any jurisdiction in order to
         qualify all or any part of the Units under the securities laws thereof
         or filed with the SEC or The Nasdaq Stock Market, Inc. (in this Section
         8 collectively called "application"), or in any materials or
         information provided to investors by, or with the approval of, MEI in
         connection with the marketing of the offering (including any materials
         provided to Eligible Holders in the Directed Subscription Program), or
         the omission or alleged omission from any of the foregoing of a
         material fact required to be stated therein or necessary to make the
         statements therein and in the case of the Prospectus, in the light of
         the circumstances under which

                                      -27-


         they were made, not misleading; provided, however, that the foregoing
         indemnity shall not apply in respect of any statement or omission made
         in reliance upon and in conformity with written information furnished
         to MEI by the Underwriter expressly for use in any Preliminary
         Prospectus, the Registration Statement or Prospectus, or any amendment
         or supplement thereto, or in any application or in any communication to
         the SEC, as the case may be (which information consists solely of the
         information identified in Section 11 herein); and further provided,
         however, that the indemnification contained in this Section 8(a) with
         respect to any Preliminary Prospectus shall not inure to the benefit of
         the Underwriter (or to the benefit of any person controlling the
         Underwriter) on account of any such loss, claim, liability or expense
         arising from the sale of the Units by the Underwriter to any person if
         a copy of the Prospectus shall not have been delivered or sent to such
         person within the time required by the Act and the regulations
         thereunder, and the untrue statement or alleged untrue statement or
         omission or alleged omission of a material fact contained in such
         Preliminary Prospectus was corrected in the Prospectus, provided that
         MEI has delivered the Prospectus to the Underwriter in requisite
         quantity on a timely basis to permit such delivery or sending. The
         obligations of MEI under this Section 8(a) will be in addition to any
         liability MEI may otherwise have.


                           (b) The Underwriter shall indemnify and hold harmless
         MEI, each of the directors of MEI, each of the officers of MEI who
         shall have signed the Registration Statement and each other person, if
         any, who controls MEI within the meaning of the Act to the same extent
         as the foregoing indemnities from MEI to the Underwriter, but only with
         respect to any and all loss, liability, claim, damage or expense
         resulting from statements or omissions, or alleged statements or
         omissions, if any, made in any Preliminary Prospectus, Registration
         Statement or Prospectus or any amendment or supplement thereof or any
         application or in any communication to the SEC in reliance upon, and in
         conformity with written information furnished to MEI by the Underwriter
         expressly for use in any Preliminary Prospectus, the Registration
         Statement or Prospectus or any amendment or supplement thereof or any
         application or in any communication to the SEC, as the case may be. The
         obligations of the Underwriter under this Section 8(b) will be in
         addition to any liability which the Underwriter may otherwise have.


                                      -28-

                           (c) If any action, inquiry, investigation or
         proceeding is brought against any person in respect of which
         indemnification may be sought pursuant to Section 8(a) or (b) hereof,
         such person (hereinafter called the "indemnified party") shall,
         promptly after notification of, or receipt of service of process or,
         such action, inquiry, investigation or proceeding, notify in writing
         the party or parties against whom indemnification is to be sought
         (hereinafter called the "indemnifying party") of the institution of
         such action, inquiry, investigation or proceeding. The indemnifying
         party, upon the request of the indemnified party, shall assume the
         defense of such action, inquiry, investigation or proceeding,
         including, without limitation, the employment of counsel (reasonably
         satisfactory to such indemnified party) and payment of expenses. No
         indemnification provided for in Section 8 shall be available to any
         indemnified party who shall fail to give such notice if the
         indemnifying party does not have knowledge of such action, inquiry,
         investigation or proceeding to the extent that such indemnifying party
         has been materially prejudiced by the failure to give such notice, but
         the omission to so notify the indemnifying party shall not relieve the
         indemnifying party otherwise than under Section 8. Such indemnified
         party shall have the right to employ its or their own counsel in any
         such case, but the fees and expenses of such counsel shall be at the
         expense of such indemnified party unless the employment of such counsel
         shall have been authorized in writing by the indemnifying party in
         connection with the defense of such action or if the indemnifying party
         shall not have employed counsel reasonably satisfactory to the
         indemnified party or if such indemnified party or parties shall have
         been advised by counsel that there may be a conflict between the
         positions of the indemnifying party or parties and of the indemnified
         party or parties or that there may be legal defenses available to such
         indemnified party or parties different from or in addition to those
         available to the indemnifying party or parties, in any of which events
         the indemnified party or parties shall be entitled to select counsel to
         conduct the defense to the extent determined by such counsel to be
         necessary to protect the interests of the indemnified party or parties,
         and the reasonable fees and expenses of such counsel shall be borne by
         the indemnifying party. The indemnifying party shall be responsible for
         the fees and disbursements of only one such counsel so engaged by the
         indemnified party or parties. Expenses covered by the indemnification
         in Section 8, as the case may be, shall be paid by the indemnifying
         party as they are incurred by the indemnified party. No indemnifying
         party

                                      -29-

         shall, without the prior written consent of the indemnified party,
         effect any settlement of any pending or threatened action in respect of
         which any indemnified party is or could have been a party and indemnity
         could have been sought hereunder by such indemnified party unless such
         settlement includes an unconditional release of such indemnified party
         from all liability on any claims that are the subject matter of such
         action. Notwithstanding anything in Section 6 or Section 7 to the
         contrary, an indemnifying party shall not be liable for any settlement
         of a claim effected without its written consent, which consent shall
         not be unreasonably withheld.

                           (d) If the indemnification provided for in this
         Section 8 is unavailable or insufficient to hold harmless an
         indemnified party under Section 8(a) or (b) hereof in respect of any
         losses, liabilities, claims, damages or expenses (or actions,
         inquiries, investigations or proceedings in respect thereof) referred
         to therein, except by reason of the failure to give notice as required
         in Section 8(c) hereof (provided that the indemnifying party does not
         have knowledge of the action, inquiry, investigation or proceeding and
         to the extent such party has been materially prejudiced by the failure
         to give such notice), then each indemnifying party shall contribute to
         the amount paid or payable by such indemnified party as a result of
         such losses, liabilities, claims, damages or expenses (or actions,
         inquiries, investigations or proceedings in respect thereof, in such
         proportion as is appropriate to reflect the relative benefits received
         by MEI on the one hand and the Underwriter on the other from the
         offering of the Units. If, however, the allocation provided by the
         immediately preceding sentence is not permitted by applicable law, then
         each indemnifying party shall contribute to such amount paid or payable
         by such indemnified party in such proportion as is appropriate to
         reflect not only such relative benefits but also the relative fault of
         MEI on the one hand and the Underwriter on the other in connection with
         the statements or omissions which resulted in such losses, liabilities,
         claims or expenses (or actions, inquiries, investigations or
         proceedings in respect thereof), as well as any other relevant
         equitable considerations. The relative benefits received by MEI on the
         one hand and the Underwriter on the other shall be deemed to be in the
         same proportion as the total net proceeds from the offering (before
         deducting expenses) received by MEI bears to the total underwriting
         discount and commissions received by the Underwriter, in each case as
         set forth in the table on the

                                      -30-

         cover page of the Prospectus. The relative fault shall be determined by
         reference to, among other things, whether the untrue or alleged untrue
         statement of a material fact or the omission or alleged omission to
         state a material fact relates to information supplied by MEI on the one
         hand or the Underwriter on the other hand and the parties' relative
         intent, knowledge, access to information and opportunity to correct or
         prevent such statement or omission.

                  MEI and the Underwriter agree that it would not be just and
equitable if contributions to this Section 8(d) were determined by pro rata
allocation or by any other method of allocation that does not take account of
the equitable considerations referred to above in this Section 8(d). The amount
paid or payable by an indemnified party as a result of the losses, liabilities,
claims, damages or expenses (or actions, inquiries, investigations or
proceedings in respect thereof) referred to above in this Section 8(d) shall be
deemed to include any legal or other expenses reasonably incurred by such
indemnified party in connection with investigating or defending any such action
or claim. Notwithstanding the provisions of this Section 8(d) no person guilty
of fraudulent misrepresentation (within the meaning of Section 11(f) of the Act)
shall be entitled to contribution from any person who was not guilty of such
fraudulent misrepresentation.

                  9. REPRESENTATIONS AND AGREEMENTS TO SURVIVE DELIVERY. Except
as the context otherwise requires, all representations, warranties and
agreements contained in this Agreement shall be deemed to be representations,
warranties and agreements at the Closing Date and any Option Closing Date. All
such representations, warranties and agreements of the Underwriter and MEI,
including, without limitation, the indemnity and contribution agreements
contained in Section 8 hereof and the agreements contained in Sections 5, 6, 10
and 11 hereof, shall remain operative and in full force and effect regardless of
any investigation made by or on behalf of the Underwriter or any controlling
person, and shall survive delivery of the Units and termination of this
Agreement, whether before or after the Closing Date or any Option Closing Date.

                  10. EFFECTIVE DATE OF THIS AGREEMENT AND TERMINATION HEREOF.

                           (a) This Agreement shall become effective upon the
         execution hereof by the parties hereto.


                                      -31-


                           (b) The Underwriter shall have the right to terminate
         this Agreement at any time prior to the Closing Date or any Option
         Closing Date as provided in Section 7 hereof or if any of the
         following have occurred: (i) any outbreak of hostilities or other
         national or international calamity or crisis or change in economic,
         political or financial market conditions if the effect on the financial
         markets of the United States of such outbreak, calamity, crisis (other
         than those that presently exist) or change would, in the Underwriter's
         reasonable opinion, make the offering or delivery of the Units
         impracticable; (ii) any suspension or limitation of trading generally
         in securities on the Nasdaq SmallCap Market or any setting of minimum
         prices for trading or the promulgation of any federal or state statute,
         regulation, rule or order of any court or other governmental authority
         that in the Underwriter's reasonable opinion materially and adversely
         affects trading on such exchange or the over-the-counter market; (iii)
         the enactment, publication, decree or other promulgation of any federal
         or state statute, regulation, rule or order of any court or other
         governmental authority which in the Underwriter's reasonable opinion
         materially and adversely affects or will materially or adversely affect
         the business or operations of MEI; (iv) declaration of a banking
         moratorium by the United States, New York or Pennsylvania authorities;
         or (v) trading in any securities of MEI shall have been suspended or
         halted on the Alternative Investment Market of the London Stock
         Exchange.


                           (c) If the Underwriter elects to terminate this
         Agreement as provided in this Section 10, the Underwriter shall notify
         MEI hereof promptly by telephone, telex, telegraph, telegram or
         facsimile, confirmed by letter.


                           (d) If the Underwriter elects to terminate this
Agreement as provided in this Section 10, MEI shall have the right, but not the
obligation, to terminate the Directed Subscription Program. If MEI elects to
terminate the Directed Subscription Program as provided in this Section 10, MEI
shall take reasonable measures to notify the Eligible Holders and promptly
return all Subscription Funds without interest or deduction.




                  11. INFORMATION FURNISHED BY UNDERWRITER. The statement set
forth on the [third] paragraph from the bottom of the cover page of the
Prospectus regarding the terms of the Offering by the Underwriter, the
information set forth under the heading "Underwritten Public Offering" and the
last two paragraphs under the section "Plan of Distribution" constitute the only
written information furnished by reference or on behalf of the Underwriter.



                                      -32-

                  12. NOTICE. All communications hereunder, except as herein
otherwise specifically provided, shall be in writing and shall be mailed,
delivered, telexed, telegrammed, telegraphed or telecopied and confirmed to
Janney Montgomery Scott LLC, 1801 Market Street, Philadelphia, Pennsylvania
19103, Attention: Mr. William L. Rulon-Miller, facsimile number (215) 665-6197
with a copy to Pepper Hamilton LLP, 3000 Two Logan Square, Eighteenth & Arch
Streets, Philadelphia, Pennsylvania 19103, Attention: Barry M. Abelson, Esq.;
facsimile 215-981-4750; if sent to MEI, shall be mailed, delivered, telexed,
telegrammed, telegraphed or telecopied and confirmed to Marshall Edwards, Inc.,
140 Wicks Road, North Ryde NSW 2113, Australia, Attention: David R. Seaton,
Secretary, facsimile number 011-61-2-8877-6273, with a copy to Morgan Lewis &
Bockius LLP, 101 Park Avenue, New York, NY 10178, Attention: Steven A. Navarro,
Esq., facsimile number 212-309-6273.

                  14. PARTIES. This Agreement shall inure solely to the benefit
of, and shall be binding upon, the Underwriter, MEI and the controlling persons,
directors and officers thereof, and their respective successors, assigns, heirs
and legal representative, and no other person shall have or be construed to have
any legal or equitable right, remedy or claim under or in respect of or by
virtue of this Agreement or any provision herein contained. The terms
"successors" and "assigns" shall not include any purchaser of the Units merely
because of such purchase.

                  15. DEFINITION OF BUSINESS DAY. For purposes of this
Agreement, "business day" means any day on which the Nasdaq SmallCap Market is
opened for trading.

                  16. COUNTERPARTS. This Agreement may be executed in one or
more counterparts and all such counterparts will constitute one and the same
instrument.

                  17. CONSTRUCTION. This Agreement shall be governed by and
construed in accordance with the laws of the Commonwealth of Pennsylvania
applicable to agreements made and performed entirely within such Commonwealth.




                                      -33-

                  If the foregoing correctly sets forth your understanding of
our agreement, please sign and return to MEI the enclosed duplicate hereof,
whereupon it will become a binding agreement in accordance with its terms.

                                        Very truly yours,

                                        MARSHALL EDWARDS, INC.



                                        By:  _______________________________

                                             Name:
                                             Title:




The foregoing Agreement is hereby confirmed
and accepted as of the date first above written.

JANNEY MONTGOMERY SCOTT LLC

By:  _______________________________
     Name:
     Title:




                                      -34-

                                    EXHIBIT A

             Matters to be Covered in the Opinion of Counsel for MEI

                  1. MEI has been duly organized and is validly existing as a
corporation in good standing under the laws of Delaware with corporate power and
authority to own its properties and conduct its business as described in the
Prospectus.


                  2. MEI has authorized and outstanding capital stock as set
forth under the caption "Capitalization" in the Prospectus. The outstanding
shares of Common Stock have been duly authorized and validly issued, to such
counsel's knowledge, and are fully paid and non-assessable. The Common Stock
conforms as to legal matters in all material respects to the description thereof
contained in the Prospectus. Certificates for the Shares are in due and proper
form and the Shares have been duly authorized and will be validly issued, fully
paid and non-assessable when issued and paid for as contemplated by this
Agreement; and no preemptive rights of stockholders, by operation of law, or to
the knowledge of such counsel, by contract exists with respect to any of the
Shares or the issue and sale thereof.


                  3. Based on the oral advice of a staff member of the SEC, the
Registration Statement has become effective under the Act, and no stop order
proceedings with respect thereto have been instituted or are pending or, to the
best knowledge of such counsel, threatened under the Act.

                  4. The Registration Statement, the Prospectus and each
amendment or supplement thereto when filed with the SEC comply as to form in all
material respects with the requirements of the Act, as applicable, and the
applicable rules and regulations thereunder (except that such counsel need
express no opinion as to the financial statements and notes thereto, schedules
and other financial, accounting and statistical information included therein).

                  5. The statements under the caption "Description of Capital
Stock" and "Shares Eligible for Future Sale" in the Prospectus, insofar as such
statements constitute a summary of documents referred to therein or matters of
law, are accurate and fairly present in all material respects the information
called for with respect to such documents and matters.


                                      -35-

                  6. Such counsel does not know of any contracts or documents
required to be filed as exhibits to the Registration Statement or described in
the Registration Statement or the Prospectus that are not so filed or described
as required, and such required contracts and documents as are summarized in the
Registration Statement or the Prospectus are fairly summarized in all material
respects.

                  7. To such counsel's knowledge, there are no material legal
proceedings pending or threatened against MEI, except as set forth in the
Prospectus.

                  8. This Agreement has been duly authorized, executed and
delivered by MEI, and, assuming due authorization and execution by the
Underwriter, constitutes the valid and binding agreement of MEI, enforceable
against MEI, in accordance with its terms, subject, as to enforcement, to
applicable bankruptcy, insolvency, reorganization and moratorium laws and other
laws relating to or affecting the enforcement of creditors' rights generally and
to general equitable principles (regardless of whether such enforceability is
considered a proceeding in equity or law) and except as the enforceability of
rights to indemnity and contribution under this Agreement may be limited under
applicable securities laws or the public policy underlying such laws. The
execution and delivery of this Agreement and the consummation of the
transactions herein contemplated does not and will not conflict with or result
in a breach of any of the terms or provisions of, or constitute a default under,
the Restated Certificate of Incorporation or Amended and Restated Bylaws of MEI,
or to such counsel's knowledge, any agreement or instrument to which MEI is a
party or by which it may be bound that is filed as an exhibit to the
Registration Statement.

                  9. No approval, consent, order or authorization by any
regulatory, administrative or other governmental body is necessary in connection
with the execution and delivery of this Agreement and the consummation of the
transactions herein contemplated (other than as may be required by the NASD or
by state securities and Blue Sky laws as to which such counsel need express no
opinion) other than such as have been obtained, including without limitation,
registration of the Units, Shares and Warrants under the Act and of the Common
Stock under the Exchange Act.

                  10. Neither MEI nor any of its subsidiaries is an "investment
company" or an entity "controlled" by an "investment company" within the meaning
of the Investment Company Act of 1940, as amended, and the rules and regulations
thereunder.


                                      -36-


                  11. Such counsel shall state that: although such counsel is
not passing upon and does not assume any responsibility for the accuracy,
completeness or fairness of the statements contained in the Registration
Statement or the Prospectus, except as and to the extent set forth in paragraph
5 of such counsel's opinion, on the basis of the foregoing and the information
disclosed to such counsel, but without independent check and verification, and
relying as to materiality to a large extent on representations and statements of
officers and other representatives of MEI, such counsel has participated in
conferences with officers and other representatives of MEI, representatives of
the Underwriter and its counsel, and representatives of the independent public
accountants of MEI, at which conferences the contents of the Registration
Statement and the Prospectus were discussed, and no facts have come to the
attention of those lawyers in such counsel's firm who have participated in the
preparation of the Registration Statement and the Prospectus that would cause
such counsel to have reason to believe that, insofar as relevant to the offering
of the Units, (a) the Registration Statement or any post-effective amendment
thereto as of the time it became effective, contained any untrue statement of a
material fact or omitted to state any material fact necessary to make the
statements therein not misleading, or that (b) the Prospectus on the Effective
Date, on the date it was filed pursuant to Rule 424(b) and on the Closing Date
or Option Closing Date, as the case may be, contained or contains any untrue
statement of material fact or omits to state any material fact necessary to make
the statements therein, in the light of the circumstances under which they were
made, not misleading; except that with respect to both clause (a) and (b) above
such counsel need make no statement with respect to the financial statements and
notes thereto, financial schedules and financial, accounting and statistical
information included in the Registration Statement or the Prospectus or with
respect to the validity, enforceability or non-infringement of any patent or
license of a patent.



                  The foregoing opinion may be limited to the laws of the
Commonwealth of Pennsylvania, the General Corporation Law of the State of
Delaware and the federal securities laws of the United States and include such
other limitations and assumptions as are customary. Such counsel may rely as to
questions of fact upon the representations of MEI set forth in this Agreement
and upon certificates of officers of MEI and of government officials, all of
which certificates must be satisfactory in form and scope to counsel for the
Underwriter.



                                      -37-

                                                                    Exhibit 23.2

                        Consent of Independent Auditors

We consent to the reference to our firm under the captions "Summary Historical
Consolidated Financial Data" and "Experts" and to the use of our report dated
July 31, 2003, in Amendment No. 2 to Registration Statement (Form S-1 No.
333-109129) and related Prospectus of Marshall Edwards, Inc. (a development
stage company) for the registration of 2,300,000 common stock units.

                                             /s/ Ernst & Young LLP

Stamford, Connecticut
November 25, 2003

                                                                    EXHIBIT 99.1


                             MARSHALL EDWARDS, INC.



                               NOVEMBER 26, 2003


To:  Certain Eligible Security Holders
     Designated by Marshall Edwards, Inc.:

     As you may know, Marshall Edwards, Inc. is undertaking an initial public
offering of common stock units in the United States. Each unit consists of one
share of our common stock and one warrant to purchase an additional share of
common stock. As part of this process, we are undertaking a "Directed Share
Subscription Program" to offer certain security holders such as you with the
opportunity to buy our common stock units at the initial public offering price.
The initial public offering is being made through Janney Montgomery Scott LLC as
the underwriter. Janney Montgomery Scott is also the dealer manager for the
Directed Share Subscription Program.


     Attached for your information is a copy of our preliminary prospectus dated
November 26, 2003, which is part of the registration statement that we filed
with the U.S. Securities and Exchange Commission ("SEC"). No sale of the common
stock units may be made until the registration statement has been declared
effective by the SEC.



     As part of the Directed Share Subscription Program, we are offering up to
1,500,000 common stock units to the following persons: (i) U.S. holders of our
common stock, (ii) U.S. holders of ordinary shares of Novogen Limited, our
parent company, and (iii) U.S. holders of Novogen's American Depositary Receipts
("ADRs"), in each case, who beneficially owned these securities as of the close
of business on October 20, 2003. Set forth below is a description of how the
Directed Share Subscription Program will work in connection with our initial
public offering. Please review this description and the attached preliminary
prospectus carefully in deciding whether or not you wish to participate in the
Directed Share Subscription Program.



EXPRESSIONS OF INTEREST



     If, after reading the prospectus, you have an interest in subscribing to
purchase common stock units in the Directed Share Subscription Program, you must
so indicate by completing the enclosed Expression of Interest form and returning
it as instructed below. You may not reserve fewer than 100 units (a "round
lot"). There is no maximum on the number of units you can reserve, but they must
be in round lot increments. Although each subscriber will be allocated at least
one round lot, no subscriber will be assured of obtaining the full number of
units requested. It should also be understood that such reservations of units
and ultimate sales are subject to the discretion of Marshall Edwards, Inc.



     THE EXPRESSION OF INTEREST FORM MUST BE COMPLETED AND RECEIVED BY US NO
LATER THAN DECEMBER 12, 2003. IN ORDER TO MEET THIS DEADLINE, WE SUGGEST THAT
YOU SUBMIT THE FORM BY FACSIMILE OR USE EXPRESS MAIL, FEDERAL EXPRESS, OR A
SIMILAR SERVICE.



     By sending the Expression of Interest form (do not send any money with the
form), you will not be binding yourself to purchase any units. The form will
simply give us some indication of how many round lots may be requested by you
and other eligible security holders. You will be notified by an account
executive for the dealer manager of the number of round lots which Marshall
Edwards, Inc. has determined are available for purchase by you.




                            SUBSCRIPTION PROCEDURES



WHO CAN SUBSCRIBE



     Only U.S. holders of our common stock, U.S. holders of Novogen ordinary
shares and U.S. holders of Novogen ADRs, who beneficially owned these securities
as of the close of business on October 20, 2003, are eligible to participate in
the Directed Share Subscription Program.


YOU MAY NOT TRANSFER YOUR OPPORTUNITY TO SUBSCRIBE

     Your opportunity to participate in the Directed Share Subscription Program
may not be transferred by you except by involuntary operation of law such as
death or certain dissolutions. There will be no trading market for your
subscription opportunity.

NUMBER OF UNITS FOR WHICH YOU MAY SUBSCRIBE


     There is no maximum on the number of round lots for which you can
subscribe. While all eligible holders who subscribe for units will receive at
least one round lot, you are not guaranteed to receive the full amount of units
for which you have subscribed. In addition, all subscriptions must be in round
lot increments of 100 units. Subscriptions for less than 100 units will not be
accepted.


SUBSCRIPTION PRICE


     The price per common stock unit under the Directed Share Subscription
Program will be the same price that all investors will pay in our initial public
offering. The price per unit in the initial public offering will be determined
by negotiations between us and the underwriter of our offering. The factors that
we expect to consider in these negotiations are described in the attached
prospectus under the heading "Determination of Offering Price." We currently
anticipate that the offering price will be between $4.50 and $6.50 per unit
although there is no guarantee that the price will be within that range. We will
inform you of the initial public offering price as described below under "How To
Subscribe."


HOW TO SUBSCRIBE


     Enclosed with this notice is a subscription form, new client account form
and IRS Form W-9 which you must complete, sign and return to the dealer manager
after the registration statement has been declared effective by the SEC and we
have priced the common stock units. We expect to determine the initial public
offering price in mid December 2003, but various factors could hasten or delay
us. We will stop accepting subscription forms three business days after we
determine the initial public offering price.


     IN ORDER TO PURCHASE UNITS UNDER THE DIRECTED SHARE SUBSCRIPTION PROGRAM,
YOU MUST ADHERE TO THE FOLLOWING PROCEDURES:

     - Subscription forms and payments will not be accepted until after we have
       determined our initial public offering price and the registration
       statement has been declared effective by the SEC. Any subscription forms
       or payments received before then will be returned to you.

     - Time may not permit us to notify you directly of our initial public
       offering price and closing date. Instead, we will take the following
       actions:

      - notify you by electronic mail of the offering price and closing date (if
        you have supplied us with your electronic mail address);

      - publicize the offering price and the closing date through a press
        release or other news media;

      - make every effort to notify each broker, dealer, bank, trust company or
        other nominee that holds shares or ADRs as nominee of the offering price
        and closing date; and


      - make available an investor information line at 877-456-3510.


                                        2



     You will have to monitor these media to know when to place your order by
returning an executed subscription form, new client account form and IRS Form
W-9 and deliver payment.


     We will stop accepting orders under the program at 3:00 p.m. New York City
time on the third business day after we determine the offering price.
Subscription forms and payments that have not been received by this deadline
will not be honored. For example, if we determine the initial public offering
price on a Thursday, we must receive all orders and payments by 3:00 p.m. New
York City time on the following Tuesday. This deadline would be extended if
there were any intervening holidays on which the Nasdaq Stock Market was closed.


     We suggest, for your protection, that you deliver the required forms and
payment to the dealer manager by overnight or express mail courier (or by
facsimile transmission if you intend to wire funds) as follows:


By Hand Delivery, Overnight or Express Mail
   Courier:

     Janney Montgomery Scott LLC
     16 North Washington Street, 1st Floor
     Easton, MD 21601
     Attention: Richard Grieves, Manager
     Fax: 410-822-6025
     Tel: 410-822-1181
     E-mail: rgrieves@jmsonline.com
By Facsimile Transmission and Wire Transfer:

     Fax: 410-822-6025
     Attention: Richard Grieves, Manager
     Wire: Commerce Bank, Philadelphia, PA
     Fax: 215-587-9501
     Tel: 800-677-6310
     ABA #036001808
     A/C Janney Montgomery Scott LLC
     Acct #364003889


     The full subscription price must be paid by cash, check or money order in
U.S. dollars payable to "Janney Montgomery Scott" or by wire transmission. If
you do not receive all of the units for which you subscribed, your excess
subscription funds will be promptly returned without interest or deduction.


     We will provide to each broker, dealer, bank, trust company, clearing
corporation and other nominee who holds your shares or ADRs for the account of
others copies of the preliminary and final prospectus to provide to the
beneficial owners. Each of those entities will be responsible for providing you
with a copy of the preliminary and final prospectus.


     We will decide all questions as to the validity, form and eligibility of
subscriptions (including times of receipt, beneficial ownership and compliance
with minimum and other subscription provisions). The acceptance of subscription
forms, the subscription price and the subscription amount will be determined by
us. Alternative, conditional or contingent subscriptions will not be accepted.
We reserve the absolute right to reject any subscriptions not properly
submitted. In addition, we may reject any subscription if the acceptance of the
subscription would be unlawful. We also may waive any irregularities or
conditions in the subscription forms, and our interpretation of the terms and
conditions of the program will be final and binding.



     We are not obligated to give you notification of defects in your
subscription. We will not consider a subscription to be made until all defects
have been cured or waived. If your subscription is rejected, your funds will be
promptly returned without interest or deduction.


CANCELLATION OF OFFERING


     We may cancel our Directed Share Subscription Program at any time up until
the closing. In the event the initial public offering of our common stock units
is canceled, however, we are not obligated to terminate the Directed Share
Subscription Program. If the Directed Share Subscription Program is canceled, we
will publicize the cancellation through a press release or other news media.
Since our initial public offering and the Directed Share Subscription Program
are not conditioned upon each other, if you subscribe for units in the Directed
Share Subscription Program, you may be obligated to purchase the units even if
you are the only subscriber or even if our initial public offering is canceled.
The Directed Share Subscription Program gives you no right to purchase our
common stock units if we cancel our Directed Share Subscription Program. Any
funds previously submitted by you will be promptly returned without interest or
deduction.

                                        3


FEDERAL TAX CONSEQUENCES

     We believe that you will not be considered to have received a taxable
distribution of property as a result of your having the opportunity to
participate in this offering. Furthermore, we believe that, if the opportunity
were considered to be a property right, its value would be minimal, because your
opportunity is nontransferable, is of short duration and gives you only the
ability to purchase our units under the program at the same price as other
purchasers in our initial public offering. The Internal Revenue Service,
however, is not bound by this position, and you are encouraged to consult with
your tax advisors about the federal, state and other tax consequences of the
program.

STABILIZATION

     The underwriter of our initial public offering may engage in certain
transactions that stabilize the price of our common stock and warrants. We make
no representation as to the direction or magnitude of any effect that such
transactions may have on the trading price of our common stock or warrants.

RISK FACTORS


     Investing in our common stock units involves certain risks which are
disclosed on page 6 of the attached preliminary prospectus. You are encouraged
to review this information.



GENERAL



     The following statement is required to be included in this letter by the
rules and regulations of the SEC:


          A Registration Statement relating to the common stock units has been
     filed with the Securities and Exchange Commission but has not yet become
     effective. These securities may not be sold nor may offers to buy be
     accepted prior to the time the Registration Statement becomes effective.
     This notice shall not constitute an offer to sell or the solicitation of
     any offer to buy nor shall there be any sale of these securities in any
     sate in which such offer, solicitation or sale would be unlawful prior to
     registration or qualification under the securities laws of any such sate.


                                     * * *


     We do not wish to influence in any way your decision in this matter. This
notice is not designed to encourage you to request any units. It is simply
intended to inform you that there is a proposed offering available should you be
interested in subscribing.


     If you have any questions regarding the Directed Share Subscription
Program, please contact Innisfree M&A Incorporated, the Information Agent, toll
free at 877-456-3510 (banks and brokers call collect at 212-750-5833).


                                          Sincerely,

                                          /s/ CHRISTOPHER NAUGHTON

                                          Christopher Naughton

                                          President and Chief Executive Officer



                                        4



                          EXPRESSION OF INTEREST FORM



IF YOU ARE INTERESTED IN RESERVING UNITS, YOU MUST COMPLETE BOTH PAGES OF THIS
FORM AND RETURN IT SO THAT IT IS RECEIVED BY US AS INDICATED BELOW NO LATER THAN
DECEMBER 12, 2003.



VIA FACSIMILE 410-822-6025


Janney Montgomery Scott LLC
16 North Washington Street
Easton, MD 21601
Attention: Mr. Richard Grieves


Dear Ladies and Gentlemen:



     I am interested in purchasing _________________ common stock units of
Marshall Edwards, Inc. (the "Company"), and would like such number of units to
be reserved for me. In this regard, I hereby acknowledge that:



          1.  I have received and read my copy of the preliminary prospectus
     dated November 26, 2003.



          2.  I UNDERSTAND THAT I AM NOT ASSURED OF OBTAINING ALL OF THE NUMBER
     OF UNITS RESERVED, AND I WILL BE NOTIFIED OF THE NUMBER OF UNITS AVAILABLE
     FOR PURCHASE BY ME. I FURTHER UNDERSTAND THAT THE OFFERING AND/OR DIRECTED
     SUBSCRIPTION PROGRAM MAY BE CANCELLED BY THE COMPANY IN ITS DISCRETION AND
     THAT THEY ARE NOT CONDITIONED UPON EACH OTHER.



          3.  A Registration statement relating to the units has been filed with
     the SEC and has not yet become effective. No offer to buy any of the units
     can be accepted and no part of the purchase price can be received by the
     Company or dealer manager until the Registration Statement covering the
     proposed offering has been declared effective by the Securities and
     Exchange Commission and until the units have been qualified for sale, where
     required, by the administrative authorities of the jurisdiction in which I
     reside, and any such offer may be withdrawn or revoked, without obligation
     or commitment of any kind, at any time prior to notice of its acceptance
     given after the effective date of the Registration Statement. This
     indication of interest involves no obligation or commitment of any kind.



                                      SIGNATURE



                                      NAME:



                                      DATE:           , 2003




IF YOU ARE INTERESTED IN RESERVING UNITS, YOU MUST COMPLETE BOTH PAGES OF THIS
FORM AND RETURN IT SO THAT IT IS RECEIVED BY US AS INDICATED BELOW NO LATER THAN
DECEMBER 12, 2003.


Full Name ----------------------------------------          Date ---------------
                  FIRST            MIDDLE INITIAL            LAST

Street -------------------------------------------------------------------------

City -------------------------        State ---------------       Zip ----------




Telephone:    Business (   ) ---------------     Residence (   ) ---------------


E-mail address: ----------------------------------------------------------------


Citizen of What State? ---------------------------------------------------------


Are You Over 21? ---------------------------------------------------------------

May we notify you of the final subscription price by e-mail?  Yes [ ]     No [ ]


Do you have an account with Janney Montgomery Scott LLC, the dealer manager? ---



If so, Address Of Branch

- --------------------------------------------------------------------------------


Name of Account Executive -----------------------------------------------------


Account No. --------------------------------------------------------------------


Name of Your Bank --------------------------------------------------------------



I  [ ] Do     [ ] Do Not (Check One) Want the Dealer Manager To Hold The Stock
Certificate and Warrant Certificate For My Account.



     Are you, or is any member of your immediate family, an officer, director,
general partner, stockholder, employee or agent of any broker-dealer in
securities or otherwise associated with any broker-dealer in securities? If so,
please name the broker-dealer and describe the relationship.


                          Yes -----          No -----

     Are you, or is any member of your immediate family, a senior officer of a
bank, savings and loan institution, insurance company, registered investment
company, registered investment advisory firm or any other institutional type
account? If so, please name the bank, etc. and describe the relationship.

                          Yes -----          No -----

     Are you, or any member of your immediate family, engaged as an attorney,
accountant or financial consultant to any broker-dealer in securities? If so,
please name the broker-dealer and describe the relationship.
                          Yes -----          No -----

     Are you, or is any member of your immediate family, a person who may
influence, or whose activities directly or indirectly involve or are related to,
the function of buying or selling securities, for any bank, savings and loan
institution, insurance company, registered investment company, registered
investment advisory firm or any other institutional type account? If so, please
name the bank, etc. and describe the relationship.
                          Yes -----          No -----



                                        2

                                                                    EXHIBIT 99.3


                             MARSHALL EDWARDS, INC.



                               NOVEMBER 26, 2003

Dear Broker:


     We are undertaking an initial public offering of common stock units and
conducting a Directed Share Subscription Program as part of the offering. Under
this program, each U.S. holder of our common stock, each U.S. holder of ordinary
shares of our parent, Novogen Limited, and each U.S. holder of Novogen ADRs, in
each case, who beneficially owned these securities as of the close of business
on October 20, 2003, will be eligible to subscribe for a minimum of one round
lot. There is no maximum number of units that any one eligible holder may
subscribe for under the Directed Share Subscription Program, but the units must
be purchased in round lot increments. While eligible holders are not guaranteed
to receive the full amount of units that they subscribed for, each will receive
at least one round lot. The price per unit under this program will be the same
price that all investors will pay in our initial public offering.


     The opportunity to participate in this program may not be transferred.
There will be no trading market for this subscription opportunity.


     IN ORDER FOR YOUR CUSTOMERS TO PURCHASE UNITS UNDER THE PROGRAM, YOU WILL
HAVE TO ACT PROMPTLY AND FORWARD THE FOLLOWING MATERIALS: (I) LETTER TO ELIGIBLE
SECURITY HOLDERS FROM MARSHALL EDWARDS, INC.; (II) EXPRESSION OF INTEREST FORM;
(III) SUBSCRIPTION FORM; (IV) NEW CLIENT ACCOUNT FORM; AND (V) IRS FORM W-9.



     Subscription forms and payments cannot be accepted until after we have
determined our initial public offering price. Once the initial public offering
price has been determined, we will take the actions outlined in the accompanying
letter to publicize the subscription price and the date by which eligible
holders must respond to the offer. The Depository Trust Company has advised us
that they will notify their participants electronically of the initial public
offering price and the expiration date for this program. Innisfree M&A
Incorporated, the Information Agent, will provide you with final prospectuses
for distribution to the eligible holders who received a preliminary prospectus.
Banks and brokers who require additional copies of any documents may call
Innisfree collect at 212-750-5833.



     All subscription forms and payments must be received by Janney Montgomery
Scott LLC, our dealer manager for the Directed Share Subscription Program and
underwriter of our initial public offering, by 3:00 p.m. New York City time on
the third business day after we have determined the initial public offering
price.


     A Registration Statement relating to the common stock units has been filed
with the Securities and Exchange Commission but has not yet become effective.
These securities may not be sold nor may offers to buy be accepted prior to the
time the Registration Statement becomes effective. This notice shall not
constitute an offer to sell or the solicitation of any offer to buy nor shall
there be any sale of these securities in any state in which such offer,
solicitation or sale would be unlawful prior to registration or qualification
under the securities laws of any such state.


     If you have any questions regarding the Directed Share Subscription
Program, please call Innisfree M&A Incorporated, the Information Agent, collect
at 212-750-5833 (beneficial owners may call toll free at 877-456-3510). Please
do not call Marshall Edwards directly.


                                          Sincerely,

                                          /s/ CHRISTOPHER NAUGHTON

                                          Christopher Naughton


                                          President and Chief Executive Officer

                                                                    EXHIBIT 99.4



                             MARSHALL EDWARDS, INC.

                      DIRECTED SHARE SUBSCRIPTION PROGRAM


                               SUBSCRIPTION FORM


     The securityholder named below is subscribing to purchase, pursuant to the
terms and conditions of the Marshall Edwards, Inc. Directed Share Subscription
Program, the number of common stock units, each unit consisting of one share of
common stock, par value $.00000002 per share, and one warrant to purchase one
share of common stock, of Marshall Edwards, Inc. indicated on the reverse at a
subscription price that will be determined as outlined below. THE DIRECTED SHARE
SUBSCRIPTION PROGRAM WILL EXPIRE AT 3:00 P.M. NEW YORK CITY TIME ON THE THIRD
BUSINESS DAY AFTER THE INITIAL PUBLIC OFFERING PRICE IS DETERMINED. As described
in the preliminary prospectus accompanying this subscription form, each U.S.
holder of our common stock, each U.S. holder of Novogen ordinary shares and each
U.S. holder of Novogen American Depository Receipts ("ADRs"), in each case who
beneficially owned these securities as of the close of business on October 20,
2003, will be eligible to purchase a minimum of 100 units, or one round lot.
There is no maximum on the number of units that any one eligible holder may
subscribe for under the Directed Share Subscription Program, but the units must
be purchased in round lot increments. Eligible holders are not guaranteed to
receive the full amount of units that they subscribed for, but each will receive
at least one round lot.


     The subscription price per unit under the program will be the same price
that all investors will pay in Marshall Edward Inc.'s initial public offering.
The price per unit will be determined by negotiations between Marshall Edwards,
Inc. and the underwriter of the offering. The factors to be considered in these
negotiations are described in the preliminary prospectus accompanying this
subscription form under the heading "Determination of Offering Price." Marshall
Edwards, Inc. currently anticipates that its initial public offering price will
be determined in mid December 2003, but various factors could hasten or delay
this determination. Time will not permit Marshall Edwards, Inc. to notify you
directly of the subscription price and the expiration date for the program, but
it will take the actions described in the accompanying letter to publicize this
information.


     The Directed Share Subscription Program and the initial public offering of
common stock units are not conditioned upon each other. Marshall Edwards Inc.
may decide in its discretion to cancel the Directed Share Subscription Program.
If you subscribe for units in the Directed Share Subscription Program, you may
be obligated to purchase units even if you are the only subscriber or if the
initial public offering is canceled. The Directed Share Subscription Program
gives you no right to purchase common stock units if it is cancelled and any
subscription funds previously submitted will be promptly returned without
interest or deduction.


     No offer to buy securities can be accepted, and no part of the subscription
price can be received, until the initial public offering price has been
determined and the registration statement, of which the preliminary prospectus
accompanying this subscription form is a part, has been declared effective by
the SEC. Any subscription forms or payments received before then will be
returned to you. All persons electing to subscribe to purchase units must
complete the Election to Purchase on the reverse side of this form and the
accompanying new client account form and IRS Form W-9 and return them, together
with full payment of the subscription price, to the dealer manager at the
address set forth below. If you do not properly complete and sign these required
forms, your subscription may be rejected. The required forms and full payment of
the subscription price must be received by the dealer manager no later than 3:00
p.m. New York City time on the third business day after the initial public
offering price is determined. We will not honor any subscriptions received after
that time and date. Before completing and returning this subscription form,
however, you are urged to read carefully the preliminary prospectus mailed to
you with this subscription form for a more complete explanation of the offering
and for information about Marshall Edwards, Inc.




     You should not return the subscription materials or deliver any payment
until after we have determined the initial public offering price and the
registration statement has been declared effective by the SEC. Any subscription
materials or payment received before then will be returned to you. Once the
initial public offering price has been determined, we will take the actions
described in the accompanying letter to publicize the subscription price and the
date by which you must respond to the offer that has been made to you under this
program.


     We suggest, for your protection, that you deliver the completed
subscription form, new client account form and IRS Form W-9 and payment of the
subscription price to the dealer manager by overnight or express mail courier.
The address for the dealer manager is as follows:


     By Hand Delivery, Overnight Delivery or
     by Express Mail Courier:
          Janney Montgomery Scott LLC
          16 North Washington Street, 1st Floor
          Easton, MD 21601
          Attention: Richard Grieves, Manager

By Facsimile Transmission and Wire Transfer:



     Fax: 410-822-6025
     Attention: Richard Grieves, Manager
     Wire: Commerce Bank, Philadelphia, PA
     Fax: 215-587-9501
     Tel: 800-677-6310
     ABA #036001808
     A/C Janney Montgomery Scott LLC
     Acct #364003889


                            ------------------------


                              ELECTION TO PURCHASE


     Subject to the terms and conditions of the Directed Share Subscription
Program described in the preliminary prospectus, receipt of which is hereby
acknowledged, the undersigned hereby elects to purchase common stock units of
Marshall Edwards, Inc., Inc. as indicated below.


Number of units purchased(1) -------- (NOTE: 100 unit minimum;


                                          round lot increments only)(2)



Per Unit Subscription Price $ --------  Payment enclosed(3) $ --------



     Certificates representing common stock and warrants of Marshall Edwards,
Inc. will be issued promptly following the closing of the offering. Such units
will be registered in the same manner as set forth below. When signing as
attorney, executor, administrator, trustee or guardian, please give your full
title as such. If signing for a corporation, an authorized officer must sign and
provide title. If signing for a partnership, an authorized partner must sign and
indicate title. Please provide a telephone number at which you can be reached in
the event that we have questions regarding the information that you have
supplied.


Daytime Telephone Number  (   )
- ----------------------------------------------

Evening Telephone Number  (   )
- ----------------------------------------------

e-mail address:
- ----------------------------------------------------------------------



                                        SIGNATURE(S):  --------------------

                                        Dated:  --------------------, 2003


                                        Name:  --------------------


                                        Title:  --------------------

- ---------------

(1) If the amount enclosed is not sufficient to pay the subscription price for
    all units that are stated to be purchased, or if the number of units being
    purchased is not specified, the number of units purchased will be assumed to
    be the maximum round lot number that could be purchased upon payment of such
    amount. Any amount remaining after such division shall be promptly returned
    to the subscriber.



(2) Any order for less than the minimum purchase requirement will be rejected.



(3) The subscription price must be paid by cash, check, wire transfer or money
    order in U.S. dollars representing "good funds" payable to Janney Montgomery
    Scott. The payment amount should equal the total units purchased multiplied
    by the per unit subscription price.


                                        5


                              SUBSTITUTE FORM W-9


              DEPARTMENT OF THE TREASURY, INTERNAL REVENUE SERVICE


               PAYER'S REQUEST FOR TAXPAYER IDENTIFICATION NUMBER


              FAILURE TO COMPLETE THIS FORM MAY SUBJECT YOU TO 31%
                        FEDERAL INCOME TAX WITHHOLDING.


Part 1:  Please provide your taxpayer identification number (TIN) in the space
provided at right and certify by signing and dating below


TIN
- ---------------------------------------------------------
          Social Security or Employer
            Identification Number

Part 2:  Check the box if you are awaiting a TIN [       ]

Part 3:  Certification -- under penalties of perjury, I certify that (1) the
number shown on this form is my correct taxpayer identification number (or a TIN
has not issued to me but I have mailed or delivered an application to receive a
TIN or intend to do so in the near future), (2) I am not subject to backup
withholding either because I have not been notified by the Internal Revenue
Service (the "IRS") that I am subject to backup withholding as a result of a
failure to report all interest or dividends or the IRS has notified me that I am
no longer subject to backup withholding, and (3) all other information provided
on this form is true, correct and complete.

Dated: --------------------, 2003                Signature: --------------------

You must cross out item (2) above if you have been notified by the IRS that you
are currently subject to backup withholding because of underreporting interest
or dividends on your tax return. However, if after being notified by the IRS
that you were subject to backup withholding, you received another notification
from the IRS that you are no longer subject to backup withholding, do not cross
out item (2).

                                        6